Article
Medicine, General & Internal
Sandeep Kumar, Wahid Ali, Sridhar Mishra, Akshyaya Pradhan, Rishi Sethi, Rashmi Kushwaha, Uma Shankar Singh, Marco Alfonso Perrone
Summary: The study revealed that sLOX-1 can serve as a biomarker for stable CAD and ACS, with potential in predicting the risk of future recurrence of coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Katharine A. Kott, Elijah Genetzakis, Michael P. Gray, Peter Hansen, Helen M. Mcguire, Jean Y. Yang, Stuart M. Grieve, Stephen T. Vernon, Gemma A. Figtree
Summary: Researchers found that serum sLOX-1 is associated with the severity and incidence of CAD, especially in the population without standard modifiable cardiovascular risk factors (SMuRFs), suggesting that sLOX-1 can be a useful biomarker for risk prediction.
Article
Surgery
Halit Eren Taskin, Ahmet Kocael, Pinar Kocael, Kagan Zengin, Muzaffer Al, Volkan Sozer, J. N. Buchwald, T. W. McGlennon, Hafize Uzun
Summary: The study found that weight loss induced by sleeve gastrectomy (SG) can improve the cardiovascular conditions of patients with morbid obesity. After 12 months of SG, metabolic and inflammatory biomarkers significantly decreased and approached the levels of the control group. Baseline albumin level as well as the reduction in oxLDL and cholesterol retention fraction (CRF) were correlated with the reduction in sLOX-1.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Reham A. Hussein, Omar F. Abdul-Rasheed, Mouayed Basheer
Summary: The study found that sLOX-1 levels were significantly elevated in patients with acute coronary syndrome, and the ratio of sLOX-1 and oxidative LDL showed high accuracy in diagnosing myocardial infarction.
ACTA BIOCHIMICA POLONICA
(2022)
Article
Medicine, Legal
Shojiro Takasu, Sari Matsumoto, Yuko Kanto, Suzuka Shimmura, Kyoko Iwadate, Kimiharu Iwadate
Summary: The study found that LOX-1, the endothelial receptor for oxidized LDL, is released into the blood as soluble LOX-1 (sLOX-1) and is associated with ischemic heart disease (IHD), cerebrovascular diseases (CVDs), obesity, and diabetes. The results suggest that measuring sLOX-1 levels in postmortem pericardial fluid can be used for the diagnosis of IHD and CVD.
FORENSIC SCIENCE INTERNATIONAL
(2023)
Article
Neurosciences
Anxin Wang, Xue Tian, Jie Xu, Hao Li, Qin Xu, Pan Chen, Xia Meng, Yongjun Wang
Summary: This study found a positive association between sLOX-1 and the risk of recurrent stroke, and the addition of sLOX-1 to conventional risk models improved the predictive value for recurrent stroke. Furthermore, the association between higher sLOX-1 and recurrent stroke was more pronounced in patients with a history of stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luscher
Summary: LOX-1, as a scavenger receptor, plays a crucial role in the development of atherosclerosis, with implications in various cell types, making it a promising diagnostic and therapeutic target for certain cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Tatsuya Sawamura, Chu-Huang Chen, Simon Kraler, Daria Vdovenko, Thomas F. Luescher
Summary: LOX-1, a scavenger receptor that promotes atherosclerotic plaque formation, plays a critical role in the development of cardiovascular diseases. Its expression in various cell types underscores its significance in disease progression, highlighting the potential for LOX-1 as a novel therapeutic target in CVDs prevention and treatment.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Can Li, Fenglin Liu, Xu Yang, Bao Guo, Guoyun Li, Jie Yin, Gaofei He, Caiting Yang, Ling Xu, Shuxuan Li, Hao Wu, Hai Liu, Yuanyuan Ruan, Jianxin Gu, Lan Wang
Summary: LOX-1 is upregulated in esophageal cancer tissues and associated with poor prognosis. Deletion of LOX-1 suppresses EC development by inducing autophagic cell death. Fucoidan binds with LOX-1 and mediates its proteasomal degradation, leading to autophagy-related cell death in EC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Sara E. Stinson, Anna E. Jonsson, Mette K. Andersen, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Yun Huang, Evelina Stankevic, Helene Baek Juel, Lars aengquist, Thorkild I. A. Sorensen, Emily L. Ongstad, Ranjitha Gaddipati, Joseph Grimsby, Christopher J. Rhodes, Oluf Pedersen, Michael Christiansen, Jens-Christian Holm, Torben Hansen
Summary: This study found that sLOX-1 levels were elevated during and after puberty in children and adolescents with overweight/obesity, and were associated with inflammatory markers and worsened cardiometabolic risk profiles. sLOX-1 may serve as an early marker of cardiometabolic risk and inflammation in pediatric overweight/obesity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Kraler, Florian A. Wenzl, Georgios Georgiopoulos, Slayman Obeid, Luca Liberale, Arnold von Eckardstein, Olivier Muller, Francois Mach, Lorenz Raeber, Sylvain Losdat, Martin O. Schmiady, Konstantinos Stellos, Kimon Stamatelopoulos, Giovanni G. Camici, Annie Srdic, Francesco Paneni, Alexander Akhmedov, Thomas F. Luescher
Summary: sLOX-1 is associated with fatal events and plaque progression in patients with acute coronary syndromes (ACS). Increased sLOX-1 levels predict mortality risk and coronary plaque progression beyond traditional risk factors.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, Research & Experimental
Qian Zhang, Tao Xu, Na Bai, Fei Tan, Hongmei Zhao, Jie Liu
Summary: This study found that MMP2 expression was increased in peri-implantitis and was mediated by LOX-1, enhanced by JNK and ERK1/2 signaling pathways. The LOX-1/MMP2 signaling pathway may be a potential target for managing peri-implantitis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, General & Internal
Kaixuan Ren, Huayun Jiang, Tiantian Li, Chengqun Qian, Li Zhu, Tianle Wang
Summary: This study examines the correlation between soluble lectin-like oxidised low-density lipoprotein receptor-1 (sLOX-1) levels and culprit plaque characteristics based on high-resolution magnetic resonance vessel wall imaging (HR-MR-VWI), and its association with stroke recurrence. The results show that higher sLOX-1 levels are associated with more vulnerable plaques and increased risk of stroke recurrence, suggesting that sLOX-1 can be used as a supplementary indicator to predict recurrence in patients with symptomatic intracranial artery atherosclerosis.
Article
Food Science & Technology
Qing Li, Xiuping Liu, Xu Zhang, Yushi Du, Guanyu Chen, Panyin Xiang, Wenhua Ling, Dongliang Wang
Summary: Sustained inflammation promotes macrophage foam cell formation by promoting cholesterol influx and impairing cholesterol efflux. Lactucopicrin at physiologically reachable concentrations inhibits oxLDL-induced foam cell formation in inflammatory mouse macrophages. The mechanism involves reducing LOX-1 distribution in lipid rafts, which contributes to its atheroprotective effect.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Layal El-Hajjar, Judy Hindieh, Rana Andraos, Marwan El-Sabban, Jalil Daher
Summary: Cardiovascular disease caused by atherosclerosis is a major cause of death worldwide. This study explores the role of oxidized LDL and the LOX-1 scavenger receptor in endothelial dysfunction and inflammation, providing insight into the pathways involved in atherosclerosis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
