Review
Cardiac & Cardiovascular Systems
Marco Guglielmo, Andrew Lin, Damini Dey, Andrea Baggiano, Laura Fusini, Giuseppe Muscogiuri, Gianluca Pontone
Summary: EAT and PCAT are not inert fat tissues, they secrete adipokines that have significant effects on cardiovascular health; PCAT inflammation is associated with CAD and cardiovascular events, and CCT has become a key technology for assessing EAT and PCAT.
Article
Cardiac & Cardiovascular Systems
Takashi Kataoka, Ken Harada, Akihito Tanaka, Tomohiro Onishi, Shun Matsunaga, Hiroshi Funakubo, Kazuhiro Harada, Tomoyuki Nagao, Norihiro Shinoda, Nobuyuki Marui, Kiyoshi Niwa, Hiroshi Tashiro, Yusuke Hitora, Kenji Furusawa, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Summary: The study found that Epicardial adipose tissue (EAT) volume is significantly associated with coronary artery spasm, while total abdominal adipose tissue (AAT) may not have a significant impact.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjun Fan, Yueqiao Si, Enhong Xing, Zengbin Feng, Zhenjiang Ding, Yixiang Liu, Chen Wei, Yanan Tian, Ying Zhang, Jingyi Liu, Lixian Sun
Summary: This study investigates the expression of novel adipocytokines and inflammatory cells infiltration in epicardial adipose tissue (EAT) and subcutaneous adipose tissue (SAT) between 27 coronary artery disease (CAD) and 21 non-CAD (NCAD) patients. The results showed dysregulation of novel adipocytokines and inflammatory cells infiltration in EAT, which could be important pathophysiological mechanisms and novelly promising medicating targets of CAD.
Article
Biochemistry & Molecular Biology
Zdenek Matloch, Milos Mraz, Barbora Judita Kasperova, Helena Kratochvilova, Petr Svoboda, Iveta Pleyerova, Katerina Reznickova, Sarah Norman, Daniel Hlavacek, Jakub Mahrik, Peter Ivak, Zdenka Lacinova, Ivan Netuka, Martin Haluzik
Summary: In this study, changes in serum CTRP3 and its gene expression in patients with CAD and T2DM undergoing cardiac surgery were examined. The results showed that decreased EAT mRNA levels of CTRP3 may contribute to higher risk of atherosclerosis in patients with CAD and T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Olga V. Gruzdeva, Yulia A. Dyleva, Ekaterina V. Belik, Maxim Y. Sinitsky, Aleksandr N. Stasev, Aleksandr N. Kokov, Natalia K. Brel, Evgenia O. Krivkina, Evgenia E. Bychkova, Roman S. Tarasov, Olga L. Barbarash
Summary: This study assessed the expression and secretion of adipocytokine genes in the adipose tissue of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. The results showed that epicardial fat depots in CAD patients exhibited more pronounced changes and increased pro-inflammatory activity compared to the group with heart defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Noura N. Ballasy, Anshul S. Jadli, Pariya Edalat, Sean Kang, Ali Fatehi Hassanabad, Karina P. Gomes, Paul W. M. Fedak, Vaibhav B. Patel
Summary: The study found that epicardial adipose tissue (EAT) treated with high glucose, high palmitate, and lipopolysaccharide released a large amount of proinflammatory cytokines, which may lead to EAT inflammation in patients with type 2 diabetes, causing coronary artery endothelial cell dysfunction.
