Article
Immunology
Javier Martinez-Sanz, Sergio Serrano-Villar, Alfonso Muriel, Lucio J. Garcia Fraile, Eva Orviz, Alvaro Mena de Cea, Antoni A. Campins, Santiago Moreno
Summary: This study investigated the metabolic effects of switching from TDF to TAF. The results showed an increase in weight, total cholesterol, and triglycerides after switching to TAF, with no observed increase in obesity or metabolic-related diseases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Ville-Petteri Makinen, Mari Karsikas, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This study investigated metabolic ageing trends in two large cohorts using new methods, revealing that women gained more weight but showed milder metabolic changes compared to men. Temporal sex differences were observed for certain metabolic markers, and individuals with different weight changes exhibited divergent patterns in certain metabolic measures.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Sofia Christakoudi, Panagiota Pagoni, Pietro Ferrari, Amanda J. Cross, Ioanna Tzoulaki, David C. Muller, Elisabete Weiderpass, Heinz Freisling, Neil Murphy, Laure Dossus, Renee Turzanski Fortner, Antonio Agudo, Kim Overvad, Aurora Perez-Cornago, Timothy J. Key, Paul Brennan, Mattias Johansson, Anne Tjonneland, Jytte Halkjaer, Marie-Christine Boutron-Ruault, Fanny Artaud, Gianluca Severi, Rudolf Kaaks, Matthias B. Schulze, Manuela M. Bergmann, Giovanna Masala, Sara Grioni, Vittorio Simeon, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Charlotta Rylander, Kristin Benjaminsen Borch, J. Ramon Quiros, Miguel Rodriguez-Barranco, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Isabel Drake, Tanja Stocks, Christel Haggstrom, Sophia Harlid, Merete Ellingjord-Dale, Elio Riboli, Konstantinos K. Tsilidis
Summary: The study found that weight gain in middle adulthood was positively associated with multiple cancers, supporting avoiding weight gain and encouraging weight loss.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Inge Verkouter, Raymond Noordam, Nellie Y. Loh, Ko Willems van Dijk, Peter L. Zock, Dennis O. Mook-Kanamori, Saskia le Cessie, Frits R. Rosendaal, Fredrik Karpe, Costantinos Christodoulides, Renee de Mutsert
Summary: The study showed that adult weight gain is associated with specific metabolomic alterations, including an increase in adipocyte volume and changes in lipoprotein categories. There is a significant positive correlation between weight gain and adipocyte volume.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Georgios Schoretsanitis, Celine Dubath, Claire Grosu, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Nicolas Ansermot, Severine Crettol, Frederik Vandenberghe, Franziska Gamma, Armin Gunten, Kerstin Jessica Plessen, Erich Seifritz, Philippe Conus, Chin B. Eap
Summary: This study assessed the effects of olanzapine on metabolic parameters, and found that high-dose olanzapine treatment may lead to early weight gain, while low-dose treatment is associated with increases in blood lipids and blood pressure. Treatment duration and co-prescription of other medications were also found to be related to weight gain.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Pontus Henriksson, Jairo H. Migueles, Emmie Soderstrom, Johanna Sandborg, Ralph Maddison, Marie Lof
Summary: This study aimed to investigate the associations of user engagement with a pregnancy mobile health intervention (HealthyMoms app) with gestational weight gain, diet quality, and physical activity. The results showed that higher engagement in self-monitoring features, particularly in physical activity, was linked to lower gestational weight gain and improved diet quality.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Hae-Jin Ko, Yoon Jeong Cho, Kyoung-Kon Kim, Jee-Hyun Kang, Young-Sang Kim, Ji-Hee Haam, Yang-Im Hur, Hye-In Choi, Kyu Rae Lee, Jung Ha Park, Soo Hyun Cho, Jong-Koo Kim, Taesic Lee, Myung-Jae Seo, Yeong Sook Yoon, Yoobin Seo, Ga Eun Nam, Sun Hyun Kim
Summary: Metabolic syndrome and its components worsened after the strengthening of social distancing regulations, although there were no significant increases in anthropometric indices and body fat levels.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Stefanie N. Hinkle, Sunni L. Mumford, Katherine L. Grantz, Pauline Mendola, James L. Mills, Edwina H. Yeung, Anna Z. Pollack, Sonia M. Grandi, Rajeshwari Sundaram, Yan Qiao, Enrique F. Schisterman, Cuilin Zhang
Summary: Gestational weight change is associated with mortality over 50 years later, with sustained excessive or reduced weight being associated with increased risk of cardiovascular and diabetes-related deaths.
Article
Geriatrics & Gerontology
Megumi Tsubota-Utsugi, Kozo Tanno, Naomi Takahashi, Toshiyuki Onoda, Yuki Yonekura, Masaki Ohsawa, Shuko Takahashi, Toru Kuribayashi, Ryo Itabashi, Fumitaka Tanaka, Koichi Asahi, Shinichi Omama, Kuniaki Ogasawara, Yasushi Ishigaki, Fumiaki Takahashi, Akemi Soma, Nobuyuki Takanashi, Kiyomi Sakata, Takayoshi Ohkubo, Akira Okayama
Summary: There is a significant association between weight change and disability risk in older community-dwelling Japanese adults. Sizable weight loss and weight loss are significant predictors of disability onset, while sizable weight gain is associated with severe disability. The associations between weight change and disability risk are more pronounced in the unhealthy lifestyle and lower initial normal body mass index groups.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This population-based prospective cohort study found no association between vitamin D levels and changes in weight and waist circumference at 5- and 10-year follow-up.
