Article
Public, Environmental & Occupational Health
Xi Yang, Kaushik Chattopadhyay, Richard Hubbard, Jia-Lin Li, Li Li, Yi Lin
Summary: A 36-month weight management programme in Ningbo, China showed that participants achieved significant initial weight loss at 3 months and maintained the weight loss during 33-month follow-ups. At 36 months, a certain percentage of participants achieved 5%, 10%, and 15% weight loss. The programme is suggested to benefit overweight and obese adults in reducing body weight and maintaining long-term weight loss.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Farah J. Alsharif, Yara A. Almuhtadi
Summary: With the global prevalence of obesity increasing dramatically, it has become a serious public health threat associated with comorbid conditions and psychological disorders. While lifestyle interventions and dietary adjustments may help with weight loss, maintaining these changes long-term can be challenging. Spices like turmeric, ginger, and pepper have shown promise in obesity management, with curcumin in particular gaining interest for its health benefits. Studies have shown potential favorable effects of curcumin supplementation on anthropometric indices, warranting further investigation for overweight or obese adults.
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Samaneh Zolghadri, Armand Cholewka, Wojciech Myslinski
Summary: Obesity is a disease caused by the accumulation of fat, and dietary intervention is the primary treatment. Intermittent energy restriction diets have been proven effective for weight loss and have beneficial effects on metabolic parameters. This provides an alternative option for individuals who cannot adhere to continuous dietary restrictions.
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Ivan Ozvald, Dragan Bozicevic, Lidija Duh, Ivana Vinkovic Vrcek, Ivan Pavicic, Ana-Marija Domijan, Mirta Milic
Summary: The study evaluated severely obese patients after a very-low-calorie diet (VLCD) and found that VLCDs can decrease weight, improve lipid profiles, and reduce DNA damage, providing a basis for individualized monitoring and treatment.
Review
Nutrition & Dietetics
Yutong Shi, Kyohsuke Wakaba, Kosuke Kiyohara, Fumi Hayashi, Kazuyo Tsushita, Yoshio Nakata
Summary: This study aimed to evaluate the effectiveness of web-based interventions for weight change in overweight and obese adults. The analysis of 97 articles showed that components such as social support, self-monitoring, information about health consequences, and goal setting played important roles in achieving effectiveness. The study demonstrated that web-based interventions have significant effects on weight change in individuals with overweight and obesity.
Article
Medicine, General & Internal
Samira M. Almalki, Nasser M. Al-Daghri, Mariam Eid Al-Juhani, Hanan A. Alfawaz
Summary: Background: Obesity is a chronic and inflammatory disease resulting from interactions between genes and environmental factors. Probiotics have shown potential as a supplementation for reducing obesity. However, limited studies have been conducted on human subjects in this field. Therefore, this study aims to investigate the anti-obesity effect of probiotic supplementation.
Article
Endocrinology & Metabolism
Milina Tancic-Gajic, Miodrag Vukcevic, Miomira Ivovic, Ljiljana V. Marina, Zorana Arizanovic, Ivan Soldatovic, Milos Stojanovic, Aleksandar Dogo, Aleksandra Kendereski, Svetlana Vujovic
Summary: The study suggests that obstructive sleep apnea is associated with lower total and free testosterone levels in severely obese men. This finding indicates a potential impact of sleep disorders on sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher S. Digesu, Daniel Ospina-Delgado, Juan Ascanio, Adnan Majid, Mihir S. Parikh, Sidhu P. Gangadharan, Jennifer L. Wilson
Summary: Obese patients achieve similar improvement in HRQOL and functional capacity with comparable morbidity after TBP as nonobese patients. Obesity should not preclude patients with severe symptomatic excessive central airway collapse from TBP.
