Article
Nutrition & Dietetics
Rachel Strahm, Manuel Weber, Reiner Wiest, Kai-Uwe Schmitt
Summary: This study examined the effects of early tube feeding compared to tube feeding after 24 hours on clinical parameters. Patients with percutaneous endoscopic gastrostomy (PEG) received tube feeding 4 hours after tube insertion following the updated ESPEN guidelines. An observational study analyzed whether the new scheme affected patient complaints, complications, or hospitalization duration. The study found that the new scheme did not impact patient complaints or complications, but it significantly reduced hospitalization duration.
Article
Nutrition & Dietetics
Marcin Folwarski, Stanislaw Klek, Michal Brzezinski, Agnieszka Szlagatys-Sidorkiewicz, Adam Wyszomirski, Jaroslaw Meyer-Szary, Karolina Skonieczna-Zydecka
Summary: This study investigated the prevalence and epidemiology of percutaneous endoscopic gastrostomy (PEG) placements in Poland from 2010 to 2020. The results showed an increasing number of PEG placements, particularly in the elderly population. Malnutrition, dysphagia, and cardiorespiratory/metabolic diseases were the most common primary diseases. A significant percentage of patients diagnosed with cancer, specifically head and neck cancer (HNC) and esophageal cancer, had PEG. Approximately 27.6% of all PEG patients received home enteral nutrition (HEN). The study also found that regional disparities in PEG prevalence were influenced by factors such as the number of patients in nursing care facilities, lower education levels, and fewer hospital beds available.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ana Pinar-Gutierrez, Pilar Serrano-Aguayo, Silvia Garcia-Rey, Rocio Vazquez-Gutierrez, Irene Gonzalez-Navarro, Dolores Tatay-Dominguez, Pilar Garrancho-Dominguez, Pablo J. Remon-Ruiz, Antonio J. Martinez-Ortega, Veronica Nacarino-Mejias, Alvaro Iglesias-Lopez, Jose Luis Pereira-Cunill, Pedro Pablo Garcia-Luna
Summary: This study aimed to describe and compare the complications associated with different percutaneous radiologic gastrostomy (PRG) techniques. The results showed that the implementation of the balloon-type technique with gastropexy significantly reduced complications, and the most common complications were minor.
Article
Gastroenterology & Hepatology
Divyanshoo R. Kohli, Kevin F. Kennedy, Madhav Desai, Prateek Sharma
Summary: This study compared the safety and outcomes of three different techniques for performing a gastrostomy, and found that endoscopic placement of a gastrostomy tube (PEG) is associated with lower risks of inpatient adverse events, mortality, and readmission rates compared to fluoroscopy-guided gastrostomy and open surgical gastrostomy.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Health Care Sciences & Services
Xia Li, Jun-Xi Wang, Yu-Ping Wang, Jia-Xin Shen, Yi-Xing Zheng, Pei-Hong Zhang, Jing-Jing Wei, Ze-Hao Zhuang
Summary: This study compared indications, success rates, and complications of pull and introducer techniques for percutaneous endoscopic gastrostomy (PEG). The introducer technique was found to be more suitable for patients with esophageal stricture, with lower minor complications but a higher rate of tube replacement compared to the pull technique. The use of antibiotics may reduce minor complications following PEG, and early PEG insertion may help to reduce post-PEG major complications.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Review
Gastroenterology & Hepatology
Anand Rajan, Peerapol Wangrattanapranee, Jonathan Kessler, Trilokesh Dey Kidambi, James H. Tabibian
Summary: Gastrostomy tube placement is a procedure that provides enteral access for nutrition, decompression, and medication administration. Preprocedural evaluation and patient selection are necessary to reduce the risk of adverse events. Medical history, physical examination, and imaging should be considered to ensure the appropriate approach and safety of the procedure.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Nutrition & Dietetics
James Evans, Dan Green, Graeme O. Connor, Julie Lanigan, Faith Gibson
Summary: This study investigated nutrition support practices in pediatric allogeneic BMT centers and compared clinicians' opinions on gastrostomy use. The results showed that there was a similar approach to nutritional support in many aspects. The use of gastrostomy divided opinions among clinicians, but there was agreement on potential complications.
Article
Gastroenterology & Hepatology
Vitor Macedo Silva, Marta Freitas, Rui Sousa Magalhaes, Tiago Curdia Goncalves, Pedro Boal Carvalho, Carla Marinho, Jose Cotter
Summary: This study aimed to evaluate the diameter or length variations of gastrostomy buttons within the first year of placement and identify potential factors associated with these variations. The findings showed that diameter variations were more frequent in patients living in nursing homes, those with previous PEG tube dislodgement, and male patients. Length variations occurred more frequently in patients with significant weight changes during the follow-up period.
