Article
Food Science & Technology
Viola Galli, Manuel Venturi, Eleonora Mari, Simona Guerrini, Lisa Granchi
Summary: This study found that certain strains of lactic acid bacteria can release bioactive compounds, such as GABA, in fermented milk, which have positive effects on human health. By selecting and combining different strains, fermented milk products with high GABA concentrations can be produced.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Environmental Sciences
Katlyn E. McGraw, Daniel W. Riggs, Shesh Rai, Ana Navas-Acien, Zhengzhi Xie, Pawel Lorkiewicz, Jordan Lynch, Nagma Zafar, Sathya Krishnasamy, Kira C. Taylor, Daniel J. Conklin, Andrew P. DeFilippis, Sanjay Srivastava, Aruni Bhatnagar
Summary: Exposure to acrolein and 1,3-butadiene is associated with endothelial dysfunction and may contribute to increased risk of hypertension in individuals with elevated sympathetic tone, particularly in Black participants.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemical Research Methods
Pieter M. Dekker, Sjef Boeren, Johannes B. van Goudoever, Jacques J. M. Vervoort, Kasper A. Hettinga
Summary: The study found significant interindividual variation in proteins and peptides in human milk, and identified distinct characteristics in different protein and peptide clusters through weighted correlation network analysis. Several associations between different data sets and specific sample characteristics were also discovered.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Critical Care Medicine
Mia DelVechio, Juliano Alves, Alina Z. Saiyid, Shubhnita Singh, Joseph Galley, Wanessa M. C. Awata, Rafael M. Costa, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento
Summary: This study investigates the relationship between Kawasaki disease and vascular function and blood pressure using a murine model. The findings suggest that Kawasaki disease may be associated with vascular dysfunction, which may be dependent on COX-derived products, oxidant properties, and NO bioavailability. Vascular smooth muscle cells may play an important role in the development of vascular dysfunction and vasculitis via the Toll-like receptor 4 pathway. However, the CAWS model seems inappropriate for studying Kawasaki disease-associated shock. Further studies are needed to understand whether vascular dysfunction and COXs are triggers for vasculitis.
Review
Nutrition & Dietetics
Monica Volino-Souza, Gustavo Vieira de Oliveira, Carlos Adam Conte-Junior, Arturo Figueroa, Thiago Silveira Alvares
Summary: L-arginine is crucial for nitric oxide synthesis and supplementation with its precursor L-citrulline, found in watermelon, can improve vascular function. However, there are differing findings on the effect of watermelon supplementation, possibly due to varying L-citrulline doses. Food technology can be applied to concentrate L-citrulline content and reduce volume for convenient ingestion. Watermelon-derived L-citrulline appears to be an effective supplementation for improving vascular health.
Review
Food Science & Technology
Haohai Huang, Guanghui Zhou, Rong Pu, Yejia Cui, Dan Liao
Summary: The meta-analysis study found that sesame consumption can reduce the risk of cardiovascular disease and improve blood lipids, blood pressure, and body weight management. This conclusion is stable and reliable, but further large-scale studies are needed to verify it.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Medicinal
Hadi Emamat, Seyyed Hossein Mousavi, Jalal Kargar Shouraki, Ebrahim Hazrati, Sayid Mahdi Mirghazanfari, Esmaeil Samizadeh, Maryam Hosseini, Vahid Hadi, Saeid Hadi
Summary: This study found that N. sativa oil can improve vascular NO and FMD levels in participants with cardiovascular risk factors, but more research is needed to confirm its benefits on vascular inflammation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Food Science & Technology
Xin Ma, Fan Yang, Xuanyi Meng, Yong Wu, Ping Tong, Jinyan Gao, Hongbing Chen, Xin Li
Summary: This study identified 109 BLG-derived peptides from simulated digestion of cow's milk, which showed good transport absorption capacity in Caco-2 cells. Some peptides were found to promote activation of DC and T cells.
Review
Biochemistry & Molecular Biology
Nurul Sulimai, Jason Brown, David Lominadze
Summary: Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). Local regulation of blood flow in the brain is determined by neurons and astrocytes. Changes in cerebral vessels, particularly in cerebrovascular permeability, play a crucial role in the development and progression of neuroinflammatory and neurodegenerative diseases, resulting in memory decline.
Article
Biochemistry & Molecular Biology
Sri Vidya Dangudubiyyam, Bradley Bosse, Pankaj Yadav, Ruolin Song, Alissa Hofmann, Jay S. Mishra, Sathish Kumar
Summary: This study found that AT2R activation can improve maternal vascular dysfunction and blood flow caused by PFOS exposure, restoring normal fetal growth. This provides important preclinical evidence for the prevention or treatment of adverse maternal and fetal outcomes caused by PFOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lin-Juan Du, Jian-Yong Sun, Wu-Chang Zhang, Yuan Liu, Yan Liu, Wen-Zhen Lin, Ting Liu, Hong Zhu, Yong-Li Wang, Shuai Shao, Lu-Jun Zhou, Bo-Yan Chen, Hongjian Lu, Ruo-Gu Li, Feng Jia, Sheng-Zhong Duan
Summary: Deficiency of smooth muscle NCOR1 can lead to phenotypic alteration of VSMCs, switching them from a contractile phenotype to a degradative phenotype, thereby promoting the development of aortic aneurysm (AA). NCOR1 interacts with FOXO3a, NFAT5, and ATF3 to maintain the contractile phenotype of VSMCs and suppress AA development. These findings provide a new potential approach for the treatment of AA.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Li Chen, Linlin Wang, Jianke Li, Guowei Shu
Summary: Fermented milk by certain lactic acid bacteria (LAB) provides energetic contributions to hypertension management with a focus on the regulation of ACE. The research progress of LAB proteolytic systems and their correlation with ACE inhibitory activity provide a promising direction for future studies. Functional annotation of LAB proteolytic system genes may serve as a framework for experimental validations of predicted ACE inhibitory activity in fermented milk.
Article
Cardiac & Cardiovascular Systems
Ariane Bruder-Nascimento, Wanessa M. C. Awata, Juliano V. Alves, Shubhnita Singh, Rafael M. Costa, Thiago Bruder-Nascimento
Summary: The study found that circulating protein Progranulin regulates vascular tone and blood pressure through activation of EphrinA2 and Sortilin1 receptors and endothelial nitric oxide synthase. The results showed that deficiency in Progranulin leads to hypertension and excessive vascular contraction. Therefore, Progranulin might be a new therapeutic avenue to treat high blood pressure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Nutrition & Dietetics
Irfa Anwar, Farheen Badrealam Khan, Sajid Maqsood, Mohammed Akli Ayoub
Summary: This review focuses on the targeting of insulin receptor (IR) by camel milk (CM) components and the investigation of their effects on IR and its related signaling pathways. The study demonstrates that CM proteins and derived peptides positively modulate IR and could potentially be used as antidiabetic agents. The findings provide insights into the molecular basis of CM's antidiabetic properties and have implications for the development of new antidiabetic tools.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Morgan L. Worley, Morgan C. O'Leary, James R. Sackett, Zachary J. Schlader, Barry Willer, John J. Leddy, Blair D. Johnson
Summary: Athletes with concussions show impaired tolerance to lower body negative pressure and have a different cerebral vascular response to lower body positive pressure compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2021)