Article
Multidisciplinary Sciences
Mia Ogaard Monsted, Laurits Juulskov Holm, Karsten Buschard, Martin Haupt-Jorgensen
Summary: This study failed to replicate the previously observed diabetes alleviative effects of a maternal gluten-free diet in NOD mouse offspring, and could not further elucidate potential mechanisms.
Review
Nutrition & Dietetics
Valdemar Brimnes Ingemann Johansen, Knud Josefsen, Julie Christine Antvorskov
Summary: This study systematically reviewed the association between maternal dietary factors during gestation and the risk of developing type 1 diabetes and/or islet autoimmunity (IA) in offspring. The most investigated dietary factors were gluten, dietary advanced glycosylated end products (dAGEs), vitamin D, fatty acids, and iron. The results showed that prenatal exposure to a gluten-free environment and certain fatty acids and vitamin D had protective effects against IA development, while in utero exposure to iron and fat correlated with increased risks of IA.
Article
Endocrinology & Metabolism
Randi K. Johnson, Roy Tamura, Nicole Frank, Ulla Uusitalo, Jimin Yang, Sari Niinisto, Carin Andren Aronsson, Anette-G. Ziegler, William Hagopian, Marian Rewers, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris
Summary: The study found that maternal food consumption during late pregnancy was not significantly associated with offspring risk for IA or type 1 diabetes.
Article
Endocrinology & Metabolism
Georgiana Sitoris, Flora Veltri, Malika Ichiche, Pierre Kleynen, Jean-Philippe Praet, Serge Rozenberg, Kris G. Poppe
Summary: There is an association between thyroid autoimmunity and gestational diabetes mellitus in older euthyroid pregnant women. Consistent with previous literature, advanced age and high BMI are strongly associated with gestational diabetes mellitus.
EUROPEAN THYROID JOURNAL
(2022)
Review
Immunology
Susanna Esposito, Elena Mariotti Zani, Lisa Torelli, Sara Scavone, Maddalena Petraroli, Viviana Patianna, Barbara Predieri, Lorenzo Iughetti, Nicola Principi
Summary: Type 1 diabetes is the most common pediatric endocrine disease with an increased infection risk and lower immune response to vaccines; further research is needed to establish the most effective and safe vaccine use in this population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Yanhua Li, Tian Li, Zhiguang Zhou, Yang Xiao
Summary: Galectin-3, a member of the galectin family, plays a crucial role in inflammation, autoimmunity, apoptosis, and chemotaxis, and is widely expressed in immune cells. Clinical research has shown that Galectin-3 levels are closely associated with diabetes and its complications, suggesting its potential use as a predictor and biomarker. Furthermore, Galectin-3 represents a promising therapeutic target for the prevention and treatment of diabetes and its complications, particularly macrovascular and microvascular complications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Markus Mattila, Leena Hakola, Sari Niinisto, Heli Tapanainen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Suvi M. Virtanen
Summary: The study found no association between maternal intake of vitamin C or iron during pregnancy and the risk of offspring developing islet autoimmunity or type 1 diabetes.
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Summary: Studies have shown that iron intake may be associated with the risk of developing type 1 diabetes. This study found that individuals with high iron intake had a lower risk of developing type 1 diabetes compared to those with moderate iron intake.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed
Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Natalin J. Valeff, Maria S. Ventimiglia, Marcos Dibo, Udo R. Markert, Federico Jensen
Summary: B1 B cells, a distinct subpopulation of B cells, have been controversial in their role during pregnancy. This study revealed an expanded and proliferative splenic B1 B cell population in mice during pregnancy, accompanied by an immunoregulatory phenotype, suggesting their critical role in the intricate process of pregnancy tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Diana Caroline da Silva Bastos, Maria Izabel Chiamolera, Renata Elen Silva, Maria Do Carmo Borges de Souza, Roberto Azevedo Antunes, Marcelo Marinho Souza, Ana Cristina Allemand Mancebo, Patricia Cristina Fernandes Areas, Fernando M. Reis, Edson Guimaraes Lo Turco, Flavia Fonseca Bloise, Tania M. Ortiga-Carvalho
Summary: This study aimed to evaluate the metabolic profile of follicular fluid and antithyroid autoantibody levels in Hashimoto thyroiditis. The results showed that the metabolic profile of follicular fluid is altered in women with Hashimoto thyroiditis, suggesting a potential mechanistic explanation for the association of this disease with female infertility.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Randi K. Johnson, Amanda J. Ireton, Patrick M. Carry, Lauren A. Vanderlinden, Fran Dong, Alex Romero, David R. Johnson, Debashis Ghosh, Fan Yang, Brigitte Frohnert, Ivana V. Yang, Katerina Kechris, Marian Rewers, Jill M. Norris
Summary: This study examined the association between T1D family history and T1D risk mediated by methylation near the DLGAP2 gene. The results showed a significant interaction between T1D family history and methylation at DLGAP2 region CpGs on T1D risk. The increased risk of T1D for children with affected mothers compared to those with no family history was mediated through differences in methylation at two CpGs in the DLGAP2 region, while DNA methylation changes did not explain the increased risk for children with an affected father or sibling. Additionally, DNA methylation in the DLGAP2 region was associated with gene expression of nearby protein-coding genes.
PEDIATRIC DIABETES
(2023)
Article
Endocrinology & Metabolism
Francesca Orsolini, Elena Gianetti, Chiara Terrenzio, Lucia Montanelli, Elena Benelli, Brunella Bagattini, Emilio Fiore, Massimo Tonacchera
Summary: This study evaluated the role of thyroid autoantibodies in adverse pregnancy outcomes. The results showed that the presence and titer of thyroid autoantibodies do not have a negative impact on gestation if thyroid function is adequately controlled. Although not significant, suboptimal thyroid hormone status may have a greater impact on pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Rachel D'Amico, Djhenne Dalmacy, Jenifer A. Akinduro, Madison Hyer, Stephen Thung, Shengyi Mao, Naleef Fareed, Seuli Bose-Brill
Summary: Gestational diabetes (GD) affects pregnancy and increases the risk of type 2 diabetes. The study aimed to explore how often individuals with GD access primary care and type 2 diabetes screening.