Article
Oncology
Joseph DeMari, Monica Hagan Vetter, Shruthi Chandra, John L. Hays, Ritu Salani
Summary: The study aimed to investigate practice patterns for surveillance of primary ovarian cancer after complete response to therapy, and to identify the percentage of clinicians who follow the surveillance guidelines endorsed by the Society of Gynecologic Oncology. Results showed that 78% of patients complied with the guidelines, but patients with early-stage cancer and non-serous histologies were more likely to be non-compliant.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Aeran Seol, Ga Won Yim, Joo Yeon Chung, Se Ik Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong Sang Song
Summary: This study identified patients who would benefit from third and subsequent lines of chemotherapy in recurrent epithelial ovarian cancer (EOC). The findings suggest that these patients with serous or endometrioid histology, initial platinum sensitivity, and long treatment-free intervals from the previous chemotherapy regimen could be considered for palliative chemotherapy.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Aida Jlassi, Maroua Manai, Maram Morjen, Ghada Sahraoui, Monia Elasmi Allal, Ines ELBini-Dhouib, Lamia Naija, Lamia Charfi, Rim Rejaibi, Melika Ben Ahmed, Naziha Marrakchi, Najet Srairi-Abid, Amel Mezlini, Mohamed Manai, Karima Mrad, Raoudha Doghri
Summary: Immunotherapy targeting immune checkpoint regulators, such as VISTA, has shown promise as a new treatment option for certain cancers. This study investigated the role of VISTA in epithelial ovarian cancer (EOC) and its relationship with tumor-infiltrating lymphocytes (TILs) markers and prognosis. The expression of VISTA and TILs markers was evaluated in EOC tissue samples, and the association with clinicopathological variables and overall survival (OS) was analyzed. Results showed that VISTA expression was significantly associated with a high density of TILs, particularly CD8+ TILs, in immune cells (ICs). Furthermore, a subtype characterized by dual positive VISTA+/CD8+ was associated with prolonged OS in both tumor cells (TCs) and ICs. These findings suggest that VISTA could be a potential immunotherapeutic target in EOC.
Article
Reproductive Biology
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Tariq Masoodi, Padmanaban Annaiyappanaidu, Ismail A. Al-Badawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: Our study shows that the expression of CDK9 in Middle Eastern ethnicity ovarian cancer correlates with markers of advanced disease and serves as a prognostic marker. CDK9 overexpression also identifies a subset of patients with the highest likelihood of recurrence.
JOURNAL OF OVARIAN RESEARCH
(2021)
Review
Reproductive Biology
Shona Nag, Shyam Aggarwal, Amit Rauthan, Narayanankutty Warrier
Summary: Epithelial ovarian cancer is a highly lethal gynecological cancer, often diagnosed at an advanced stage. Cytoreductive surgery along with chemotherapy is the main treatment approach. In recent years, neo-adjuvant chemotherapy followed by interval surgery and maintenance therapy have gained importance. PARP inhibitors have shown promising results as maintenance therapy, especially for tumors with homologous recombination deficiency.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Laura M. Chambers, Emily L. Esakov Rhoades, Rashmi Bharti, Chad Braley, Surabhi Tewari, Lexie Trestan, Zahraa Alali, Defne Bayik, Justin D. Lathia, Naseer Sangwan, Peter Bazeley, Amy S. Joehlin-Price, Zeneng Wang, Sumita Dutta, Mohammed Dwidar, Adeline Hajjar, Philip P. Ahern, Jan Claesen, Peter Rose, Roberto Vargas, J. Mark Brown, Chad M. Michener, Ofer Reizes
Summary: This study investigated the impact of antibiotic treatment on the growth and cisplatin sensitivity of ovarian cancer. The findings suggest that antibiotic treatment may promote tumor growth and suppress cisplatin sensitivity. Antibiotic treatment led to reduced apoptosis, increased DNA damage repair, enhanced angiogenesis, and increased frequency of cisplatin-augmented cancer stem cells.
