Article
Entomology
Fatma Boukid, Jordi Riudavets, Lidia del Arco, Massimo Castellari
Summary: Insects are a potential source of lipids, with fatty acid compositions and sterols varying depending on diet composition and species. H. illucens has low cholesterol but high campesterol and beta-sitosterol levels, while T. molitor and E. kuehniella have high cholesterol and low campesterol contents. Rearing insects on agro-industrial by-products can be a sustainable strategy for the circular economy, providing valuable fat sources for humans and animals.
Article
Chemistry, Medicinal
Xiaoyue Li, Beibei Zeng, Lu Wen, Yingcai Zhao, Zhaojie Li, Changhu Xue, Tiantian Zhang, Yuming Wang
Summary: This study found that the sea cucumber saponin derivative EA2 has a good lipid-lowering effect, effectively alleviating lipid accumulation and regulating lipid metabolism through multiple mechanisms.
Article
Chemistry, Analytical
Lan Chen, Fengming Chen, Tong Liu, Feng Feng, Wei Guo, Yuan Zhang, Xuesong Feng, Jin-Ming Lin, Feng Zhang
Summary: This study proposes a comprehensive method combining ion mobility mass spectrometry (IMS) and chemometrics to accurately identify biomarkers for cell interference by mycotoxins. The integration of UPLC-TOF-IMS and chemometrics provides a new approach for discovering lipid biomarkers and prognostic indicators for mycotoxins.
ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Pan Gao, Ruijie Liu, Qingzhe Jin, Xingguo Wang
Summary: Different processing methods did not affect the lipid composition of walnut oil. Roast-pressed walnut oil had higher tocopherol and total phenolic content, while subcritical butane-extracted walnut oil had higher phytosterol content. Walnut oil reduced cholesterol synthesis by downregulating certain genes and increased cholesterol efflux by upregulating other genes, leading to a significant reduction in total cholesterol and triacylglycerol.
Review
Food Science & Technology
Jing-Wen Yang, Hong-Fang Ji
Summary: Phytosterols are bioactive food components found in plant cell membranes, especially in nuts and oilseeds. Many studies have shown their therapeutic potential for nonalcoholic fatty liver disease (NAFLD). They lower total cholesterol and triglyceride levels through various mechanisms and improve NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Xiaolan Bao, Xingyu Yuan, Xuexin Li, Xiaojing Liu
Summary: The study isolated IPPF from flaxseed protein, which effectively reduces serum cholesterol levels, modulates cholesterol metabolism, and has potential nutritional therapeutic value.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Cell Biology
Alexander L. Ticho, Nathan Calzadilla, Pooja Malhotra, Hyunjin Lee, Arivarasu Natarajan Anbazhagan, Seema Saksena, Pradeep K. Dudeja, Daesung Lee, Ravinder K. Gill, Waddah A. Alrefai
Summary: Research suggests that 27-alkyne cholesterol acts as a substrate for NPC1L1 in cholesterol absorption, serving as a potential nonradioactive tracer for measuring cholesterol absorption in both in vitro and in vivo models.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isy F. de Sousa, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Ivana Caputo, Eliane Beraldi Ribeiro, Lilla Lionetti
Summary: This study evaluated the dose- and time-dependent effects of oleate and palmitate on mitochondrial fusion/fission proteins, finding that oleate had minimal impact on protein content and maintained cell viability, while palmitate reduced protein content and cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ramesh Kumar Saini, Ji-Woo Yu, Min-Ho Song, Hui-Yeon Ahn, Jung-Hoon Lee, Young-Soo Keum, Ji-Ho Lee
Summary: This research provides information on the contents and composition of important lipophilic constituents in leaf mustard, including carotenoids, tocols, phytosterols, and fatty acids. Among the four cultivars studied, Cheong had the highest levels of carotenoids and tocols, while Red frill contained the most n-3 PUFAs and antioxidants.
Article
Food Science & Technology
Taotao Wang, Hong Xu, Yu Guo, Zhanming Li, Hua Ye, Liang Wu, Yuanxin Guo, Dongxu Wang
Summary: Perfluorodecanoic acid (PFDA) is a toxic persistent pollutant used in food packaging and cookware. Studies have shown that exposure to PFDA is associated with higher plasma triglyceride concentration in humans. This study investigated the effects and mechanisms of PFDA on lipid metabolism. The results demonstrated that PFDA promotes cellular triglyceride accumulation in a concentration-dependent manner and activates the NLRP3 inflammasome. Furthermore, PFDA-induced adipogenesis was mediated by the NLRP3 inflammasome and the SREBP1 pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Yuchuan Li, Manoj Amrutkar, Anette Vefferstad Finstadsveen, Knut Tomas Dalen, Caroline S. Verbeke, Ivar P. Gladhaug
Summary: Targeting cholesterol flux may be an attractive strategy to develop new therapeutics against pancreatic ductal adenocarcinoma (PDAC). Disturbing the cholesterol flux by inhibiting its key regulators can suppress PDAC cell growth. The presence of fatty acids restores intracellular cholesterol balance and reverses the alterations induced by cholesterol flux inhibitors. However, the impact of fatty acids in the tumor microenvironment should be considered.
CANCER CELL INTERNATIONAL
(2023)
Article
Food Science & Technology
Yuhao Yuan, Chunjuan Liu, Guan Zhao, Xiangwei Gong, Ke Dang, Qinghua Yang, Baili Feng
Summary: This study investigated the dynamic changes of beneficial compounds during seed development in different foxtail millet cultivars, revealing fluctuations in oil content, unsaturated fatty acids, and phytosterols accumulation. Key genes related to fatty acid and phytosterol biosynthesis were found to be overexpressed in the cultivar with higher crude fat content, leading to maximum accumulation of these bioactive compounds at a specific stage of seed development.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Dorota Bederska-Lojewska, Marek Pieszka, Aleksandra Marzec, Magdalena Rudzinska, Anna Grygier, Aleksander Siger, Katarzyna Cieslik-Boczula, Sylwia Orczewska-Dudek, Wladyslaw Migdal
Summary: This study developed a novel technology for extracting active substances from fruit seeds obtained after pressing fruit juices, which is safe and effective in obtaining valuable oils from the seeds.
Article
Biochemistry & Molecular Biology
Francisca S. Teixeira, Ligia L. Pimentel, Susana S. M. P. Vidigal, Joao Azevedo-Silva, Manuela E. Pintado, Luis M. Rodriguez-Alcala
Summary: Lipid metabolism pathways play a crucial role in liver function, but the accumulation of lipids in hepatic cells can lead to steatosis, a growing pathology. This study investigated the accumulation of palmitic and linoleic fatty acids on hepatocytes and found that linoleic acid induced more reactive oxygen species (ROS) production compared to palmitic acid. Moreover, a lipid profile modification was observed after exposure to both fatty acids, highlighting the importance of balancing their concentrations to maintain normal levels of free fatty acids, cholesterol, and triglycerides in liver cells.
Article
Biochemistry & Molecular Biology
Kihwan Song, Ramesh Kumar Saini, Young-Soo Keum, Iyyakkannu Sivanesan
Summary: This study analyzed the lipophilic antioxidant profile in the leaves of Kaempferia parviflora plants and found that ex vitro-cultivated leaves contained higher levels of important lipophilic antioxidants compared to in vitro-cultivated leaves. This suggests that ex vitro-grown Kaempferia parviflora leaves could be a valuable natural source for extracting key lipophilic antioxidants.