ANNALS OF THORACIC SURGERY
(2022)
Article
Orthopedics
David C. Landy, Jonathan D. Grabau, K. Keely Boyle, Michael P. Ast, James A. Browne, Cale A. Jacobs, Stephen T. Duncan, Eric M. Hecht
Summary: This study explores the self-reported health of US adults with severe obesity and osteoarthritis (OA). About 64% of participants rated their health as good or better, and physical functioning was found to be a strong predictor of self-reported health.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: Neck fat is associated with obesity and neck circumference in adolescents, with females having more neck fat than males. However, it does not appear to correlate with the presence and severity of obstructive sleep apnea syndrome (OSAS).
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: The study found that neck fat is associated with obesity and neck circumference in adolescents, with females having significantly greater neck fat than males. However, neck fat does not appear to correlate with the presence and severity of OSAS.
Article
Endocrinology & Metabolism
Joanna MacEwan, Hong Kan, Kevin Chiu, Jiat Ling Poon, Shraddha Shinde, Nadia N. Ahmad
Summary: The study found that despite the availability of newer anti-obesity medications, their utilization remains low in the United States. Users of these medications generally had higher healthcare costs, achieved better weight loss results, while non-users experienced weight gain over the past year. Factors such as depression, dyslipidemia, and infertility predicted the use of anti-obesity medications, while having Medicare coverage and being at risk of sleep apnea were associated with lower odds of usage.
ENDOCRINE PRACTICE
(2021)
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Clinical Neurology
Sofie Jacobs, Emilie Mylemans, Marijke Ysebaert, Eline Vermeiren, Ann De Guchtenaere, Hilde Heuten, Luc Bruyndonckx, Benedicte Y. De Winter, Kim Van Hoorenbeeck, Stijn L. Verhulst, Annelies Van Eyck
Summary: This study investigated the effect of weight loss on endothelial function and OSA in obese children, finding that weight loss significantly improved endothelial function. However, even after weight loss, the improvement in endothelial function was less pronounced in patients with OSA.
Letter
Medicine, General & Internal
Victor Jose Simon Frapolli, Jose Antonio Lopez Medina, Francisco Jose Tinahones Madueno
Article
Medicine, Research & Experimental
Cristina Ma Diaz-Perdigones, Araceli Munoz-Garach, Maria Dolores Alvarez-Bermudez, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that patients with early intolerance to metformin had higher levels of Subdoligranulum in the gut microbiome, while Veillonella and Serratia were higher in the non-tolerant group. The tolerant group showed enrichment of Megamonas, Megamonas rupellensis, and Phascolarctobacterium spp, with lower levels of Ruminococcus gnavus in the longitudinal analysis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Maria Molina-Vega, Maria J. Picon-Cesar, Carolina Gutierrez-Repiso, Andrea Fernandez-Valero, Fuensanta Lima-Rubio, Stella Gonzalez-Romero, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: In women with gestational diabetes mellitus, treatment with metformin led to lower postprandial glycemia and less weight gain compared to treatment with insulin. There were also changes in the composition of gut microbiota, with a decrease in Firmicutes and Peptostreptococcaceae abundance and an increase in Proteobacteria and Enterobacteriaceae abundance in the metformin group. Predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis were more prevalent in the metformin group. Further studies are needed to understand how these changes impact metabolic control during and after pregnancy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Carolina Lopez-Cano, Andreea Ciudin, Enric Sanchez, Francisco J. Tinahones, Ferran Barbe, Mireia Dalmases, Marta Garcia-Ramirez, Alfonso Soto, Anna Michela Gaeta, Silvia Pellitero, Raquel Marti, Cristina Hernandez, Rafael Simo, Albert Lecube
Summary: Liraglutide improves forced vital capacity and decreases serum SP-D levels in type 2 diabetes patients, suggesting a positive effect on alveolar-capillary function.