Review
Biochemistry & Molecular Biology
Fulvio Borella, Stefano Fucina, Luca Mangherini, Stefano Cosma, Andrea Roberto Carosso, Jessica Cusato, Paola Cassoni, Luca Bertero, Dionyssios Katsaros, Chiara Benedetto
Summary: Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women, and its treatment remains challenging with poor survival rates. While the role of hormone receptors (HRs) in EOC has been actively explored, the use of hormone therapy (HT) in treating these tumors is still not well-established. Available data mostly come from retrospective series and small early clinical trials, suggesting that HT may be beneficial in adjuvant therapy, maintenance therapy, or in cases of recurrent disease, particularly for certain subtypes of EOC.
Article
Biochemistry & Molecular Biology
Maritza P. Garrido, Allison N. Fredes, Lorena Lobos-Gonzalez, Manuel Valenzuela-Valderrama, Daniela B. Vera, Carmen Romero
Summary: Epithelial ovarian cancer is one of the deadliest gynaecological malignancies. Late diagnosis is frequent due to the absence of specific symptoms and the molecular complexity of the disease. Recently, anti-angiogenic therapy and PARP inhibitors have been introduced, which have shown to increase the survival of ovarian cancer patients. However, the identification of patients who benefit the most is still under investigation.
Article
Oncology
Szymon Piatek, Iwona Szymusik, Piotr Sobiczewski, Wojciech Michalski, Magdalena Kowalska, Mariusz Oltarzewski, Mariusz Bidzinski
Summary: This study aimed to evaluate the recurrence and birth rates among patients with non-epithelial ovarian cancer. A total of 146 patients who underwent fertility-sparing surgery for germ cell (GCT) and sex cord-stromal tumors (SCST) were included. The 5- and 10-year disease-free survival rates were 91% and 83%, respectively. After a 24-month follow-up, the recurrence rate was higher than the rate of childbearing, but after 2 years, the childbearing rates exceeded the rate of recurrence.
Article
Pharmacology & Pharmacy
N. Brandhonneur, Y. Boucaud, A. Verger, N. Dumait, Y. Molard, S. Cordier, G. Dollo
Summary: Poly (lactic-co-glycolic) acid nanoparticles loaded with inorganic molybdenum octahedral clusters were used for photodynamic therapy of ovarian cancer. Among the studied cluster compounds, CMIF-loaded nanoparticles showed higher internalization efficiency in A2780 ovarian cancer cell line and significant decrease in cellular viability following photo-activation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Nicole E. James, Morgan Woodman, Jennifer R. Ribeiro
Summary: EOC patients have low response rates to immunotherapies, but evidence suggests ovarian tumors are immunogenic and immune-related genomic profiles can serve as prognostic markers. Specific research areas that need to be addressed include developing immune-based prognostic signatures and driving advancements in this field.
Article
Reproductive Biology
Yi Hu, Kun Fu, Huining Liu, Qiongqiong He, Xiaoqin Qiu, Wenqing Yang, Yu Zhang
Summary: This study aimed to investigate whether ovarian seromucinous carcinoma truly represented a distinct category of ovarian tumors or an analogue of ovarian endometrioid carcinoma. Through the analysis of clinicopathological features and prognosis of 12 patients, it was found that ovarian seromucinous carcinoma and ovarian endometrioid carcinoma had significant differences in clinical characteristics and prognosis, indicating that direct classification of ovarian seromucinous carcinoma as ovarian endometrioid carcinoma is not appropriate.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Oncology
J. Alejandro Perez-Fidalgo, Francisco Grau, Lorena Farinas, Ana Oaknin
Summary: Despite attempts to improve outcomes of advanced ovarian cancer patients with different strategies over the past few decades, the landscape of first-line treatment for AOC remained unchanged until the last three years.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Linda Hofmann, Marie Waizenegger, Ralph Roeth, Stefanie Schmitteckert, Daphne Engelhardt, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Summary: The impact of exosomes induced by conventional therapy on epithelial to mesenchymal transition (EMT) in head and neck squamous cell carcinoma (HNSCC) was analyzed in this study. The results showed that exosomes after therapy induced EMT in HNSCC cells, and exosomes from recurrent patients induced higher tumor cell migration than exosomes from disease-free patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemical Research Methods