DIGESTIVE DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Segger, Timo A. Auer, Florian Nima Fleckenstein, Uli Fehrenbach, Giovanni Federico Torsello, Anne Frisch, Martin Jonczyk, Bernd Hamm, Bernhard Gebauer
Summary: The study found that CT-PG has a high success rate with low complication rates in both trocar and Seldinger groups. For patients with ascites, CT-PG remains safe if paracentesis is performed beforehand.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Nutrition & Dietetics
Deanna Emmons
Summary: The multidisciplinary education protocol for gastrostomy tube (GT) use and care effectively reduced complications postplacement, demonstrating the importance of patient education in reducing adverse events.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Nutrition & Dietetics
Thane Blinman, Dennis Hiller
Summary: This article discusses the benefits and hazards of gastrostomy tubes, highlighting the enormous time and effort costs involved in managing them. Despite their widespread use and high costs, there is a lack of practical guidance for addressing tube-related problems, leading clinicians to rely on folklore or ineffective work-arounds. The aim of this article is to demystify these devices and dispel misconceptions.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Medicine, Research & Experimental
Miroslav Vujasinovic, Elin Marsk, Apostolos Tsolakis, Boel Hynning, Martin Nordberg, Mats Lindblad, Catarina Lindqvist, Lalle H. Nordenvall, Rusana Bark, Peter Elbe
Summary: This study aimed to determine the complication rates after percutaneous endoscopic gastrostomy (PEG) and open gastrostomy (OG) in patients with head and neck cancers (HNCs). The results showed that enteral feeding via gastrostomy is a safe method, regardless of the technique used (PEG or OG), with a low rate of major complications and no mortality linked to the procedure.
Article
Food Science & Technology
Kenji Horie, Md. Saddam Hossain, Yugweng Kim, Ishida Akiko, Ryoko Kon, Atsushi Yamatsu, Masako Kishima, Toshio Nishikimi, Mujo Kim
Summary: The study demonstrated that Banafine(R) administration significantly increased antibody levels in elderly bedridden patients following influenza vaccination, suggesting a potential modulation of immune function in the elderly population.
JOURNAL OF FOOD SCIENCE
(2021)
Review
Pediatrics
Loren Berman, Robert Baird, Ana Sant'Anna, Rachel Rosen, Maria Petrini, Michael Cellucci, Lynn Fuchs, Joanna Costa, Jennifer Lester, Jenny Stevens, Michele Morrow, Danielle Jaszczyszyn, Joao Amaral, Adam Goldin
Summary: Despite variability in preoperative work-up and procedural technique of gastrostomy placement in children, there is a lack of literature on patient-centric outcomes. This review provides consensus-driven guidelines based on existing literature to guide decision-making throughout the enteral access process for children.
Article
Otorhinolaryngology
Claudio Sampieri, Andrea Costantino, Giorgio Gregory Giordano, Michael Dale, Filippo Marchi, Andrea Iandelli, Marta Filauro, Giampiero Parrinello, Gian Marco Pace, Bianca Maria Festa, Giuseppe Spriano, Armando De Virgilio, Giorgio Peretti
Summary: The study developed a prediction model using a scoring system and nomogram to predict the necessity of enteral nutrition for head and neck surgery patients at 28 days postoperatively. The model showed high prediction performances and can guide the development of personalized nutrition protocols.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Gastroenterology & Hepatology
Alessandro Vitale, Gianluca Svegliati-Baroni, Alessio Ortolani, Monica Cucco, Giulio Dalla Riva, Edoardo G. Giannini, Fabio Piscaglia, Gianludovico Rapaccini, Mariella Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Giuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Antonio Gasbarrini, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Filippo Oliveri, Filippo Pelizzaro, Rafael Ramirez Morales, Umberto Cillo, Franco Trevisani, Luca Miele, Giulio Marchesini, Fabio Farinati
Summary: This study compared patients with MAFLD and non-MAFLD who had hepatocellular carcinoma (HCC) in Italy. It found that the proportion of MAFLD in HCC patients was increasing over time and is expected to surpass non-MAFLD in the future. Despite a later cancer stage at diagnosis, MAFLD HCC patients had a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Article
Medicine, General & Internal
Quirino Lai, Nicoletta De Matthaeis, Michele Finotti, Giovanni Galati, Giuseppe Marrone, Fabio Melandro, Filomena Morisco, Daniele Nicolini, Riccardo Pravisani, Edoardo G. Giannini
Summary: This study evaluates the impact of antiplatelet therapy on the incidence and mortality of hepatocellular carcinoma. The results suggest that antiplatelet therapy is associated with a reduced risk of HCC incidence and post-treatment mortality.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Gastroenterology & Hepatology
Stefano Kayali, Andrea Pasta, Maria Corina Plaz Torres, Ariel Jaffe, Mario Strazzabosco, Simona Marenco, Edoardo G. Giannini
Summary: This systematic review with pooled analysis assessed the safety and efficacy of immune checkpoint inhibitor (ICI) therapy in liver transplant recipients. The results showed that ICI treatment in these patients is associated with a risk of graft rejection and mortality, but some patients had disease control and longer overall survival. More prospective studies are needed to provide accurate data on the safety and efficacy of ICI treatment in this population.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Rodolfo Sacco, Daryl Ramai, Raffaella Tortora, Giovan Giuseppe di Costanzo, Michela Emma Burlone, Mario Pirisi, Piera Federico, Bruno Daniele, Marianna Silletta, Paolo Gallo, Caterina Cocuzza, Maurizio Russello, Giuseppe Cabibbo, Gabriele Rancatore, Silvia Cesario, Gianluca Masi, Luca Marzi, Andrea Mega, Alessandro Granito, Giulia Pieri, Edoardo G. G. Giannini, Rosa Paolillo, Gennaro Gadaleta-Caldarola, Vincenzo Dadduzio, Guido Giordano, Luca Giacomelli, Simonetta Papa, Matteo Renzulli, Marcello Maida, Michele Ghidini, Mauro Borzio, Antonio Facciorusso
Summary: Hepatocellular carcinoma is the fifth most common cancer worldwide. Lenvatinib has proven to be an effective option for treating advanced diseases. Our study showed that patients with nonviral etiologies have longer survival than those with viral etiology, which is important for clinical decision-making.