Article
Medicine, General & Internal
Andrea G. Izquierdo, Marcos C. Carreira, Hatim Boughanem, Jose M. Moreno-Navarrete, Carolina F. Nicoletti, Paula Oliver, Daniel Luis, Carla B. Nonino, Maria P. Portillo, Miguel A. Martinez-Olmos, Jose M. Fernandez-Real, Francisco J. Tinahones, J. Alfredo Martinez, Manuel Macias-Gonzalez, Felipe F. Casanueva, Ana B. Crujeiras
Summary: This study evaluated the methylation levels of the ACE2 gene in adipose tissue and leukocytes in obesity and after weight loss therapy. It was found that obesity was associated with higher ACE2 methylation levels in visceral adipose tissue and leukocytes, which could be reversed by weight loss therapy. These findings suggest a potential link between obesity-related ACE2 methylation and COVID-19 pathogenesis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Cesar Fernandez-Lazaro, Estefania Toledo, Pilar Buil-Cosiales, Jordi Salas-Salvado, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Emilio Ros, Clotilde Vazquez, Lidia Daimiel, Beatriz SanJulian, Jesus F. Garcia-Gavilan, Jose Sorli, Olga Castaner, M. Angeles Zulet, Lucas Tojal-Sierra, Napoleon Perez-Farinos, Alejandro Oncina-Canovas, Manuel Monino, Antonio Garcia-Rios, Emilio Sacanella, Rosa M. Bernal-Lopez, Jose Manuel Santos-Lozano, Zenaida Vazquez-Ruiz, Jananee Muralidharan, Carolina Ortega-Azorin, Alberto Goday, Cristina Razquin, Leire Goicolea-Guemez, Miguel Ruiz-Canela, Nerea Becerra-Tomas, Helmut Schroder, Miguel A. Martinez Gonzalez
Summary: The study indicated that participants with high baseline perceived self-efficacy, higher fiber intake, multiple chronic conditions (especially depression) were more likely to successfully comply with an energy-reduced Mediterranean diet. Tailored interventions focusing on these factors may lead to greater dietary changes and nutritional improvements.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Almudena Carneiro-Barrera, Francisco J. Amaro-Gahete, Lucas Jurado-Fasoli, German Saez-Roca, Carlos Martin-Carrasco, Francisco J. Tinahones, Jonatan R. Ruiz
Summary: An eight-week interdisciplinary weight loss and lifestyle intervention resulted in significant improvements in dietary behavior, including adherence to the Mediterranean diet, in overweight/obese men with moderate-to-severe OSA.
Article
Nutrition & Dietetics
Isabel Cornejo-Pareja, Isabel M. Vegas-Aguilar, Henry Lukaski, Antonio Talluri, Diego Bellido-Guerrero, Francisco J. Tinahones, Jose Manuel Garcia-Almeida
Summary: This study found that hydration status is an important predictor of survival prognosis in COVID-19 patients, with higher hydration levels associated with higher mortality. Compared to traditional measurements, using a 50kHz phase-sensitive bioelectrical impedance measurement for hydration assessment can provide a more sensitive and specific prognostic test.