Article
Biochemistry & Molecular Biology
Brendin Flinn, Christopher Adams, Nepal Chowdhury, Todd Gress, Nalini Santanam
Summary: Epicardial fat plays a key role in cardiovascular diseases, and the non-coding RNA and transcriptomic alterations of epicardial fat in coronary artery disease have been found to be unique. Analysis of microRNA and long non-coding RNA revealed sex-dependent mi/lncRNA changes in epicardial fat of patients with coronary artery disease. These changes are associated with inflammation, adipogenesis, cardiomyocyte apoptosis, atherosclerosis, and myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yasufumi Katanasaka, Ayumi Saito, Yoichi Sunagawa, Nurmila Sari, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Takehide Akimoto, Chikara Ueki, Mitsuru Kitano, Koji Hasegawa, Genichi Sakaguchi, Tatsuya Morimoto
Summary: This study investigated the expression of ANGPTL4 in epicardial adipose tissue (EAT) of patients with coronary artery disease (CAD). The results showed that the expression of ANGPTL4 was significantly increased in EAT of CAD patients and positively correlated with IL-1 beta. Additionally, non-obese CAD patients also exhibited increased expression of ANGPTL4 and IL-1 beta in EAT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Magali Barchuk, Patricia Ancel, Veronica Miksztowicz, Elisa Doukbi, Ljubica Svilar, Daniel Ynon, Juan Patricio Nogueira, Miguel Rubio, Laura Schreier, Anne Dutour, Jean Charles Martin, Benedicte Gaborit, Gabriela Berg
Summary: This study evaluated the relationship between lipoprotein lipase (LPL) activity, its regulators, and ceramides in epicardial adipose tissue (EAT) from patients with coronary artery disease (CAD). The results showed that LPL activity was higher in EAT from CAD patients, and EAT exhibited increased ceramide levels. The findings highlight the importance of LPL activity and these bioactive lipids in the different metabolic profile of EAT in CAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Immunology
Borek Foldyna, Thomas Mayrhofer, Markella Zanni, Asya Lyass, Radhika Barve, Julia Karady, Sara McCallum, Tricia H. Burdo, Kathleen Fitch, Kayla Paradis, Evelynne S. Fulda, Marissa R. Diggs, Gerald S. Bloomfield, Carlos D. Malvestutto, Carl J. Fichtenbaum, Judith A. Aberg, Judith S. Currier, Heather J. Ribaudo, Udo Hoffmann, Michael T. Lu, Pamela S. Douglas, Steven K. Grinspoon
Summary: This study investigated the relationship between pericoronary adipose tissue density and coronary inflammation and plaque in individuals with human immunodeficiency virus (HIV). The results showed that increased pericoronary adipose tissue density was associated with the prevalence and severity of coronary plaque, suggesting a link between coronary inflammation and coronary artery disease in people with HIV.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan
Summary: Epicardial adipose tissue (EAT) is a visceral fat deposit that is morphologically and physiologically connected to the myocardium and coronary arteries. It has cardioprotective characteristics, but under clinical processes, it can impact the heart and coronary arteries by secreting proinflammatory cytokines. The factors affecting this equilibrium are still not fully understood. This review focuses on the physiological and pathophysiological dimensions of EAT and its various clinical utilities.
Article
Physiology
Qian-Chen Wang, Zhen-Yu Wang, Qian Xu, Ruo-Bing Li, Guo-Gang Zhang, Rui-Zheng Shi
Summary: This study compared the histological and gene expression differences of epicardial adipose tissue (EAT) between patients with and without coronary artery disease (CAD). The CAD group showed larger epicardial adipocytes and a total of 747 differentially expressed genes (DEGs) were identified in CAD EAT, with more pro-inflammatory and immunological genes and pathways involved. Ten hub DEGs were also identified. EAT in CAD exhibits unique gene expression profiles and may play a key role in the pathological process of CAD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangbo Jin, Beibei Gao, Jiamin Zheng, Xueer Wu, Ning Zhang, Lijun Zhu, Xinyu Zhu, Jianchang Xie, Zhen Wang, Guoxin Tong, Jinyu Huang
Summary: This study found that epicardial adipose tissue (EAT) volume is significantly associated with the presence and severity of cardiovascular disease in Chinese patients, independent of traditional risk factors and coronary artery calcium. When combined with obstructive coronary artery disease, EAT volume significantly improves the diagnostic performance for cardiovascular disease, suggesting that EAT could be a reliable noninvasive indicator of hemodynamically significant CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Olga A. Kharitonova, Vladimir V. Evtushenko, Alla A. Boshchenko
Summary: The study compared the morphological characteristics of epicardial adipose tissue (EAT) adipocytes and their sensitivity to insulin with coronary artery disease (CAD) severity, finding a relationship between the size and degree of hypertrophy of epicardial adipocytes and CAD severity. Insulin resistance of adipocytes may mediate this relationship.
