Article
Cardiac & Cardiovascular Systems
Maria Bergami, Edina Cenko, Jinsung Yoon, Guiomar Mendieta, Sasko Kedev, Marija Zdravkovic, Zorana Vasiljevic, Davor Milicic, Olivia Manfrini, Mihaela van der Schaar, Chris P. Gale, Lina Badimon, Raffaele Bugiardini
Summary: Preventive statin therapy in the elderly reduces the risk of ST-segment elevation myocardial infarction (STEMI) and has benefits in mortality, regardless of the presence of hypercholesterolemia history. This effect persists after the age of 76 years, but the benefits are less pronounced in women.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Maneesh Sud, Atul Sivaswamy, Peter C. Austin, Husam Abdel-Qadir, Todd J. Anderson, Rohan Khera, David M. J. Naimark, Douglas S. Lee, Idan Roifman, George Thanassoulis, Karen Tu, Harindra C. Wijeysundera, Dennis T. Ko
Summary: The study validated the European-developed SCORE2 models in predicting cardiovascular disease risk in a large Canadian cohort, showing varied performance by age group and the importance of regional calibration for accuracy. Independent assessment of tools like SCORE2 is crucial before implementation in new regions.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Kamal Awad, Maged Mohammed, Mahmoud Mohamed Zaki, Abdelrahman I. Abushouk, Gregory Y. H. Lip, Michael J. Blaha, Carl J. Lavie, Peter P. Toth, J. Wouter Jukema, Naveed Sattar, Maciej Banach
Summary: Statin therapy in older people for primary prevention of cardiovascular disease is associated with significantly lower risks of all-cause mortality, CVD death, and stroke, but not with myocardial infarction. The observational findings support the need for further trials to test the benefits of statins in individuals above 75 years of age.
Article
Multidisciplinary Sciences
Manel Boumegouas, Manjunath Raju, Joseph Gardiner, Neal Hammer, Yehia Saleh, Abdullah Al-Abcha, Apoorv Kalra, George S. Abela
Summary: This study is the first to demonstrate an interaction between pathogenic bacteria and cholesterol crystals (CCs), showing that bacteria dissolve and bind to CCs. This interaction helps to elucidate adhesion of bacteria to sclerotic valves and atherosclerotic plaques, which may contribute to endocarditis and plaque destabilization.
Article
Pharmacology & Pharmacy
Stella Trompet, Iris Postmus, Helen R. Warren, Raymond Noordam, Roelof A. J. Smit, Elizabeth Theusch, Xiaohui Li, Benoit Arsenault, Daniel I. Chasman, Graham A. Hitman, Patricia B. Munroe, Jerome I. Rotter, Bruce M. Psaty, Mark J. Caulfield, Ron M. Krauss, Adrienne L. Cupples, Wouter J. Jukema
Summary: The pharmacogenetic effect of genetic variation on cardiovascular disease risk reduction in response to statin treatment was investigated through a genome-wide association study (GWAS). The results showed that genetic variation did not significantly affect the response of statins on cardiovascular risk reduction. This suggests that genetic testing for predicting the effects of statins on clinical events may not be a useful tool in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dirk von Lewinski, Ewald Kolesnik, Faisal Aziz, Martin Benedikt, Norbert J. Tripolt, Markus Wallner, Peter N. Pferschy, Friederike von Lewinski, Nora Schwegel, Rury R. Holman, Abderrahim Oulhaj, Deddo Moertl, Jolanta Siller-Matula, Harald Sourij
Summary: Very early administration of SGLT2 inhibitors after acute myocardial infarction appears to be safe and effective in reducing NT-proBNP, as well as improving structural and functional left ventricular markers. There is no significant difference in severe adverse event rate between different initiation time groups.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Nursing
Angel Lizcano-Alvarez, Laura Carretero-Julian, Ana Talavera-Saez, Beatriz Cristobal-Zarate, Maria-Gema Cid-Exposito, Almudena Alameda-Cuesta
Summary: This study aims to assess the effects of intensive follow-up by primary care nurses on cardiovascular disease self-management and compliance behaviors after myocardial infarction. The results show that intensive follow-up after myocardial infarction can improve patients' compliance behaviors and self-management, and a combined self-care and family care approach should be encouraged. Health education tools such as a cardiovascular self-care notebook can also be helpful in facilitating patients' self-efficacy.
