Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Surya Prakash Bhatt, Randeep Guleria, S. K. Kabra
Summary: The study aimed to determine the relationship between obstructive sleep apnea (OSA) in overweight/obese children and various inflammatory markers. It found that children with OSA have increased obesity, insulin resistance, and systemic inflammation, highlighting the need for further research to confirm these findings and evaluate their potential in diagnosing OSA and interventions.
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Adam Domonkos Tarnoki, David Laszlo Tarnoki, Csaba Olah, Marcell Szily, Daniel T. Kovacs, Andras Dienes, Marton Piroska, Bianka Forgo, Marina Pinheiro, Paulo Ferreira, Laszlo Kostyal, Martina Meszaros, Judit Pako, Laszlo Kunos, Andras Bikov
Summary: This study found that patients with OSA had more lumbar abnormalities compared to non-OSA controls, and markers of OSA severity were correlated with the development of lumbar spondylosis in these patients.
SCIENTIFIC REPORTS
(2021)
Review
Ophthalmology
Alex Jia Yang Cheong, Sean Kang Xuan Wang, Chang Yi Woon, Ki Han Yap, Kevin Joo Yang Ng, Flora Wen Xin Xu, Uri Alkan, Adele Chin Wei Ng, Anna See, Shaun Ray Han Loh, Tin Aung, Song Tar Toh
Summary: In this meta-analysis, OSA was found to be associated with a higher risk of glaucoma. After adjusting for confounding factors, patients with OSA had a 40% higher odds of developing glaucoma.
Article
Chemistry, Multidisciplinary
Andras Bikov, Helga Szabo, Marton Piroska, Laszlo Kunos, Marcell Szily, Balazs Ligeti, Nora Makra, Dora Szabo, David Laszlo Tarnoki, Adam Domonkos Tarnoki
Summary: Obstructive sleep apnoea (OSA) is associated with subtle changes in the gut microbiome, and further studies should investigate the role of gut dysbiosis in OSA.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Timothy P. Howarth, Natalie Gentin, Nayellin Reyes-Chicuellar, Catherine Jonas, Bruce Williamson, Greg Blecher, John Widger, Subash S. Heraganahally
Summary: This study found that Indigenous Australian children have issues with sleep quality, including a higher prevalence and severity of obstructive sleep apnoea, higher daytime sleepiness scores, later bedtimes, and reduced total sleep time compared to their non-Indigenous peers.
Article
Medicine, General & Internal
Andras Bikov, Stefan Frent, Oana Deleanu, Martina Meszaros, Mariela Romina Birza, Alina Mirela Popa, Andrei Raul Manzur, Loredana Gligor, Stefan Mihaicuta
Summary: The percentage of total sleep time spent with saturation below 90% (TST90%) may better predict cardiovascular consequences of obstructive sleep apnoea (OSA) than the number of obstructive respiratory events measured with the apnoea-hypopnea index (AHI). However, the additional value of the percentage of total sleep time spent with saturation below 80% (TST80%) to TST90% is not fully explored.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Andras Bikov, Stefan M. Frent, Martina Meszaros, Laszlo Kunos, Alexander G. Mathioudakis, Alina Gabriela Negru, Laura Gaita, Stefan Mihaicuta
Summary: OSA is associated with increased insulin resistance, and the triglyceride-glucose index (TyG) has been found to be significantly higher in OSA patients, related to disease severity. However, further evaluation in non-obese, non-diabetic subjects is needed to determine the clinical significance of TyG in OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Respiratory System
Margaret Gleeson, Walter T. McNicholas
Summary: Obstructive sleep apnoea (OSA) is often associated with various comorbidities, including metabolic, cardiovascular, renal, pulmonary, and neuropsychiatric conditions. There is evidence to suggest a bidirectional relationship between OSA and comorbidity, with some comorbidities possibly predisposing to the development of OSA. The impact of therapy in bidirectional relationships is also reviewed, emphasizing the importance of accurate diagnosis.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Nutrition & Dietetics
Surya Prakash Bhatt, Randeep Guleria
Summary: The study found that obese patients with OSA had lower serum vitamin D levels, which correlated with disease severity. Variations in VDR and PTH genes were highly associated with OSA in Asian Indians.
