Journal
TALANTA
Volume 144, Issue -, Pages 252-257Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2015.06.020
Keywords
Self-assembly; Paracetamol; Multi-walled carbon nanotubes; Chitosan; Copper
Categories
Funding
- National Natural Science Foundation of China [21275124, 21305123]
- National Natural Science Foundation of Jiangsu Province [BK2012247]
- Foundation of Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province [AE201162]
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An electrochemical sensor for paracetamol based on multi-walled carbon nanotubes and chitosan-copper complex (MWCNTs/CTS-Cu) was fabricated by self-assembly technique. The MWCNTs/CTS-Cu modified GCE showed an excellent electrocatalytic activity for the oxidation of paracetamol, and accelerated electron transfer between the electrode and paracetamol. Under optimal experimental conditions, the differential pulse peak current was linear with the concentration of paracetamol in the range of 0.1-200 mu mol L-1 with a detection limit of 0.024 mu mol L-1. The sensitivity was found to be 0.603 A/mol L-1. The proposed sensor also showed a high selectivity for paracetamol in the presence of ascorbic acid and dopamine. Moreover, the proposed electrode revealed good reproducibility and stability. The proposed method was successfully applied for the determination of paracetamol in tablet and human serum samples. (C) 2015 Elsevier B.V. All rights reserved.
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