Article
Gastroenterology & Hepatology
Laura Conti, Marina Borro, Christian Milani, Maurizio Simmaco, Gianluca Esposito, Giulia Canali, Emanuela Pilozzi, Marco Ventura, Bruno Annibale, Edith Lahner
Summary: Patients with corpus atrophic gastritis show reduced abundance and complexity in their gastric bacterial microbiota, characterized by higher colonization of Firmicutes, especially Streptococcus, associated with severe atrophy/metaplasia stages and higher risk of gastric cancer.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Oncology
Hourin Cho, Masayoshi Yamada, Shigeki Sekine, Noriko Tanabe, Mineko Ushiama, Makoto Hirata, Gakuto Ogawa, Masahiro Gotoh, Teruhiko Yoshida, Takaki Yoshikawa, Yutaka Saito, Aya Kuchiba, Ichiro Oda, Kokichi Sugano
Summary: This study investigated the incidence risk and clinicopathological features of gastric neoplasms in Lynch syndrome (LS) patients, finding that LS patients with atrophic gastritis are at higher risk of developing gastric tumors, often presenting with multiple tumors. Endoscopic surveillance for gastric cancer is recommended for LS patients, especially those with atrophic gastritis.
Article
Oncology
Ombretta Repetto, Valli De Re, Paolo Giuffrida, Marco Vincenzo Lenti, Raffaella Magris, Marino Venerito, Agostino Steffan, Antonio Di Sabatino, Renato Cannizzaro
Summary: This study identified a proteomics signature of AAG, with many differential proteins shared by GC, potentially involved in the progression of AAG to GC.
Article
Oncology
Sara Massironi, Camilla Gallo, Alessandra Elvevi, Marta Stegagnini, Lorenzo Andrea Coltro, Pietro Invernizzi
Summary: The incidence and prevalence of type I gastric neuroendocrine neoplasms (gNENs) in patients with autoimmune gastritis (AIG) have been increasing. Gastrin, a potential marker for early diagnosis, has low diagnostic accuracy, highlighting the need for effective strategies for early detection and treatment.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Microbiology
Giulia Pivetta, Ludovica Dottori, Federico Fontana, Sophia Cingolani, Irene Ligato, Emanuele Dilaghi, Christian Milani, Marco Ventura, Marina Borro, Gianluca Esposito, Bruno Annibale, Edith Lahner
Summary: This study aimed to assess gender differences in gastric bacterial microbiota between subjects with healthy stomachs and those with autoimmune atrophic gastritis. Results showed that women with healthy stomachs had a higher gastric bacterial abundance and less microbial diversity compared to men. Autoimmune atrophic gastritis seems to reset gender differences in gastric bacterial abundance and reduce biodiversity in males.
Article
Gastroenterology & Hepatology
Angelo Zullo, Bastianello Germana, Ermenegildo Galliani, Andrea Iori, Giovanni de Pretis, Guido Manfredi, Elisabetta Buscarini, Mario Ciuffi, Orazio Ignomirelli, Fabio Farinati, Edoardo Savarino, Paolo Pallini, Luisa Milan, Rita Conigliaro, Giuseppe Grande, Renato Cannizzaro, Stefania Maiero, Antonio Pisani, Stefania Marangi, Raffaele Manta, Olivia Morelli, Sergio Peralta, Alessia La Mantia, Matteo Rossano Buonocore, Kareem Khalal, Cesare Hassan, Fabio Monica
Summary: This study evaluated the accuracy of EndoFaster(R) device in ruling out gastric mucosal atrophy and found that it had a high negative predictive value in excluding atrophic gastritis, reducing the need for gastric biopsies.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Endocrinology & Metabolism
Wei Xu, Tianxiao Jiang, Kanger Shen, Dongxu Zhao, Man Zhang, Wenxin Zhu, Yunfei Liu, Chunfang Xu
Summary: In this study, pathogenic genes associated with chronic atrophic gastritis (CAG) were identified through comprehensive analysis of bulk transcriptome and single-cell transcriptome data. Among these genes, GADD45B was determined to be the most significant oncogene in CAG carcinogenesis, correlated with prognosis, immune infiltration, and metabolic pathways in gastric cancer (GC) patients. Furthermore, the CD99 and CDH signaling pathways were found to have a significant impact on the microenvironment of gastric tissue during the development of CAG, and key metabolic pathways involved in GC progression were identified.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Kai Zhao, Yu Zhang, Suhong Xia, Lina Feng, Wangdong Zhou, Mingyu Zhang, Ruonan Dong, Dean Tian, Mei Liu, Jiazhi Liao
Summary: EBV infection is significantly associated with atrophic gastritis, particularly in H. pylori-negative patients. EBV infection also influences gastric function by decreasing the PG I/PG II ratio. Co-infection of EBV and H. pylori does not increase the risk of atrophic gastritis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Multidisciplinary Sciences
Liangjun Yang, Xinying Liu, Jiajie Zhu, Xi Zhang, Ya Li, Jiabing Chen, Haiyan Liu
Summary: Chronic gastritis is a persistent inflammation of the gastric mucosa that causes discomfort to patients. Traditional Chinese medicine has been widely used to treat this condition due to its precise efficacy, minimal side effects, and holistic approach. Clinical studies have confirmed its effectiveness, although the underlying mechanisms are not fully understood. In this review, we summarize the clinical research and mechanisms of traditional Chinese medicine for the treatment of chronic gastritis.