Wei Zhou, Jiachen Ma, Han Zhao, Qing Wang, Xiaoli Guo, Linna Chen, Zhonghui Cao, Jiahao Xu, Bei Zhang, Xueyan Zhou
Summary: This study aimed to explore the proteomic profile of serum exosomes from epithelial ovarian cancer (EOC) patients and identify potential diagnostic markers for EOC. The researchers found that serum exosomes from EOC patients contributed to the migration of EOC cells and the level of exosomal LRPI was significantly upregulated in EOC patients, serving as an important diagnostic and prognostic biomarker for EOC.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Obstetrics & Gynecology
Angel Chao, Ren-Chin Wu, An-Shine Chao, Wei-Yang Chang, Chen-Hsuan Wu, Chyong-Huey Lai, Lan-Yan Yang
Summary: The occurrence of synchronous/metachronous endometrial cancer (EC) and colorectal cancer (CRC) is relatively low but carries a high risk of developing into metachronous tumors. Surveillance for CRC is recommended for women diagnosed with EC. Synchronous EC/CRC has poor clinical outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Surgery
Ching Feng Wu, Ching Yang Wu, Yin Kai Chao, Diego Gonzalez-Rivas, Ming Ju Hsieh, Yu Bin Pan, Lan Yan Yang
Summary: This study evaluated the feasibility of using the unisurgeon approach in single-port video-assisted thoracoscopic surgery aided by a robotic camera holder. The results showed that in wedge resections, a single surgeon can successfully operate on all target lesions, while the success rate is lower in anatomical resections. There were no significant differences in setup times, blood loss, or operative times between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Chun Chen, Huei-Jean Huang, Lan-Yan Yang, Yu-Bin Pan, Kuan-Gen Huang, Cheng-Tao Lin, Min-Yu Chen, Yun-Hsin Tang, Ting-Chang Chang, Chyong-Huey Lai, Hung-Hsueh Chou
Summary: Secondary cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has potential benefits for patients with recurrent ovarian cancer, with factors such as previous chemotherapy, chemotherapy-free interval, and CA125 levels before HIPEC contributing to prognosis. However, there are also associated toxicities.
BIOMEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Hsi-Chen Tsai, Kung-Chu Ho, Shih-Hsin Chen, Jing-Ren Tseng, Lan-Yan Yang, Kun-Ju Lin, Ju-Chin Cheng, Miaw-Jene Liou
Summary: This study found that using rhTSH stimulation for preparation of RAI therapy is not inferior to THW preparation for patients with PTC and distant metastasis. Patients with RAI-avid metastases and preparation with rhTSH had the most favorable progression-free survival (PFS).
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Obstetrics & Gynecology
Wei-Chun Chen, Hextan Y. S. Ngan, Lan-Yan Yang, Wei-Yang Chang, Ren-Chin Wu, Chao-Yu Chen, Hao Lin, Ya-Min Cheng, Yuen-Yee Kan, Chih-Jen Tseng, Cheng-Chang Chang, Shih-Ming Jung, Hsiu-jung Tung, Yun-Hsin Tang, Cheng-Tao Lin, Angel Chao, Chyong-Huey Lai
Summary: This study validated HPV16 as an independent good prognostic factor for cervical adenocarcinoma and adenosquamous carcinoma (AD/ASC). Patients with HPV16-positive tumors had better progression-free survival (PFS) and overall survival (OS). Additionally, primary surgery seemed to lead to better outcomes compared to non-primary surgery.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Oncology
Jing-Ren Tseng, Szu-Han Chang, Yao-Yu Wu, Kang-Hsing Fan, Kai-Jie Yu, Lan-Yan Yang, Ing-Tsung Hsiao, Feng-Yuan Liu, See-Tong Pang
Summary: This pilot study evaluated the response of PSMA PET/CT imaging in 30 patients after three months of androgen deprivation therapy (ADT). Most patients showed a reduction in PSMA PET/CT indices, with 80% being partial responders. Patients with higher grade prostate cancer showed a less prominent reduction in imaging indices. These findings suggest that PSMA PET/CT imaging is clinically useful for monitoring treatment response after the first three months of ADT.
