Journal
OBESITY
Volume 21, Issue 10, Pages 2007-2013Publisher
WILEY
DOI: 10.1002/oby.20332
Keywords
-
Categories
Funding
- American Heart Association [09BGIA2060722]
- American Federation for Aging Research [8A0024]
- National Institute of Neurological Disorders and Stroke [R01NS75565]
- National Institute on Aging [F31AG040890]
Ask authors/readers for more resources
Objective: To examine the role of hypertension, hyperglycemia, and dyslipidemia in potentially accounting for obesity-related brain vulnerability in the form of altered cerebral neurochemistry. Design and Methods: Sixty-four adults, ages 40-60 years, underwent a health screen and proton magnetic resonance spectroscopy (H-1 MRS) of occipitoparietal gray matter to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI), and glutamate (Glu) relative to creatine (Cr). The causal steps approach and nonparametric bootstrapping were utilized to assess if fasting glucose, mean arterial pressure or peripheral lipid/lipoprotein levels mediate the relationship between body mass index (BMI) and cerebral neurochemistry. Results: Higher BMI was significantly related to higher mI/Cr, independent of age and sex. BMI was also significantly related to two of the proposed mediators, triglyceride, and HDL-cholesterol, which were also independently related to increased mI/Cr. Finally, the relationship between BMI and mI/Cr was significantly attenuated after inclusion of triglyceride and HDL-cholesterol into the model, one at a time, indicating statistical mediation. Conclusions: Higher triglyceride and lower HDL levels statistically account for the association between BMI and myo-inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available