Article
Biochemistry & Molecular Biology
Tianyi Dong, Xiang Lan, Bingbing Fan, Shouyin Jia, Fengyan Liu, Qiang Feng, Yi Sun, Ning Zhong, Shili Liu
Summary: Bacterial biomarkers were found to distinguish patients with atrophic gastritis from those with non-atrophic gastritis. The composition analysis showed an increase in oral pathogens in atrophic gastritis patients, suggesting a potential trigger for exacerbation of gastritis. These differentially expressed bacteria were also used as diagnostic biomarkers with an accuracy of 90%.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Gastroenterology & Hepatology
Waku Hatta, Tomoyuki Koike, Sho Asonuma, Hideki Okata, Kaname Uno, Tomoyuki Oikawa, Wataru Iwai, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Motoki Ohyauchi, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Kazuaki Norita, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune, Tohoku G I Study Grp
Summary: This study found that smoking history and severe atrophic gastritis were risk factors for synchronous gastric cancers in patients who underwent ESD for early gastric cancers.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Malgorzata Osmola, Caroline Hemont, Nicolas Chapelle, Marie-Anne Vibet, David Tougeron, Driffa Moussata, Dominique Lamarque, Edith Bigot-Corbel, Damien Masson, Justine Blin, Maxime Leroy, Regis Josien, Jean-Francois Mosnier, Jerome Martin, Tamara Matysiak-Budnik
Summary: Despite the global decrease in gastric cancer incidence, there has been an increase in recent years among young patients, particularly females. The cause of this new type of gastric cancer is still unknown, but autoimmunity may play a role. A study was conducted to analyze the prevalence of several autoantibodies in patients with chronic atrophic gastritis (CAG) compared to control patients. The results showed that ANA positivity was significantly higher in autoimmune gastritis patients (AIG) compared to non-autoimmune gastritis patients (NAIG) and control patients, while APCA and AIFA positivity were confirmed in AIG. Overall, the study did not support an overrepresentation of common autoantibodies in CAG patients.
Article
Medicine, General & Internal
Xue-Mei Lin, Li Wang, Chun-Hui Xi, Jun Wang, Xian-Fei Wang, Qiong Wang, Cong Yuan
Summary: Atrophic gastritis can lead to mucosa thinning, but detailed metrological evidence is lacking. This study compared the morphological features of full-thickness gastric mucosa in the antrum and corpus and evaluated their diagnostic performance for atrophy. The results showed that the thickness of the mucosal layer in the corpus was positively correlated with the degree of atrophy, while the length of foveolar and glandular and total mucosal thickness were negatively correlated. The diagnostic performance of mucosal thickness for atrophy was limited, especially in the antrum.
Article
Gastroenterology & Hepatology
Laura Conti, Gloria Galli, Chiara Ligato, Marilia Carabotti, Bruno Annibale, Edith Lahner
Summary: The aim of this study was to assess the frequency of autoimmune atrophic gastritis (AAG) and coeliac disease (CD) association and compare the clinical, biochemical, and histological features of adults affected by both diseases. The results showed that the association between AAG and CD is rare, with a prevalence of 2% in AAG patients with CD. Adults with both AAG and CD were younger and had a higher prevalence of normocytic anaemia compared to those with AAG only.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Medicine, General & Internal
Chuyan Chen, Yi Yang, Peng Li, Haiyi Hu
Summary: This study systematically analyzed the incidence rate of gastric cancer, low-grade dysplasia, and type-1 gastric neuroendocrine tumor development in adults with autoimmune metaplastic atrophic gastritis (AMAG). Thirteen studies were included and the meta-analysis showed a relative risk of 11.05 for gastric cancer development in AMAG patients. The study emphasizes the potential for malignant transformation of precancerous lesions and the importance of careful esophagogastroduodenoscopy screening.
JOURNAL OF CLINICAL MEDICINE
(2023)