Article
Medicine, General & Internal
Chong Kei Lao, Mei-Chueh Tseng, Cheng-Hsun Chiu, Nan-Yu Chen, Chih-Hung Chen, Wen-Hung Chung, Tsui-Ping Liu, Jang-Jih Lu, Hsin-Chih Lai, Lan-Yan Yang, Chia-Hui Lee, Ting-Shu Wu
Summary: This study assessed the clinical characteristics of patients with nocardiosis, evaluated the susceptibility of Nocardia species to antimicrobial agents, and investigated changes in antimicrobial susceptibilities. The findings suggest that trimethoprim-sulfamethoxazole is the preferred antibiotic in Taiwan, and amikacin, tigecycline, and linezolid are alternative treatment options for nocardiosis.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Angel Chao, Shu-Jen Chen, Hua-Chien Chen, Kien Thiam Tan, Wen Hsiao, Shih-Ming Jung, Lan-Yan Yang, Kuan-Gen Huang, Hung-Hsueh Chou, Huei-Jean Huang, Ting-Chang Chang, An-Shine Chao, Yun-Hsien Lee, Ren-Chin Wu, Chyong-Huey Lai
Summary: This study investigated the prognostic impact of mutations in plasma circulating tumor DNA (ctDNA) in patients with ovarian carcinoma and examined the concordance of mutations in ctDNA samples with those in formalin-fixed paraffin-embedded (FFPE) tumor specimens. The results showed that ctDNA mutations were common in ovarian carcinoma patients, and the presence of ctDNA mutations after surgery was an independent predictor of unfavorable progression-free survival (PFS) and overall survival (OS).
BIOMEDICAL JOURNAL
(2023)
Article
Obstetrics & Gynecology
Chin-Chieh Hsu, Chih-Yang Lai, Ho-Yen Chueh, Po-Jen Cheng, Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Chyong-Huey Lai, Liang-Ming Lo, Yu-Bin Pan, Lan-Yan Yang, Yi-Hsun Yu
Summary: This retrospective cohort study aimed to report obstetric outcomes in pregnant women with previous pelvic ring injury (PRI) and investigate the correlation between residual pelvic deformity and the mode of delivery. The results showed that vaginal delivery (VD) is possible after PRI, retained trans-iliosacral implants do not affect the delivery outcome, and residual pelvic asymmetry measured by Lefaivre criteria is a potential risk factor for caesarean section (CS) after previous PRI.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Mayank Jayaram, Shannon M. Wood, Robert L. Kane, Lan-Yan Yang, Kevin C. Chung
Summary: This meta-analysis examines the short- and intermediate-term outcomes of various treatments for distal radius fracture in older adults. The findings suggest that open reduction and internal fixation with volar lock plating (ORIF) may lead to significant improvements in short-term recovery compared to casting, with no increase in 1-year complications.
Article
Biology
Chun-Bi Chang, Yu-Chun Lin, Yon-Cheong Wong, Shin-Nan Lin, Chien-Yuan Lin, Yu-Han Lin, Ting-Wen Sheng, Lan-Yan Yang, Li-Jen Wang
Summary: This study found that preoperative DCE-MRI parameters, specifically Ktrans-max and k(ep-max), could potentially serve as preoperative imaging biomarkers for postoperative prostate cancer prognosis, predicting ISUP grade and positive surgical margins.
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ting-Yao Wang, Chao-Yu Chen, Tzu-Hao Huang, Yao-Hsu Yang, Ko-Jung Chen, Wen-Chi Chou, Chang-Hsien Lu
Summary: This study evaluated the efficacy of protein-bound polysaccharide K (PSK) in gastric cancer patients. Through a population-based historical cohort study using the National Health Insurance Research Database of Taiwan, it was found that adjuvant chemotherapy combined with PSK significantly prolonged overall survival in patients after gastrectomy.