Article
Medicine, Research & Experimental
Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Kolawole A. Olofinsan, Sunday O. Oyedemi, Chika I. Chukwuma, Adeline Lum Nde, Md. Shahidul Islam
Summary: Reduced glucose uptake and utilization has been linked to obesity and its complications. This study found that cannabinoid-stimulated glucose uptake increased antioxidative activities, modulated cholinergic and purinergic dysfunctions, and improved glucose-lipid homeostasis in adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
He Zhang, Erdu Ren, Rongying Xu, Yong Su
Summary: This study investigated the effects of short-term intravenous sodium butyrate (SB) administration on the metabolism of muscle and adipose tissue in pigs. The results showed that systemic butyrate displayed discriminative metabolic regulation in muscle and adipose tissues, affecting amino acid metabolism pathways, glucose catabolism, and lipolysis. The findings support the role of butyrate in regulating metabolism and energy metabolism as a metabolite of bacterial fermentation.
Article
Biochemistry & Molecular Biology
Gege Liu, Lixia Chen, Haining Tian, Guoliang Sun, Fulei Wei, Yuqiong Meng, Rui Ma
Summary: The study found that triploid rainbow trout can adapt to different levels of dietary lipids by coordinating metabolism in different tissues. The liver plays a key role in lipid metabolism, with low lipid diets leading to increased lipid transport and glycolysis. Moderate lipid intake enhances lipid uptake and lipogenesis in muscle, while excess lipids are preferentially stored in abdominal adipose tissue through coordinated fatty acid uptake and de novo synthesis.
Article
Biochemistry & Molecular Biology
Yingxi Xu, Tianhao Yu, Guojing Ma, Lixia Zheng, Xuehan Jiang, Fan Yang, Zhuo Wang, Na Li, Zheng He, Xiaoyu Song, Deliang Wen, Juan Kong, Yang Yu, Liu Cao
Summary: Berberine promotes the distribution of brown adipose tissue and thermogenesis, leading to reduced body weight and insulin resistance in high-fat diet mice. It activates the energy metabolic sensing pathway and increases the expression of thermogenic proteins in adipose tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Baojun Sun, Hitomi Maruta, Yun Ma, Hiromi Yamashita
Summary: Taurine is an abundant free amino acid in mammalian tissues that plays a role in skeletal muscle function and exercise capacity. This study investigated the mechanism of taurine function in skeletal muscles by examining the effects of short-term administration of taurine on rats and L6 cells. The results suggest that taurine modulates skeletal muscle function by activating AMP-activated protein kinase through the calcium signaling pathway, leading to the expression of genes and proteins associated with mitochondrial and respiratory metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Eva Rial-Pensado, Veronica Rivas-Limeres, Carmen Grijota-Martinez, Amanda Rodriguez-Diaz, Valentina Capelli, Olga Barca-Mayo, Ruben Nogueiras, Jens Mittag, Carlos Dieguez, Miguel Lopez
Summary: Thyroid hormones play a major role in regulating energy balance and BAT thermogenesis, and these actions are influenced by environmental temperature.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kristina Sharlo, Irina Lvova, Sergey Tyganov, Ksenia Zaripova, Svetlana Belova, Tatiana Kostrominova, Boris Shenkman, Tatiana Nemirovskaya
Summary: Skeletal muscle abnormalities and atrophy during unloading can be attributed to excess calcium accumulation, which may be caused by the inhibition of SERCA activity. Treating with SERCA activator CDN1163 can reduce calcium level, thus preventing negative consequences. In this study, unloading for 7 days led to increased fatigue, decreased mitochondrial markers and slow-type myosin, and disrupted calcium homeostasis in Soleus muscle. These changes were prevented by SERCA activation but had no effect on muscle atrophy.
