Article
Medicine, General & Internal
Aleksander Nobis, Daniel Zalewski, Eliza Samaryn, Mateusz Maciejczyk, Anna Zalewska, Napoleon Waszkiewicz
Summary: Depression is a prevalent psychiatric disorder that significantly impacts individuals and public health worldwide. Recent research has focused on identifying biological markers to better understand the underlying mechanisms of depression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Mitchell R. White, I-Ni Hsieh, Xavier De Luna, Kevan L. Hartshorn
Summary: Innate immunity plays a crucial role in early defense against influenza A virus (IAV). Serum amyloid A (SAA1) is a key acute phase reactant that increases significantly during IAV infection, with potential effects on neutrophil activation and recruitment. Different variants of SAA1 have varying effects on phagocyte responses and interactions with IAV, suggesting a complex role for SAA in host defense mechanisms against IAV.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Preetha Shridas, Avery C. Patrick, Lisa R. Tannock
Summary: Epidemiological data show a positive correlation between serum amyloid A (SAA) levels and cardiovascular disease severity and mortality. Animal studies suggest a causal role for SAA in atherosclerosis development. In mice, suppressing SAA has been shown to reduce abdominal aortic aneurysm formation. Researchers aim to understand the pathway of SAA involvement in order to consider it as a therapeutic target for cardiovascular diseases.
Article
Medicine, General & Internal
Juan J. Gagliardino, Martin R. Salazar, Walter G. Espeche, Paula E. Tolosa Chapasian, Daniela Gomez Garizoain, Ricardo D. Olano, Rodolfo N. Stavile, Eduardo Balbin, Camilo Martinez, Betty C. Leiva Sisnieguez, Carlos E. Leiva Sisnieguez, Horacio A. Carbajal
Summary: Evaluation of arterial stiffness indicators in people with prediabetes and its possible pathogenesis showed a significant association with insulin resistance and metabolic syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ailing Ji, Andrea C. Trumbauer, Victoria P. Noffsinger, Frederick C. de Beer, Nancy R. Webb, Lisa R. Tannock, Preetha Shridas
Summary: Serum amyloid A (SAA) is predictive of cardiovascular disease (CVD) in humans and induces atherosclerosis in mice. However, the proatherogenic effects of SAA are masked by high-density lipoprotein (HDL), the major carrier of SAA. Cholesteryl ester transfer protein (CETP) remodels HDL, releasing SAA and restoring its proinflammatory activity. Inhibiting CETP may therefore benefit patients with high SAA levels.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Environmental Sciences
Mostafa M. Elhady, Sara A. Adly, Husam A. Elshebiny, Said S. Moselhy
Summary: This study evaluated the levels of serum S100B and amyloid beta in patients with organophosphate (OP) intoxication to determine their sensitivity and specificity in assessing the severity of neurological damage. The results showed a positive correlation between S100B and amyloid beta levels, while there was a negative correlation between pseudocholinesterase activity and both markers. The levels of S100B and amyloid beta were significantly elevated in the patient group compared to the control group. The diagnostic accuracy of S100B was found to be higher than that of amyloid beta in distinguishing between moderate and severe OP intoxication. These findings suggest that changes in S100B and amyloid beta levels are directly related to the severity of OP intoxication.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tingjie Yang, Ke Wan, Rizhen Song, Xinli Guo, Yuanwei Xu, Jie Wang, Qing Zhang, Kevin Michael Alexander, Ronglih Liao, Yucheng Chen
Summary: This study demonstrated that low serum HDL-C may indicate a poor prognosis for patients with light-chain amyloid cardiomyopathy, affecting patients' survival time.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiziana Bacchetti, Camilla Morresi, Gianna Ferretti, Anders Larsson, Torbjoern Akerfeldt, Michael Svensson
Summary: This study aimed to investigate the effects of exercise on HDL composition and functional properties in overweight/obese subjects. The results showed that exercise training improved HDL functionality in overweight/obese adults, without significant reduction in BMI or modifications of glucose and lipid biochemical parameters. The study also found a significant correlation between serum MPO/PON ratios, HDL redox activity and ox-LDLs.
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni
Summary: The presence of a pro-oxidant state in patients with schizophrenia may contribute to the higher risk of atherosclerosis and cardiovascular disease in this group. This study investigated the associations between paraoxonase-1 levels and oxidative stress in schizophrenia patients. The results suggest that alterations in paraoxonase-1 may reflect a pro-oxidant state in specific subgroups of patients with schizophrenia.
Article
Neurosciences
Feifei Ge, Lin Dong, Donglin Zhu, Xingjian Lin, Jingping Shi, Ming Xiao
Summary: Thyroid dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). This study found that even in euthyroid subjects, low levels of serum FT3 and TT3 are differentially associated with AD-specific CSF changes. Serum FT3 is a strong candidate for the differential diagnosis between AD continuum and non-AD dementia, benefiting the early diagnosis and effective management of AD patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Natalia Smierciak, Wirginia Krzysciak, Marta Szwajca, Paulina Karcz, Amira Bryll, Tadeusz J. Popiela, Paulina Donicz, Aleksander Turek, Veronika Aleksandrovych, Maciej Pilecki
Summary: This study used MRI scans and magnetic resonance spectroscopy to analyze the biochemical parameters in patients with schizophrenia. It found that patients with schizophrenia have decreased levels of high-density lipoproteins, lower resistance to oxidative stress, and slightly elevated sodium in the blood. The study also revealed significant positive correlations between serum high-density cholesterol and the anterior cingulate cortex in the brain. This is the first study to describe the impact of anterior cingulate disorder on high-density cholesterol levels in the development of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Javier Sanchez-Marco, Roberto Martinez-Beamonte, Alicia De Diego, Tania Herrero-Continente, Cristina Barranquero, Carmen Arnal, Joaquin Surra, Maria A. Navarro, Jesus Osada
Summary: This study found that the Txndc5 gene is associated with the development of fatty liver and its deficiency leads to increased body weight and liver enlargement. RNA-seq analysis revealed an overexpression of serum amyloid genes and increased levels of certain indicators in the plasma. Additionally, it was found that the gene regulates the nature of high-density lipoprotein particles and that HDL particles containing SAA are not particularly oxidized.
Article
Biochemistry & Molecular Biology
Beata Szlachta, Anna Birkova, Tomasz Wielkoszynski, Alicja Gospodarczyk, Beata Hubkova, Maria Dydon, Jolanta Zalejska-Fiolka
Summary: This study aims to investigate the impact of reductions in various body mass components on oxidative, glycemic, and lipid parameters in obese individuals. The results demonstrate that weight loss can decrease cardiovascular risk, improve oxidative status, and reduce markers of oxidative damage. However, the effects on glycemic state vary depending on the specific body mass components. Glycemic status plays a crucial role in weight reduction.
Article
Nutrition & Dietetics
Qianrang Zhu, Yue Dai, Jingxian Zhang, Wei Xie, Hui Zuo, Jian Zhang, Yonglin Zhou
Summary: The study examined the association between serum Zn concentrations and metabolic risk factors in Chinese children and adolescents. It found that lower serum Zn levels were more likely associated with a poor metabolic status, as evidenced by their negative association with FG and positive associations with TC, HDL-cholesterol, and LDL-cholesterol levels.
BRITISH JOURNAL OF NUTRITION
(2021)