Article
Medicine, General & Internal
Oreste Lanza, Nicola Cosentino, Claudia Lucci, Marta Resta, Mara Rubino, Valentina Milazzo, Monica De Metrio, Filippo Trombara, Jeness Campodonico, Jose Pablo Werba, Alice Bonomi, Giancarlo Marenzi
Summary: Prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Monica Verdoia, Filippo Viglione, Annalisa Boggio, Daniele Stefani, Nicolo Panarotto, Aurelio Malabaila, Roberta Rolla, Pier Luigi Solda, Alessandro Stecco, Alessandro Carriero, Giuseppe De Luca
Summary: This study aimed to assess the impact of vitamin D on cholesterol levels among patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI). The results showed that lower levels of vitamin D were independently associated with a more atherogenic lipid profile.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Chemistry, Medicinal
Konrad Stepien, Karol Nowak, Natalia Kachnic, Grzegorz Horosin, Piotr Walczak, Aleksandra Karcinska, Tomasz Schwarz, Mariusz Wojtas, Magdalena Zalewska, Maksymilian Pastuszak, Bogdan Wegrzyn, Jadwiga Nessler, Jaroslaw Zalewski
Summary: The use of statins in the treatment of myocardial infarction patients has a significant impact on long-term clinical outcomes, and this impact is even more crucial in patients with active cancer.
Article
Medicine, General & Internal
Loes T. C. M. Wouters, Dorien L. M. Zwart, Daphne C. A. Erkelens, Elisabeth J. M. Adriaansen, Hester M. den Ruijter, Esther De Groot, Roger A. M. J. Damoiseaux, Arno W. Hoes, Maarten van Smeden, Frans H. Rutten
Summary: The study aimed to develop and validate a symptom-based prediction rule for early recognition of acute coronary syndrome (ACS) in patients who call out-of-hours services for primary care. The final prediction model showed good discrimination and calibration, and showed promise for replacing existing telephone triage rules.
Article
Medicine, General & Internal
Daniel M. Blumenthal, Sidney E. Howard, Jennifer Searl Como, Sandra M. O'Keefe, Steven J. Atlas, Daniel M. Horn, Neil W. Wagle, Jason H. Wasfy, Robert W. Yeh, Joshua P. Metlay
Summary: Among stable outpatients with CAD receiving primary care through an integrated primary care network, 21.2% of surveyed patients reported experiencing angina at least once monthly. Several objective demographic and clinical characteristics were associated with angina frequency.