Article
Agriculture, Dairy & Animal Science
Madison N. Myers, Ursula Abou-Rjeileh, Miguel Chirivi, Jair Parales-Giron, Adam L. Lock, Joseph Tam, Maya Zachut, Andres Contreras
Summary: Amplified adipose tissue (AT) lipolysis and suppressed lipogenesis characterize the periparturient period of dairy cows. Activation of cannabinoid-1 receptor (CB1R) can reduce lipolysis and enhance lipogenesis in nonlactating non-gestating (NLNG) cows, but it has no direct effect on lipolysis in periparturient cows. CB1R activation can enhance adipogenesis and lipogenesis in the AT of NLNG cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nan Zhang, Chao Liu, Yi Zhang, Dongmei Xu, Li Gui, Yunxia Lu, Qiu Zhang
Summary: Liraglutide reduces body mass and adipocyte size in type 2 diabetes mice by promoting secretion of FGF21, activating AMPK pathway, and inhibiting TG synthesis in an autocrine manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Jie Bai, Tao Yang, Yaping Zhou, Wei Xu, Shuai Han, Tianyi Guo, Lingfeng Zhu, Dandan Qin, Yi Luo, Zuomin Hu, Xiaoqi Wu, Feijun Luo, Bo Liu, Qinlu Lin
Summary: Changes in eating habits have led to a significant increase in obesity. Octacosanol has been found to reduce lipid levels in high-fat diet-induced obese mice by modulating lipid metabolism-related signal pathways.
Article
Biochemistry & Molecular Biology
Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Soonghee Chung, Ju-Tae Sohn
Summary: This study aimed to examine the effect of lipid emulsion on the vasodilation induced by a toxic dose of amlodipine in isolated rat aorta and elucidate its mechanism, with a particular focus on nitric oxide. The results showed that lipid emulsion enhanced amlodipine-induced vasodilation and inhibited amlodipine-induced cyclic guanosine monophosphate (cGMP) production. Additionally, lipid emulsion reversed the phosphorylation of eNOS induced by amlodipine. These findings suggest that lipid emulsion attenuates amlodipine-induced vasodilation through inhibiting nitric oxide release in isolated rat aorta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yan-Nan You, Qiong-Qiong Xing, Xia Zhao, Jian-Jian Ji, Hua Yan, Tao Zhou, Ying-Mei Dong, Li-Shun Ren, Shu-Ting Hou, Yuan-Yuan Ding
Summary: The study found that Gu-Ben-Fang-Xiao decoction can regulate lipid metabolism in asthma patients, maintain lipid homeostasis on the lung surface, and alleviate asthma. The specific mechanism may be related to regulating fatty acid metabolism and activating the AMP-activated protein kinase pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Physiology
Ruping Pan, Yong Chen
Summary: Exercise plays a critical role in regulating oxidative metabolism, influencing ROS levels and mitigating oxidative stress. Proper exercise can help reduce ROS levels, especially in pathological conditions. Beige and brown adipose tissues are key players in this process, contributing to metabolic balance and protection against oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shanying Yan, Yangli Pei, Jiju Li, Zhonglin Tang, Yalan Yang
Summary: Circular RNAs (circRNAs) are a highly conserved and specifically expressed class of covalently closed non-coding RNAs, which can function as miRNA sponges, protein scaffolds, and regulatory factors. They play various roles in development and other biological processes in mammals. Recent advances in circRNA-related studies of skeletal muscle and adipose in farm animals have been highlighted, including their biogenesis, properties, biological functions, and regulatory mechanisms. Furthermore, their effects on economic traits such as meat yield and quality have been comprehensively summarized. CircRNAs are proposed as potential novel targets to improve meat yield and quality traits during animal breeding.
Article
Genetics & Heredity
Lili Du, Tianpeng Chang, Bingxing An, Mang Liang, Tianyu Deng, Keanning Li, Sheng Cao, Yueying Du, Xue Gao, Lingyang Xu, Lupei Zhang, Junya Li, Huijiang Gao
Summary: Genetics and environment play a role in fat deposition traits, affecting meat quality, growth rate, and energy metabolism in livestock. However, the molecular mechanism of fat deposition in beef cattle is not fully understood. This study analyzed transcriptomics and lipid metabolomics of different adipose tissues in Huaxi cattle, uncovering gene expression patterns and metabolite differences. Several candidate genes, such as SCD, ELOVL6, ACACA, and FABP7, were found to regulate fat deposition by influencing the levels of fatty acids and triglycerides. These findings provide valuable insights for future research on fat deposition in beef cattle.