Article
Pharmacology & Pharmacy
Kenan Demir, Ahmet Avci, Serpil Ergulu Esmen, Abdullah Tuncez, Muhammed Ulvi Yalcin, Ahmet Yilmaz, Serra Yilnnaz, Bulent Behlul Altunkeser
Summary: AS patients have higher EATT and arterial stiffness parameters compared to the control group, indicating a higher risk of atherosclerosis and cardiovascular disease. Furthermore, the study demonstrates a significant relationship between PWV and EATT, age, and central blood pressure in AS patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Public, Environmental & Occupational Health
Congying Xia, Mieneke Rook, Gert Jan Pelgrim, Grigory Sidorenkov, Hendrik J. Wisselink, Jurjen N. van Bolhuis, Peter M. A. van Ooijen, Jiapan Guo, Matthijs Oudkerk, Harry Groen, Maarten van den Berge, Pim van der Harst, Hildebrand Dijkstra, Marleen Vonder, Marjolein A. Heuvelmans, Monique D. Dorrius, Peter Paul De Deyn, Geertruida H. de Bock, Aafje Dotinga, Rozemarijn Vliegenthart
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pandji Triadyaksa, Dirkjan Kuijpers, Tugba Akinci D'Antonoli, Jelle Overbosch, Mieneke Rook, J. Martijn van Swieten, Matthijs Oudkerk, Paul E. Sijens
EUROPEAN RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hendrik Joost Wisselink, Gert Jan Pelgrim, Mieneke Rook, Maarten van den Berge, Kees Slump, Yeshu Nagaraj, Peter van Ooijen, Matthijs Oudkerk, Rozemarijn Vliegenthart
BRITISH JOURNAL OF RADIOLOGY
(2020)
Article
Oncology
Xiaonan Cui, Marjolein A. Heuvelmans, Shuxuan Fan, Daiwei Han, Sunyi Zheng, Yihui Du, Yingru Zhao, Grigory Sidorenkov, Harry J. M. Groen, Monique D. Dorrius, Matthijs Oudkerk, Geertruida H. de Bock, Rozemarijn Vliegenthart, Zhaoxiang Ye
CLINICAL LUNG CANCER
(2020)
Article
Computer Science, Interdisciplinary Applications
Sunyi Zheng, Jiapan Guo, Xiaonan Cui, Raymond N. J. Veldhuis, Matthijs Oudkerk, Peter M. A. van Ooijen
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pandji Triadyaksa, Matthijs Oudkerk, Paul E. Sijens
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Oncology
Daiwei Han, Marjolein A. Heuvelmans, Carlijn M. van der Aalst, Lisa H. van Smoorenburg, Monique D. Dorrius, Mieneke Rook, Kristiaan Nackaerts, Joan E. Walter, Harry J. M. Groen, Rozemarijn Vliegenthart, Harry J. de Koning, Matthijs Oudkerk
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Medicine, General & Internal
H. J. de Koning, C. M. van der Aalst, P. A. de Jong, E. T. Scholten, K. Nackaerts, M. A. Heuvelmans, J. -W. J. Lammers, C. Weenink, U. Yousaf-Khan, N. Horeweg, S. van't Westeinde, M. Prokop, W. P. Mali, F. A. A. Mohamed Hoesein, P. M. A. van Ooijen, J. G. J. V. Aerts, M. A. den Bakker, E. Thunnissen, J. Verschakelen, R. Vliegenthart, J. E. Walter, K. ten Haaf, H. J. M. Groen, M. Oudkerk
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihui Du, Qiong Li, Grigory Sidorenkov, Marleen Vonder, Jiali Cai, Geertruida H. de Bock, Yu Guan, Yi Xia, Xiuxiu Zhou, Di Zhang, Mieneke Rook, Rozemarijn Vliegenthart, Marjolein A. Heuvelmans, Monique D. Dorrius, P. M. A. van Ooijen, Harry J. M. Groen, Pim van der Harst, Yi Xiao, Zhaoxiang Ye, Xueqian Xie, Wenjing Wang, Matthijs Oudkerk, Li Fan, Shiyuan Liu
Summary: This study aims to compare the screening performance of volume-based and diameter-based management of CT-detected lung nodules, in order to improve early detection of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) while reducing unnecessary referrals through quantitative assessment of CT imaging biomarkers.
ACADEMIC RADIOLOGY
(2021)
Review
Multidisciplinary Sciences
M. Wielema, M. D. Dorrius, R. M. Pijnappel, G. H. De Bock, P. A. T. Baltzer, M. Oudkerk, P. E. Sijens
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthijs Oudkerk, Harry R. Buller, Dirkjan Kuijpers, Nick van Es, Sytse F. Oudkerk, Theresa McLoud, Diederik Gommers, Jaap van Dissel, Hugo ten Cate, Edwin J. R. van Beek
Review
Oncology
Yihui Du, Xiaonan Cui, Grigory Sidorenkov, Harry J. M. Groen, Rozemarijn Vliegenthart, Marjolein A. Heuvelmans, Shiyuan Liu, Matthijs Oudkerk, Geertruida H. de Bock
TRANSLATIONAL LUNG CANCER RESEARCH
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaonan Cui, Shuxuan Fan, Marjolein A. Heuvelmans, Daiwei Han, Yingru Zhao, Harry J. M. Groen, Monique D. Dorrius, Matthijs Oudkerk, Geertruida H. de Bock, Rozemarijn Vliegenthart, Zhaoxiang Ye
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Sabine J. A. M. Denissen, Carlijn M. van der Aalst, Marleen Vonder, Jan Willem C. Gratama, Henk J. Adriaansen, Dirkjan Kuijpers, Jeanine E. Roeters van Lennep, Rozemarijn Vliegenthart, Pim van der Harst, Richard L. Braam, Paul R. M. van Dijkman, Matthijs Oudkerk, Harry J. de Koning
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Sabine J. A. M. Denissen, Carlijn M. van der Aalst, Marleen Vonder, Jan Willem C. Gratama, Henk J. Adriaansen, Dirkjan Kuijpers, Jeanine E. Roeters van Lennep, Rozemarijn Vliegenthart, Pim van der Harst, Richard L. Braam, Paul R. M. van Dijkman, Matthijs Oudkerk, Harry J. de Koning
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)