Article
Cardiac & Cardiovascular Systems
Francois Schiele, Nadia Quignot, Artak Khachatryan, Gaelle Gusto, Guillermo Villa, Doreen Kahangire, Jean-Vannak Chauny, Lea Ricci, Gaelle Desamericq
Summary: The study found that high-intensity LLT prescriptions were limited and adherence to LLT was low among patients with a history of myocardial infarction. Higher treatment intensity, adherence, and adherence-adjusted intensity were all associated with a significantly lower risk of major adverse cardiovascular events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chandini Raina MacIntyre, Abrar Ahmad Chughtai, Arpita Das, Bayzidur Rahman, Aye M. Moa, Chieh H. Gan, Timothy C. Tan
Summary: The study found a significantly higher rate of laboratory-confirmed influenza among statin users who were not vaccinated. However, there was no significant difference in influenza vaccine effectiveness between statin users and non-users after vaccination. Statin users had a significantly higher risk of influenza, suggesting that they should be vaccinated against influenza.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Takuhiro Shirakawa, Koichiro Fujisue, Shinichi Nakamura, Nobuyasu Yamamoto, Shuichi Oshima, Toshiyuki Matsumura, Ryusuke Tsunoda, Nobutaka Hirai, Shunichi Koide, Shinji Tayama, Koichi Kikuta, Toyoki Hirose, Hideki Maruyama, Kazuteru Fujimoto, Ichiro Kajiwara, Tomohiro Sakamoto, Koichi Nakao, Naritsugu Sakaino, Yasuhiro Nagayoshi, Jun Hokamaki, Hideki Shimomura, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa, Kenichi Tsujita
Summary: This study could not demonstrate the superiority of appropriate dose of rosuvastatin in inhibiting serum MMP levels in patients with AMI.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Nutrition & Dietetics
Gesa Czwikla, Filip Boen, Derek G. Cook, Johan de Jong, Tess Harris, Lisa K. Hilz, Steve Iliffe, Lilian Lechner, Richard W. Morris, Saskia Muellmann, Denise A. Peels, Claudia R. Pischke, Benjamin Schuz, Martin Stevens, Klaus Telkmann, Frank J. van Lenthe, Julie Vanderlinden, Gabriele Bolte
Summary: The study established a novel equity-specific re-analysis strategy and applied it to a convenience sample of eight European PA intervention studies, finding no consistent pattern of equity-specific intervention effects.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Geriatrics & Gerontology
Shaleen Ahmad, Iain M. Carey, Tess Harris, Derek G. Cook, Stephen DeWilde, David P. Strachan
Summary: The research showed that recording of dementia increased between 2001 and 2015 in all data sources. However, death certificates were still not providing a complete picture of the number of people dying with dementia, with many cases not recorded.
Article
Public, Environmental & Occupational Health
Pallavi Mishra, Sheila Margaret Greenfield, Tess Harris, Mark Hamer, Sarah Anne Lewis, Kavita Singh, Rukamani Nair, Somnath Mukherjee, Nandi Krishnamurthy Manjunath, David Ross Harper, Nikhil Tandon, Sanjay Kinra, Dorairaj Prabhakaran, Kaushik Chattopadhyay
Summary: The study identified and explored personal, contextual, and study-related barriers that prevented participation in a feasibility RCT in India, such as lack of time, social influences, and lack of study information. These findings will help address recruitment challenges in future Yoga and other RCTs.
FRONTIERS IN PUBLIC HEALTH
(2021)
Editorial Material
Pharmacology & Pharmacy
Christopher J. D. Threapleton, Tess Harris, Emma H. Baker
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Iain M. Carey, Emma Banchoff, Niranjanan Nirmalananthan, Tess Harris, Stephen DeWilde, Umar A. R. Chaudhry, Derek G. Cook
Summary: Analysis of recording of neuromuscular disease in UK primary care showed an overall increase in prevalence, especially among older age groups. While specific diseases showed varying trends in incidence, the overall incidence remained constant over the study period.
Article
Multidisciplinary Sciences
Iain M. Carey, Derek G. Cook, Tess Harris, Stephen DeWilde, Umar A. R. Chaudhry, David P. Strachan
Summary: The study identified factors such as age, non-white ethnicity, obesity, cognitive impairment, learning disabilities, severe mental illness, and place of residence that were closely associated with excess mortality during the COVID-19 pandemic in England. In contrast, gender did not show a significant association. While some comorbidities led to a decrease in excess mortality rates, they still remained higher than usual levels.