Article
Medicine, General & Internal
Hanieh Motahari-Rad, Alba Subiri, Rocio Soler, Luis Ocana, Juan Alcaide, Jorge Rodriguez-Capitan, Veronica Buil, Hamid el Azzouzi, Almudena Ortega-Gomez, Rosa Bernal-Lopez, Maria Insenser, Francisco J. Tinahones, Mora Murri
Summary: This study analyzed the impact of sex, obesity, and their interactions on the gene expression of two lipid flippases in visceral adipose tissue (VAT). The results showed that obesity had a significant influence on the gene expression of these flippases, with a stronger effect in men for one of the flippases. The study also found associations between these flippases and microRNAs, which were also affected by sex.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Cristina Bouzas, Maria del Mar Bibiloni, Silvia Garcia, David Mateos, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Blanca Riquelme-Gallego, Vicente Martin-Sanchez, Xavier Pinto, Jose J. Gaforio, Pilar Matia, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emilio Ros, Elena Pascual-Roquet-Jalmar, Nancy Babio, Inmaculada Gonzalez-Monge, Olga Castaner, Itziar Abete, Carolina Sorto-Sanchez, Juan Carlos Benavente-Marin, Laura Torres-Collado, Marian Martin, Antonio Garcia-Rios, Sara Castro-Barquero, Jose C. Fernandez-Garcia, Jose Manuel Santos-Lozano, Cesar I. Fernandez-Lazaro, Albert Salas-Huetos, Patricia Guillem-Saiz, Maria Dolores Zomeno, Maria angeles Zulet, Amaia Goikoetxea-Bahon, Alfredo Gea, Stephanie K. Nishi, Helmut Schroeder, Josep A. Tur
Summary: In a large cardiovascular prevention trial, older adults with metabolic syndrome who had more ambitious desired weight loss goals experienced improvements in diet, cardiovascular health, and perceived physical health during the first year of a healthy lifestyle intervention program. Weight dissatisfaction should be taken into consideration by healthcare professionals.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yuan-Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco Jose Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Summary: This study compared the effects of bexagliflozin tablets and glimepiride on the treatment of patients with type 2 diabetes. It was found that bexagliflozin tablets were noninferior to glimepiride in lowering HbA1c levels, and were superior in reducing body mass and systolic blood pressure. Additionally, bexagliflozin tablets were associated with fewer hypoglycemic events and had a favorable effect on estimated glomerular filtration rate (eGFR).
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jose Carlos Fernandez-Garcia, Rocio Barrios-Rodriguez, Maite Asenjo-Plaza, Bruno Ramos-Molina, Maria Molina-Vega, Antonio Guzman-Guzman, Luis Moreno-Leon, Elena M. Yubero-Serrano, Francisca Rius-Diaz, Sergio Valdes, Miguel Angel Martinez-Gonzalez, Jose Juan Jimenez-Moleon, Francisco J. Tinahones
Summary: Among men with obesity and low testosterone concentrations, the combination of metformin plus testosterone, metformin only, and testosterone only, compared to placebo, reduced insulin resistance with no evidence of additive benefit.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Nutrition & Dietetics
Hatim Boughanem, Pallavi Kompella, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Gene expression can be regulated by epigenomic modifications such as DNA methylation, histone modification, and chromosome remodeling. Vitamins, as natural bioactive compounds, have been found to modify epigenetic patterns and potentially impact the risk of cancer, including colorectal cancer (CRC). This review examines the relationship between vitamins and CRC risk through epidemiological and observational studies and discusses the potential of using vitamins as epigenetic modifiers for CRC treatment. Although more studies with better designs are needed, understanding the molecular mechanisms of vitamin-mediated epigenetic regulation can help identify effective therapeutic targets for CRC prevention and treatment.
Article
Cardiac & Cardiovascular Systems
Maria Rubin-Garcia, Facundo Vitelli-Storelli, Laura Alvarez-Alvarez, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Alvaro Hernaez, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Luis Serra-Majem, Naomi Cano-Ibanez, Josep A. Tur, Alba Marcos-Delgado, Anna Tresserra-Rimbau, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Zenaida Vazquez-Ruiz, Nancy Babio, Rocio Barragan, Olga Castaner-Nino, Cristina Razquin, Lucas Tojal-Sierra, Enrique Gomez-Gracia, Sandra Gonzalez-Palacios, Marga Morey, Antonio Garcia-Rios, Sara Castro-Barquero, Maria Rosa Bernal-Lopez, Jose Manuel Santos-Lozano, Miguel Ruiz-Canela, Antoni Castro-Salomo, Eva Cristina Pascual-Castello, Veronica Moldon, Vanessa Bullon-Vela, Carolina Sorto-Sanchez, Juan Carlos Cenoz-Osinaga, Liliana Gutierrez, Maira Mengual, Rosa Maria Lamuela-Raventos, Vicente Martin-Sanchez
Summary: This study found an inverse association between the intake of certain subclasses of polyphenols and serum uric acid levels and hyperuricemia in individuals with metabolic syndrome. Further research is needed to confirm these findings.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)