Review
Cardiac & Cardiovascular Systems
Eng Lee Ooi, Sharmalar Rajendran
Summary: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by airway obstruction during sleep, leading to breathing pauses and reduced oxygen levels. OSA patients often experience poor sleep quality and decreased quality of life. OSA is linked to both structural and functional coronary artery disease (CAD), caused by atherosclerosis and coronary vasomotor disorders respectively. Intermittent hypoxia (IH) and other factors play a significant role in the development of atherogenesis in OSA. While CPAP therapy has been associated with a decrease in cardiovascular events, randomized controlled trials have not shown its significance.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Respiratory System
Satu Strausz, Sanni Ruotsalainen, Hanna M. Ollila, Juha Karjalainen, Tuomo Kiiskinen, Mary Reeve, Mitja Kurki, Nina Mars, Aki S. Havulinna, Elina Luonsi, Dina Mansour Aly, Emma Ahlqvist, Maris Teder-Laving, Priit Palta, Leif Groop, Reedik Magi, Antti Makitie, Veikko Salomaa, Adel Bachour, Tiinamaija Tuomi, Aarno Palotie, Tuula Palotie, Samuli Ripatti
Summary: This study identified five genetic loci associated with OSA risk and found high genetic correlations between OSA and comorbidities such as obesity. The findings support a causal link between obesity and OSA, indicating a joint genetic basis between OSA and related health conditions.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Clinical Neurology
Mohit, Ashutosh Shrivastava, Pooran Chand
Summary: Obstructive sleep apnea (OSA) is characterized by recurrent episodes of upper airway obstruction during sleep and is influenced by genetic factors such as heritability and phenotypic co-factors. Inflammatory cytokine polymorphism and obesity are strongly associated with OSA development, and advanced techniques can facilitate new discoveries and reduce the risk of developing OSA.
Article
Medicine, Research & Experimental
Bharat Bhushan, Bushra Ayub, Dana M. Thompson, Fizan Abdullah, Kathleen R. Billings
Article
Otorhinolaryngology
Kevin C. Lewis, James W. Schroeder, Bushra Ayub, Bharat Bhushan
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2017)
Article
Otorhinolaryngology
Ashoke Khanwalkar, John Carter, Bharat Bhushan, Jeff Rastatter, John Maddalozzo
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2018)
Article
Otorhinolaryngology
Saied Ghadersohi, Bharat Bhushan, Kathleen R. Billings
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2018)
Article
Surgery
Katherine E. Hicks, Kathleen R. Billings, Chad A. Purnell, John M. Carter, Bharat Bhushan, Arun K. Gosain, Dana M. Thompson, Jeffrey C. Rastatter
JOURNAL OF CRANIOFACIAL SURGERY
(2018)
Editorial Material
Medicine, Research & Experimental
Bharat Bhushan
METABOLIC SYNDROME AND RELATED DISORDERS
(2018)
Article
Clinical Neurology
Bharat Bhushan, Amanda Beneat, Charles Ward, Alex Satinsky, Michael L. Miller, Lauren C. Balmert, John Maddalozzo
JOURNAL OF CLINICAL SLEEP MEDICINE
(2019)
Article
Otorhinolaryngology
Bharat Bhushan, James W. Schroeder, Kathleen R. Billings, Nicholas Giancola, Dana M. Thompson
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2019)
Article
Otorhinolaryngology
Kathleen R. Billings, Shaan N. Somani, Jennifer Lavin, Bharat Bhushan
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Jill N. D'Souza, Taher S. Valika, Bharat Bhushan, Jonathan B. Ida
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2020)
Article
Otorhinolaryngology
Elliot Y. Koo, Matthew T. Maksimoski, Monica M. Herron, Bharat Bhushan, Meredith A. Reynolds, Ben Z. Katz, Douglas R. Johnston, Jeffrey C. Rastatter, John Maddalozzo
Summary: NTM is an important cause of cervicofacial lymphadenitis and skin/soft tissue infections in children, with potential effects on salivary glands. Treatment guidelines are currently lacking, and surgical excision after pre-operative medical management appears to be safe and effective for NTM CFL involving the parotid gland. Further research on optimizing antimycobacterial treatment duration is needed.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Article
Clinical Neurology
Sarah Xu, Sujay Turakhia, Michael Miller, Douglas Johnston, John Maddalozzo, Dana Thompson, Irina Trosman, Michael Grandner, Stephen H. Sheldon, Vikas Ahluwalia, Bharat Bhushan
Summary: Obstructive sleep apnea (OSA) negatively impacts the health-related quality of life (HR-QoL) in pediatric patients, specifically in terms of physical function mobility. The study also found correlations between sleep time and the apnea-hypopnea index with physical function mobility. These findings provide important insights for understanding and intervening in the impact of OSA on the quality of life in children.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Otorhinolaryngology
Kathleen R. Billings, Bharat Bhushan, Rachel J. Berkowitz, Christine Stake, Jennifer Lavin
Summary: A postoperative day one phone call to families can help identify common concerns and complications after adenotonsillectomy, providing an opportunity for the clinical team to provide additional education and care instructions to caregivers.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Cell Biology
Daniel Frankel, Matthew Davies, Bharat Bhushan, Yavuz Kulaberoglu, Paulina Urriola-Munoz, Justine Bertrand-Michel, Melissa R. Pergande, Andrew A. Smith, Swapan Preet, Thomas J. Park, Michele Vendruscolo, Kenneth S. Rankin, Stephanie M. Cologna, Janet R. Kumita, Nicolas Cenac, Ewan St John Smith
Article
Otorhinolaryngology
John Maddalozzo, Douglas R. Johnston, Andre Isaac, Bharat Bhushan, Jeffrey C. Rastatter
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2019)