Journal
NUTRITION REVIEWS
Volume 66, Issue 1, Pages 55-59Publisher
OXFORD UNIV PRESS INC
DOI: 10.1111/j.1753-4887.2007.00006.x
Keywords
cellular retinoic acid-binding protein-II; fatty acid-binding protein 5; keratinocytes; mammary carcinoma MCF-7; peroxisome proliferator-activated receptor beta/delta; retinoic acid receptor
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Retinoic acid can combine with the nuclear retinoic acid receptor (RAR), leading to cell growth inhibition, as in certain tumors. Retinoic acid can also bind to the orphan nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta), resulting in stimulation of cell growth and inhibition of apoptosis. To bind to RAR, retinoic acid is carried into the nucleus by the cytosolic cellular retinoic acid-binding protein-II; to bind to PPAR beta/delta, it is transported into the nucleus by the cytosolic fatty acid-binding protein 5. (c) 2008 International Life Sciences Institute.
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