Article
Endocrinology & Metabolism
Jiandong Zhou, Sharen Lee, Xuejin Liu, Danish Iltaf Satti, Teddy Tai Loy Lee, Oscar Hou In Chou, Carlin Chang, Leonardo Roever, Wing Tak Wong, Abraham Ka Chung Wai, Tong Liu, Qingpeng Zhang, Gary Tse
Summary: This study suggests that in elderly patients in China, the use of edoxaban is associated with lower risks of new onset hip fractures, medically attended falls, and mortality compared to warfarin.
Article
Cardiac & Cardiovascular Systems
Malik Elharram, Michelle Samuel, Ahmed AlTurki, Michael Quon, Hassan Behlouli, Amal Bessissow, Louise Pilote
Summary: This study aimed to investigate the association between oral anticoagulation (OAC) use and thromboembolic events and major bleeding in patients with new postoperative atrial fibrillation (POAF) after noncardiac surgery. The results showed that OAC was not associated with a reduction in long-term thromboembolic events in these patients, but it did increase the risk for major bleeding. Future prospective clinical studies are needed to better understand the efficacy and safety of anticoagulation therapy in the setting of POAF after noncardiac surgery.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vilert A. Loving, Brian S. Johnston, Denise H. Reddy, Leslie A. Welk, Hannah A. Lawther, Shayna C. Klein, Caroline M. Cranford, R. Christopher Reed, Pooja Rangan, Michael F. Morris
Summary: The study aimed to determine the hematoma risk after core-needle breast biopsy in patients receiving antithrombotic medication and to stratify the risk by antithrombotic type. The results showed that clinically significant hematomas were uncommon, suggesting that withholding antithrombotic medications before biopsy may be unnecessary.
Article
Medicine, General & Internal
Carlo Rostagno, Gaia Rubbieri, Mattia Zeppa, Alessandro Cartei, Alice Ceccofiglio, Giulio Maria Mannarino, Gualtiero Palareti, Elvira Grandone
Summary: This study aimed to investigate the perioperative management and long-term prognosis of elderly patients undergoing urgent hip surgery while receiving antithrombotic treatment. The study found that anticoagulants may delay surgery, but a delay of more than 48 hours does not have a significant impact on prognosis. Patients receiving warfarin had a lower one-year survival rate, potentially due to their higher risk profile at the time of trauma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Jun Chen, Lingchun Lyu, Jiayi Shen, Chunlai Zeng, Cheng Chen, Tiemin Wei
Summary: The study demonstrated that NOACs are associated with a lower risk of fractures compared to warfarin after more than 2 years of anticoagulation. Rivaroxaban users have a lower risk of fractures in AF patients compared to warfarin users, but there is no evidence that apixaban, edoxaban, and dabigatran can reduce the risk of all fractures and hip fractures.
Review
Cardiac & Cardiovascular Systems
Huei-Kai Huang, Carol Chiung-Hui Peng, Shu-Man Lin, Kashif M. Munir, Rachel Huai-En Chang, Brian Bo-Chang Wu, Peter Pin-Sung Liu, Jin-Yi Hsu, Ching-Hui Loh, Yu-Kang Tu
Summary: Compared with warfarin, NOACs are associated with lower risks of bone fracture, particularly in hip fractures. Dabigatran, rivaroxaban, and apixaban were found to be significantly associated with lower fracture risks. The findings from randomized controlled trials and real-world cohort studies were consistent, supporting the conclusion of the study.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Francesca Cerreta, Katarina Vucic, Andrea Laslop
Summary: The aging processes affect the body's response to medications and elderly patients are underrepresented in clinical trials. Evidence-based prescribing guidelines may result in inappropriate prescriptions, increasing the risk of drug interactions and adverse reactions. Clear information and proper consideration of older patients are necessary.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, N. C. Harvey, V. Gudnason, G. Sigurdsson, K. Siggeirsdottir, M. Lorentzon, E. Liu, L. Vandenput, W. D. Leslie, E. V. McCloskey
Summary: Recent fragility fractures are better captured with a 10-year fracture probability than 2- or 5-year probabilities. The study found that the recency of fractures affects subsequent fracture risk, with 10-year probability providing more accurate analysis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Respiratory System
Christer Janson, Karin Lisspers, Bjoern Staellberg, Gunnar Johansson, Florian S. Gutzwiller, Karen Mezzi, Linda Mindeholm, Bine Kjoeller Bjerregaard, Leif Jorgensen, Kjell Larsson
Summary: Analysis of long-term medical record data on COPD patients and matched controls revealed that patients with COPD have a higher risk of bone fractures and osteoporosis, with high-dose ICS use further increasing this risk.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon Louise Cadogan, Emma Powell, Kevin Wing, Angel Yun Wong, Liam Smeeth, Charlotte Warren-Gash
Summary: Among patients with newly diagnosed atrial fibrillation, treatment with direct oral anticoagulants (DOACs) was associated with a reduced incidence of dementia and mild cognitive impairment, with a 16% reduction in dementia diagnosis and a 26% reduction in incident MCI compared to treatment with Vitamin K antagonists (VKAs).
Article
Orthopedics
Ashley E. Levack, Harold G. Moore, Stephen R. Stephan, Sally Jo, Ian G. Schroeder, John M. Garlich, Aidan Hadad, Milton T. M. Little, Anna N. Miller, Stephen Lyman, Joseph M. Lane
Summary: This study found that warfarin has a negative effect on blood transfusion and postoperative complications in low-energy hip fracture patients. Patients on warfarin require more blood transfusions and have a higher incidence of postoperative complications compared to non-anticoagulated patients.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Multidisciplinary Sciences
Omolade Adeniyi, LaTimberly Washington, Christina J. Glenn, Sarah G. Franklin, Anniecia Scott, Maung Aung, Soumya J. Niranjan, Pauline E. Jolly
Summary: The study revealed that most patients use herbal medications in addition to prescription drugs, believing that herbs can control their conditions, yet they do not believe in simultaneous use of both. The majority of patients do not disclose their herbal medicine use to healthcare providers. In the focus group discussions, patients highly valued the effectiveness of herbal medicines, and highlighted the role of family elders and religiosity in herbal use.
Article
Endocrinology & Metabolism
Yining Wang, Liming Yu, Zhiqiang Ye, Rui Lin, Antonia RuJia Sun, Lingna Liu, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Li Li, Yanzhi Liu
Summary: Through a systematic review and meta-analysis, it was found that there was no significant correlation between fracture risk and metformin application in type 2 diabetes mellitus patients. Further research is needed to make a definite conclusion due to the limited number of existing studies, providing clinical consensus with more evidence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Adina A. Iftimi, Clara L. Rodriguez-Bernal, Salvador Peiro, Santiago Bonanad, Andreu Ferrero-Gregori, Isabel Hurtado, Anibal Garcia-Sempere, Gabriel Sanfelix-Gimeno
Summary: This study found no clear association between the use of vitamin K antagonists (VKAs) and reducing cancer risk, compared to direct oral anticoagulants (DOACs), in a large cohort of atrial fibrillation patients. The results did not show a chemoprotective effect of VKA over a follow-up period of up to 5 years.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Cheng-Hsun Chuang, Shun-Fa Yang, Pei-Lun Liao, Jing-Yang Huang, Man-Yee Chan, Chao-Bin Yeh
Summary: The study demonstrated that the use of thiazide diuretics in hypertensive patients can reduce the risk of fractures, making it a better choice for those at heightened risk of fractures.
JOURNAL OF CLINICAL MEDICINE
(2022)
