4.7 Article

Trends in the Association of Parental History of Obesity over 60 Years

Journal

OBESITY
Volume 22, Issue 3, Pages 919-924

Publisher

WILEY
DOI: 10.1002/oby.20564

Keywords

-

Funding

  1. National Heart, Lung and Blood Institute's Framingham Heart Study [N01-HC-25195, 2K24 HL04334]

Ask authors/readers for more resources

Objective: The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain. Methods: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. Results: BMI was 1.49 kg/m(2) higher per each affected parent among the Offspring, and increased to 2.09 kg/m(2) higher among the Third Generation participants (P-value for the cohort comparison = 0.007). Parental history of obesity was associated with increased weight gain (P< 0.0001) and incident obesity (P = 0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (P = 0.11 for test of trend across the time periods). Conclusions: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Endocrinology & Metabolism

Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

Pomme I. H. G. Simons, Olivier Valkenburg, Marjo P. H. van de Waarenburg, Marleen M. J. van Greevenbroek, M. Eline Kooi, Jacobus F. A. Jansen, Casper G. Schalkwijk, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers

Summary: Serum SHBG mediates the association between IHL content and type 2 diabetes, with a higher contribution in women.

DIABETOLOGIA (2023)

Article Nutrition & Dietetics

Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Elena C. Tore, Amany K. Elshorbagy, Frans C. H. Bakers, Martijn C. G. J. Brouwers, Pieter C. Dagnelie, Simone J. P. M. Eussen, Jacobus F. A. Jansen, M. Eline Kooi, Yvo H. A. M. Kusters, Steven J. R. Meex, Thomas Olsen, Helga Refsum, Kjetil Retterstol, Casper G. Schalkwijk, Coen D. A. Stehouwer, Kathrine J. Vinknes, Marleen M. J. van Greevenbroek

Summary: This study examined the association between plasma sulfur amino acids and different fat depots. The results showed that methionine was associated with liver fat, while total cysteine was associated with overall obesity and central fat deposition.

EUROPEAN JOURNAL OF NUTRITION (2023)

Article Psychology, Clinical

The association of white matter connectivity with prevalence, incidence and course of depressive symptoms: The Maastricht Study

Anouk F. J. Geraets, Sebastian Kohler, Laura W. M. Vergoossen, Walter H. Backes, Coen D. A. Stehouwer, Frans Rj Verhey, Jacobus Fa Jansen, Thomas T. van Sloten, Miranda T. Schram

Summary: This study investigated the association between markers of white matter connectivity and depressive symptoms. The findings suggest that fewer white matter connections may contribute to prevalent depressive symptoms and its persistence.

PSYCHOLOGICAL MEDICINE (2023)

Article Hematology

Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications

Matthew Nayor, Priya Gajjar, Venkatesh L. Murthy, Patricia E. Miller, Raghava S. Velagaleti, Martin G. Larson, Ramachandran S. Vasan, Gregory D. Lewis, Gary F. Mitchell, Ravi V. Shah

Summary: By measuring the changes in blood pressure and vascular stiffness, the cardiac and vascular components of exercise blood pressure can be analyzed. The study found that higher peak exercise blood pressure is associated with both higher arterial stiffness and higher cardiac-peripheral performance, especially in women. Therefore, studying the response of blood pressure to exercise in relation to vascular and cardiac physiology can reveal mechanisms of hypertension and clarify the clinical interpretation of exercise blood pressure.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction

Katherine S. S. Takvorian, Dongyu Wang, Paul Courchesne, Ramachandran S. S. Vasan, Emelia J. J. Benjamin, Susan Cheng, Martin G. G. Larson, Daniel Levy, Jennifer E. E. Ho

Summary: We identified 5 protein biomarkers associated with incident HFpEF, including NT-proBNP, growth differentiation factor-15, adrenomedullin, uncarboxylated matrix Gla protein, and C-reactive protein. We also found 14 biomarkers associated with incident HFrEF, including myeloperoxidase, resistin, and paraoxanase-1. These findings provide insights into similarities and differences in the development of HF subtypes.

CIRCULATION-HEART FAILURE (2023)

Article Peripheral Vascular Disease

Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma

M. Piazza, N. M. J. Hanssen, J. L. J. M. Scheijen, M. Vd Waarenburg, B. Caroccia, T. M. Seccia, C. D. A. Stehouwer, G. P. Rossi, C. G. Schalkwijk

Summary: This study investigated the association between serum AT1AA levels and serum MGO and AGE levels in APA patients, and found no significant correlation between these markers. Furthermore, no significant changes were observed in these markers after adrenalectomy in APA patients.