Article
Environmental Sciences
Pallavi Mishra, Tess Harris, Sheila Margaret Greenfield, Mark Hamer, Sarah Anne Lewis, Kavita Singh, Rukamani Nair, Somnath Mukherjee, Nandi Krishnamurthy Manjunath, Nikhil Tandon, Sanjay Kinra, Dorairaj Prabhakaran, Kaushik Chattopadhyay
Summary: This study aimed to identify and explore the barriers and facilitators faced by participants in yoga-based interventions for the prevention of type 2 diabetes mellitus (T2DM). The study found that participants in the trial faced barriers such as inadequate information about recruitment and randomization processes and the negative influence of non-participants. On the other hand, participants in the intervention faced barriers such as poor quality yoga mats and difficulty in using the program video. However, there were also facilitators for both the trial and intervention, such as friendly staff behavior and friends' positive influence.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Robyn J. Tapp, Christopher G. Owen, Sarah A. Barman, David P. Strachan, Roshan A. Welikala, Paul J. Foster, Peter H. Whincup, Alicja R. Rudnicka
Summary: The study found clear associations between retinal microvascular architecture and cardiometabolic risk factors in patients with diabetes, indicating potential preclinical disease processes and suggesting impaired autoregulation due to hyperglycemia may play a pivotal role in the development of diabetes-related microvascular complications.
Article
Substance Abuse
Adrian H. Taylor, Tom P. Thompson, Adam Streeter, Jade Chynoweth, Tristan Snowsill, Wendy Ingram, Michael Ussher, Paul Aveyard, Rachael L. Murray, Tess Harris, Lynne Callaghan, Colin Green, Colin J. Greaves, Lisa Price, Siobhan Creanor
Summary: Behavioral support can effectively reduce smoking and increase physical activity for smokers who are unmotivated to quit, but it does not have long-term effects on smoking cessation and physical activity.
Article
Endocrinology & Metabolism
Iain M. Carey, Julia A. Critchley, Umar A. R. Chaudhry, Stephen DeWilde, Elizabeth S. Limb, Derek G. Cook, Peter H. Whincup, Tess Harris
Summary: People with T2D and prediabetes have a higher risk of infection, with no significant differences in risk between different ethnic groups. Infections are a significant health issue and burden on healthcare resources for individuals with T2D and prediabetes.
Article
Health Care Sciences & Services
Adrian H. Taylor, Tom P. Thompson, Adam Streeter, Jade Chynoweth, Tristan Snowsill, Wendy Ingram, Michael Ussher, Paul Aveyard, Rachael L. Murray, Tess Harris, Colin Green, Jane Horrell, Lynne Callaghan, Colin J. Greaves, Lisa Price, Lucy Cartwright, Jonny Wilks, Sarah Campbell, Dan Preece, Siobhan Creanor
Summary: This study examined the effect of motivational support for smokers who wanted to reduce smoking but not quit immediately. The intervention, which aimed to increase physical activity and reduce smoking, did not lead to significant increases in prolonged abstinence. Additionally, the intervention was not cost-effective.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Multidisciplinary Sciences
Iain Carey, Niranjanan Nirmalananthan, Tess Harris, Stephen G. DeWilde, Umar A. R. Chaudhry, Elizabeth Limb, Derek Cook
Summary: This study compared the prevalence of chronic diseases and health conditions between patients with neuromuscular disease (NMD) and those without using a large UK primary care database. The results showed that patients with NMD had higher rates of chronic diseases and were more likely to have acute events such as infections compared to the general population.
Article
Surgery
Emma Rose Mcglone, Iain M. Carey, Andrew Currie, Kamal Mahawar, Richard Welbourn, Ahmed R. Ahmed, Chris Pring, Peter K. Small, Omar A. Khan
Summary: During the COVID-19 pandemic, there was a significant decrease in total number of elective bariatric surgeries in the UK, with 32% of hospitals experiencing a 75%-100% reduction in surgery volume. The proportion of cases performed in the National Health Service dropped from 74% to 53%, with no changes in baseline body mass index and prevalence of type 2 diabetes. Length of stay and surgical complication rate remained unchanged as well.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Meeting Abstract
Surgery
Emma Rose McGlone, Iain Carey, Andrew Currie, Kamal Mahawar, Richard Welbourn, Ahmed Ahmed, Chris Pring, Peter Small, Omar Khan
Meeting Abstract
Surgery
Andrew Currie, Emma-Rose McGlone, Kamal Mahawar, Dimitri Pournaras, Iain Carey, Richard Welbourn, Ahmed Ahmed, Omar Khan, Peter Small, Chris Pring