Article
Multidisciplinary Sciences
Anna Tylutka, Barbara Morawin, Lukasz Walas, Marta Michalek, Anna Gwara, Agnieszka Zembron-Lacny
Summary: The diagnosis of metabolic syndrome (MetS) focuses on assessing risk factors and markers of systemic inflammation may also be included in its definition. This study evaluates low-grade inflammation in older adults with MetS and attempts to identify new predictors through ROC Curve analysis. Participants were divided into two groups based on MetS criteria, and their health status was assessed using medical records.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Yuqing Ding, Xin Xu, Ting Tian, Chengxiao Yu, Xinyuan Ge, Jiaxin Gao, Jing Lu, Zijun Ge, Tao Jiang, Yue Jiang, Hongxia Ma, Ci Song, Zhibin Hu
Summary: Early or middle and late adulthood weight gain is associated with an increased risk of NAFLD, and effective weight intervention can prevent a large proportion of NAFLD cases.
Article
Public, Environmental & Occupational Health
Kevin C. Mathias, Yuchen Wu, Donald F. Stewart, Denise L. Smith
Summary: This study found that younger firefighters tend to gain weight more significantly compared to older firefighters, with younger firefighters also being more likely to gain weight and less likely to lose weight. Smaller weight gains were associated with age and BMI, with the smallest increases observed in overweight and obese firefighters over 45 years old.
Article
Thermodynamics
Jianping Zhou, Feilong Song, Yun Wu, Shida Xu, Xingkui Yang, Peng Cheng, Yinghong Li
Summary: In this study, the total pressure gains of a rotating detonation engine using kerosene and hot air were measured for different combinations. The study found that the total pressure gain tends to increase with the decrease of certain ratios. A pressure gain model was developed to describe the variation of total pressure gain with the ratios and a parameter called Qv was introduced to consider other factors. A comparison was also made with other measurement methods.
COMBUSTION AND FLAME
(2023)
Article
Psychology, Clinical
Anouk F. J. Geraets, Sebastian Kohler, Laura W. M. Vergoossen, Walter H. Backes, Coen D. A. Stehouwer, Frans Rj Verhey, Jacobus Fa Jansen, Thomas T. van Sloten, Miranda T. Schram
Summary: This study investigated the association between markers of white matter connectivity and depressive symptoms. The findings suggest that fewer white matter connections may contribute to prevalent depressive symptoms and its persistence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xiaodi Zhang, Jean L. J. M. Scheijen, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk
Summary: In this study, we found that the formation of postprandial methylglyoxal (MGO) in plasma and tissues originates from exogenous glucose and the increase in plasma MGO concentration leads to a fast formation of MGO-derived advanced glycation endproducts (AGEs).
Article
Sport Sciences
Tuija Leskinen, Valeria Lima Passos, Pieter C. Dagnelie, Hans H. C. M. Savelberg, Bastiaan E. De Galan, Simone J. P. M. Eussen, Coen D. A. Stehouwer, Sari Stenholm, Annemarie Koster
Summary: This study aimed to identify physical activity patterns and their association with cardiometabolic biomarkers. The results showed that individuals who engaged in moderate to high levels of physical activity daily had the most favorable cardiometabolic profile.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Rheumatology
R. Raadsen, R. Agca, M. Boers, V. P. van Halm, M. J. L. Peters, Y. Smulders, J. W. J. Beulens, M. T. Blom, C. D. A. Stehouwer, A. E. Voskuyl, W. F. Lems, M. T. Nurmohamed
Summary: This study investigated the cardiovascular disease (CVD) in rheumatoid arthritis (RA) patients over a 20-year follow-up, with a focus on patients without prevalent CVD. The results showed that the increased risk of CVD in RA patients without prevalent CVD is mainly due to the presence of traditional risk factors rather than RA itself.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Nutrition & Dietetics
Kim Maasen, Simone J. P. M. Eussen, Pieter C. Dagnelie, Coen D. A. Stehouwer, Antoon Opperhuizen, Marleen M. J. van Greevenbroek, Casper G. Schalkwijk
Summary: The intake of dicarbonyls, such as methylglyoxal, glyoxal, and 3-deoxyglucosone, in the diet is associated with improved insulin sensitivity and a lower prevalence of newly diagnosed type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Peripheral Vascular Disease
Floor M. E. G. Steegh, Anke. A. A. Keijbeck, Patrick. A. A. de Hoogt, Timo Rademakers, Alfons J. H. M. Houben, Koen. D. D. Reesink, Coen D. A. Stehouwer, Mat J. A. P. Daemen, Carine J. Peutz-Kootstra
Summary: Patients with CKD have an increased risk for cardiovascular morbidity and mortality. Renal and systemic capillary rarefaction occurs independently of the cause of renal function decline. Maintaining capillary integrity and homeostasis is crucial in the prevention and management of renal and cardiovascular disease.