JOURNAL OF HUMAN HYPERTENSION (2023)

Article Health Care Sciences & Services

Estimating incidence of type 1 and type 2 diabetes using prevalence data: the SEARCH for Diabetes in Youth study

Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore

Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.

BMC MEDICAL RESEARCH METHODOLOGY (2023)

Review Oncology

Quad-shot-immunotherapy: quad-shot radiotherapy with pembrolizumab for advanced/recurrent head and neck cancer

Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu

Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.

FUTURE ONCOLOGY (2023)

Article Clinical Neurology

Evaluation of the transverse venous sinus with transcranial color-coded duplex

Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal

Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).

JOURNAL OF NEUROIMAGING (2023)

Article Endocrinology & Metabolism

Diabetes Complications and Cognitive Function in Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D'Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening

Summary: This study examined the relationship between diabetes complications and cognitive dysfunction in young adults with type 1 or type 2 diabetes. The results showed that hypoglycemia and peripheral neuropathy were associated with cognitive deficits in type 1 diabetes, while high blood pressure was associated with cognitive deficits in type 2 diabetes. These findings provide insights for targeting specific factors to mitigate cognitive issues in young people with diabetes.

PEDIATRIC DIABETES (2023)

Article Cardiac & Cardiovascular Systems

Association of healthy dietary patterns and cardiorespiratory fitness in the community

Michael Y. Mi, Priya Gajjar, Maura E. Walker, Patricia Miller, Vanessa Xanthakis, Venkatesh L. Murthy, Martin G. Larson, Ramachandran S. Vasan, Ravi Shah, Gregory D. Lewis, Matthew Nayor

Summary: This study explores the relationship between healthy dietary patterns and physical fitness in adults, as well as the biological connections between diet and fitness through circulating metabolites. The results indicate that a healthy diet is associated with greater physical fitness in middle-aged adults, and this relationship may be explained by favorable metabolic health.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2023)

Article Medicine, General & Internal

Social, Behavioral, and Metabolic Risk Factors and Racial Disparities in Cardiovascular Disease Mortality in US Adults: An Observational Study

Jiang He, Joshua D. Bundy, Siyi Geng, Ling Tian, Hua He, Xingyan Li, Keith C. Ferdinand, Amanda H. Anderson, Kirsten S. Dorans, Ramachandran S. Vasan, Katherine T. Mills, Jing Chen

Summary: The study examines the association between social, behavioral, and metabolic risk factors and cardiovascular disease (CVD) mortality, and whether there are racial differences in CVD mortality after accounting for these factors. The results show that social, behavioral, and metabolic risk factors are significantly associated with CVD mortality. After adjusting for these factors, the Black-White difference in CVD mortality diminishes and completely dissipates with adjustment for social determinants of health.

ANNALS OF INTERNAL MEDICINE (2023)

Article Cell Biology

Trends among platelet function, arterial calcium, and vascular function measures

Jason Cunha, Melissa V. Chan, Bongani B. Nkambule, Florian Thibord, Amber Lachapelle, Robin E. Pashek, Ramachandran S. Vasan, Jian Rong, Emelia J. Benjamin, Naomi M. Hamburg, Ming-Huei Chen, Gary F. Mitchell, Andrew D. Johnson

Summary: Arterial tonometry and vascular calcification measures are valuable in assessing cardiovascular disease (CVD) risk. This study examined the relationship between arterial tonometry, platelet function, arterial calcium, and aortic diameter. The results suggest that higher arterial calcium may be associated with increased platelet reactivity, while larger aortic diameter may be linked to lower platelet reactivity. These findings indicate the potential interplay between subclinical atherosclerosis, platelet activation, and vascular structure.

PLATELETS (2023)

Meeting Abstract Cardiac & Cardiovascular Systems

SLEEP DYSFUNCTION AFTER BREAST CANCER TREATMENT ASSOCIATED WITH LVEF DECLINE (WF-97415)

Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

Meeting Abstract Endocrinology & Metabolism

Diabetes Stigma, Clinical Outcomes, and Substance Use in Adolescents and Young Adults: the SEARCH for Diabetes in Youth Study

Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker

HORMONE RESEARCH IN PAEDIATRICS (2023)

No Data Available