Review
Cell Biology
Suqi Wu, Ketong Liu, Bingyan Zhou, Suwen Wu
Summary: Placenta, as a medium connecting pregnant women, environment, and fetus, plays a crucial role in regulating gene expression and maintaining cellular homeostasis through powerful and delicate epigenetic processes. N6-methyladenosine (m(6)A), the most prevalent RNA modification, shows dynamic reversibility and sensitivity to environmental stimuli, suggesting its significance in placental development and maternal-fetal crosstalk. Disturbance in proper m(6)A modifications due to environmental factors can lead to abnormal placentation, compromised function, and potential consequences of gestational diseases, fetal growth, and adult disease susceptibility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Erica Silvestris, Easter Anna Petracca, Michele Mongelli, Francesca Arezzo, Vera Loizzi, Maria Gaetani, Pierpaolo Nicoli, Gianluca Raffaello Damiani, Gennaro Cormio
Summary: Oocyte donation has become a preferred practice for infertile women wishing for motherhood, although it is associated with risks and complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Davell Carter, Marina Better, Saed Abbasi, Fareeha Zulfiqar, Rachel Shapiro, Laura M. Ensign
Summary: Conception, pregnancy, and childbirth are complex processes that have significant impact on both the mother and fetus. However, there is a lack of safe and effective treatment options in women's health and pregnancy. The physiological changes during menstrual cycle and pregnancy make drug administration and delivery more complicated, and overcoming physiological barriers is also challenging. Nanomedicine offers a unique opportunity to improve safety and minimize side effects by targeting drug delivery to the reproductive tract and other relevant organs in the mother and fetus, and has the potential to improve the management and treatment of infertility, obstetric complications, and fetal conditions.
Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Endocrinology & Metabolism
Daniela Mennickent, Andres Rodriguez, Ma. Cecilia Opazo, Claudia A. Riedel, Erica Castro, Alma Eriz-Salinas, Javiera Appel-Rubio, Claudio Aguayo, Alicia E. Damiano, Enrique Guzman-Gutierrez, Juan Araya
Summary: This study aims to explore the application of machine learning in obstetrics and gynecology, and finds that machine learning has great potential in predicting and managing pregnancy diseases and complications. The use of machine learning in this field has increased significantly in the past few years.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Louis J. Muglia, Katrien Benhalima, Stephen Tong, Susan Ozanne
Summary: This article explores the importance of improving pregnancy health for the lifelong well-being of the mother and offspring. It highlights the immediate and long-term impacts of maternal environmental factors on fetal development and maternal cardiometabolic health. Using 'omics technologies across different platforms, research on preterm birth, metabolic influences, maternal disorders, and their effects on pregnancy outcomes and child health is expected to provide new insights and preventative strategies.
Article
Neurosciences
Owen R. Vaughan, Fredrick J. Rosario, Jeannie Chan, Laura A. Cox, Veronique Ferchaud-Roucher, Karin A. Zemski-Berry, Jane E. B. Reusch, Amy C. Keller, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnant women can lead to cardiac dysfunction in the fetus and increase the risk of cardiovascular disease for their offspring. This research shows that maternal obesity induces hypertrophy in the fetal heart of mice and alters the expression of genes related to nutrient metabolism. Maternal obesity also affects the metabolism of carbohydrates and lipids in adult offspring. The results suggest that excessive nutrition during pregnancy may contribute to increased cardiovascular disease risk in children of obese mothers.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Pharmacology & Pharmacy
Ting Wu, Kaiyu Zhou, Yimin Hua, Wen Zhang, Yifei Li
Summary: The developmental origins of health and disease (DOHaD) hypothesis suggests that early-life environmental exposures can permanently affect an individual's health and shape their growth, structure, and metabolism. Recent studies have found that prenatal exposure to drugs increases the risk of adult-onset cardiovascular diseases. Observational and animal studies have demonstrated the association between prenatal drug exposure and programmed cardiovascular disease in offspring. The molecular mechanisms underlying these effects, which appear to involve metabolism dysregulation, are still being explored.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Anesthesiology
J. R. Dick, R. Wimalasundera, R. Nandi
Summary: Advances in early diagnosis, imaging, and surgical techniques have led to significant growth in fetal surgery over the past three decades. Anesthesia, particularly high-risk anesthesia for both the mother and fetus, is crucial in these procedures. Clear communication and collaboration among team members are essential for successful outcomes for patients, mothers, and fetuses.
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jerad Dumolt, Theresa L. Powell, Thomas Jansson, Fredrick J. Rosario
Summary: Infants born to obese mothers have a higher risk of childhood obesity and insulin resistance. Lower levels of maternal adiponectin, a hormone associated with placental nutrient transport and fetal overgrowth, contribute to these risks. Previous research showed that supplementing adiponectin in obese mice during pregnancy prevented obesity and metabolic dysfunction in their offspring. This study further demonstrates the importance of maternal adiponectin levels in the development of metabolic diseases in offspring and suggests that improving these levels could prevent long-term metabolic dysfunction in children of obese mothers.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of adverse maternal and fetal outcomes caused by maternal diabetes are increasing. Many researchers have investigated natural treatment methods due to the problems associated with hypoglycemic drugs. Polyphenols have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy through various mechanisms. Diets rich in polyphenols are beneficial to pregnant women with diabetes. However, further research is needed to better understand the complex interactions between polyphenols and maternal diabetes.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of maternal and fetal adverse outcomes caused by maternal diabetes are increasing. Polyphenols have been shown to have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy. However, further research is needed to fully understand the complex interactions between polyphenols and maternal diabetes.
Article
Psychiatry
Karolina Lutkiewicz, Mariola Bidzan
Summary: This study aimed to evaluate maternal adult attachment and maternal-fetal attachment in relation to romantic relationship quality among mothers of preterm born children. The results showed that a secure attachment style is associated with a higher intensity of maternal-fetal attachment and a higher quality of the romantic relationship. Furthermore, the secure attachment style was found to be a protective factor in coping with stress and depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Hua Zen Ling, Gavin P. Guy, Alessandra Bisquera, Kypros H. Nicolaides, Nikos A. Kametas
Summary: This study aimed to evaluate the trends in maternal cardiac function, fetal growth, and oxygenation with advancing gestational age in a routine obstetrical population and all ranges of birthweight percentiles. The results showed that there were differences in cardiac adaptation, fetal growth pattern, and oxygenation between different birthweight percentile groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