Correction
Clinical Neurology
Anouk F. J. Geraets, Miranda T. Schram, Jacobus F. A. Jansen, Walter H. Backes, Casper G. Schalkwijk, Coen D. A. Stehouwer, Martin P. J. van, Simone J. P. M. Eussen, Jeroen P. Kooman, Frans R. J. Verhey, Sebastian Kohler
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Frank C. T. van der Heide, Sara Mokhtar, Anjani Khanna, Mozhda Said, Ronald M. A. Henry, Abraham A. Kroon, Pieter C. Dagnelie, Simone J. P. M. Eussen, Tos T. J. M. Berendschot, Jan S. A. G. Schouten, Miranda T. Schram, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Anke Wesselius, Hans H. C. M. Savelberg, Nicolaas C. Schaper, Carroll A. B. Webers, Coen D. A. Stehouwer
Summary: This study found significant associations between dementia risk factors (such as hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) and lower retinal sensitivity and retinal nerve fiber layer thickness. These findings suggest that retinal neural indices may serve as biomarkers for monitoring therapeutic strategies aimed at preventing early-stage cerebral neurodegeneration and dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Nutrition & Dietetics
Elena C. Tore, Simone J. P. M. Eussen, Nasser E. Bastani, Pieter C. Dagnelie, Amany K. Elshorbagy, Pol Grootswagers, Viktor Kozich, Thomas Olsen, Helga Refsum, Kjetil Retterstol, Coen D. A. Stehouwer, Emma T. K. Stolt, Kathrine J. Vinknes, Marleen M. J. van Greevenbroek
Summary: The study aimed to investigate the influence of dietary intake and nutrients on plasma amino acid concentrations. The results showed that intake of total amino acids and total proteins was positively associated with plasma tCys and cystathionine, with stronger associations in women and those with normal body weight. Higher intake of cysteine and plant proteins was associated with lower plasma tHcy and higher cystathionine. Higher methionine intake was associated with lower plasma tGSH, whereas cysteine intake was positively associated with tGSH. Higher intake of methionine and animal proteins was associated with higher plasma taurine. Better diet quality was consistently related to lower plasma tHcy concentrations, but it was not associated with the other SAAs.
JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
E. J. Vandercappellen, A. Koster, H. H. C. M. Savelberg, S. J. P. M. Eussen, P. C. Dagnelie, M. T. Schram, M. M. J. van Greevenbroek, A. Wesselius, J. P. Kooman, A. A. Kroon, R. M. A. Henry, C. D. A. Stehouwer
Summary: This study analyzed the association between physical activity and sedentary time with cardiac biomarkers and found that high-intensity physical activity may be associated with lower levels of NT-proBNP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Ioannis N. Boletis, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Bastiaan E. de Galan, Hans H. C. M. Savelberg, Annemarie Koster, Anke Wesselius, Vassiliki Benetou
Summary: This study examined the association of physical activity (PA) and sedentary behavior (SB) with endothelial dysfunction (ED) in individuals with different kidney function status. The results showed that PA duration was inversely associated with ED in both individuals with normal kidney function and those with chronic kidney disease, while longer sedentary bouts were associated with greater endothelial dysfunction in chronic kidney disease.
Article
Cardiac & Cardiovascular Systems
Nikki C. C. Werkman, Johanna H. M. Driessen, Coen D. A. Stehouwer, Peter Vestergaard, Nicolaas C. Schaper, Joop P. Van den Bergh, Johannes T. H. Nielen
Summary: The study found that current use of SGLT2-Is was not associated with an increased risk of LLA, while current use of GLP1-RAs was linked to a lower risk of LLA. The risk of DFU was similar with both types of medications.
CARDIOVASCULAR DIABETOLOGY
(2023)
Letter
Geriatrics & Gerontology
Astrid D. H. M. Brys, Coen D. A. Stehouwer, Christina van de Weijer, Fabienne Magdelijns
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Paul W. Franks, William T. Cefalu, John Dennis, Jose C. Florez, Chantal Mathieu, Robert W. Morton, Martin Ridderstrale, Henrik H. Sillesen, Coen D. A. Stehouwer
Summary: Cardiometabolic disease poses a major threat to global health. Precision medicine has the potential to reduce the burden of this disease cluster and improve evidence-based medicine. It requires a well functioning system involving various stakeholders and relies on powerful computing infrastructure and research methods for analysis of large-scale data.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Neuroimaging
Jennifer Monereo-Sanchez, Jacobus F. A. Jansen, Sebastian Kohler, Martin P. J. van Boxtel, Walter H. Backes, Coen D. A. Stehouwer, Abraham A. Kroon, Jeroen P. Kooman, Casper G. Schalkwijk, David E. J. Linden, Miranda T. Schram
Summary: The study found that diabetes and different stages of hyperglycemia are associated with tissue volume differences in specific subfields of the hippocampus. This research provides a potential opportunity for early prevention of brain diseases.
NEUROIMAGE-CLINICAL
(2023)