Journal
NUTRITIONAL NEUROSCIENCE
Volume 18, Issue 6, Pages 265-274Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/1476830514Y.0000000125
Keywords
Choline; Toxicity; Global brain ischemia; Lipid peroxidation; Membrane; Neurodegeneration; Neuroprotection; Rat
Categories
Funding
- CNPq
- FAPESP
- CAPES
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Choline - now recognized as an essential nutrient - is the most common polar group found in the outer leaflet of the plasma membrane bilayer. Brain ischemia-reperfusion causes lipid peroxidation triggering multiple cell death pathways involving necrosis and apoptosis. Membrane breakdown is, therefore, a major pathophysiologic event in brain ischemia. The ability to achieve membrane repair is a critical step for survival of ischemic neurons following reperfusion injury. The availability of choline is a rate-limiting factor in phospholipid synthesis and, therefore, may be important for timely membrane repair and cell survival. This work aimed at verifying the effects of 7-day oral administration with different doses of choline on survival of CA1 hippocampal neurons following transient global forebrain ischemia in rats. The administration of 400 mg/kg/day divided into two daily doses for 7 consecutive days significantly improved CA1 pyramidal cell survival, indicating that the local availability of this essential nutrient may limit postischemic neuronal survival.
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