Review
Gastroenterology & Hepatology
Andrea Pasta, Francesco Calabrese, Sara Labanca, Simona Marenco, Giulia Pieri, Maria Corina Plaz Torres, Nicolas M. Intagliata, Stephen H. Caldwell, Edoardo G. Giannini
Summary: This study aimed to assess the safety and efficacy of venous thromboembolism (VTE) prophylaxis in patients with cirrhosis. The results suggested that the current evidence is insufficient to advise for or against the use of VTE prophylaxis, mainly due to lack of quality and homogeneity of available data. However, the prophylaxis does not appear to be associated with a significant bleeding risk.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Edoardo G. Giannini, Giacomo Borgonovo, Simona Marenco, Manuela Cesaretti
LIVER TRANSPLANTATION
(2023)
Letter
Hematology
Andrea Pasta, Francesco Calabrese, Edoardo G. Giannini
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Simone Caprioli, Giorgio-Gregory Giordano, Alessia Pennacchi, Valentina Campagnari, Andrea Iandelli, Giampiero Parrinello, Cristina Conforti, Riccardo Gili, Edoardo Giannini, Elisa Marabotto, Stefano Kayali, Bernardo Bianchi, Giorgio Peretti, Giuseppe Cittadini, Filippo Marchi
Summary: This study evaluates the potential of high-frequency intraoral ultrasonography (IOUS) in predicting histological risk factors in oral cavity squamous cell carcinoma (OSCC). The results show excellent agreement between ultrasonographic and pathological measurements of depth of invasion (DOI), and a significant association between ultrasonographic morphology and adverse histopathological factors. IOUS demonstrates high sensitivity and specificity in predicting Brandwein-Gensler score.
Editorial Material
Oncology
Stefano Kayali, Elisa Marabotto, Edoardo Giannini
Review
Pharmacology & Pharmacy
Diego Bagnasco, Edoardo Vincenzo Savarino, Mona-Rita Yacoub, Fulvio Braido, Maria Giulia Candeliere, Edoardo Giannini, Giovanni Passalacqua, Elisa Marabotto
Summary: Type 2 inflammation plays a crucial role in various diseases, and drugs originally developed for severe asthma have shown potential in treating eosinophilic esophagitis. Promising results from clinical trials suggest that these drugs may also be used in gastroenterology in the future.
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Article
Rheumatology
Ylenia Marten Canavesio, Andrea Pasta, Francesco Calabrese, Elisa Alessandri, Maurizio Cutolo, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vincenzo Savarino, Edoardo Giovanni Giannini, Patrizia Zentilin, Giorgia Bodini, Manuele Furnari, Edoardo Savarino, Elisa Marabotto
Summary: This study aims to evaluate the association and prognostic implication between motor esophageal disorders and pulmonary involvement in SSc patients. The study found that the severity of motor esophageal disorders is positively correlated with the severity of pulmonary disease.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Arshad M. Muhammad, Mohammed F. Farooqi, Mohamed M. Bashir, Aysha S. Aldhaheri, Adnan Agha
Summary: Hypothyroidism is a common endocrine condition with a wide range of symptoms, including dysphagia. The underlying mechanism of dysphagia in hypothyroidism is still unknown, but it is believed to be related to hormonal effects on esophageal and gastric motility. It is important for practitioners to consider hypothyroidism as a possible cause of dysphagia after ruling out other obstructive pathologies.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Letter
Medicine, General & Internal
Edoardo G. Giannini, Tommaso Testa, Federica Grillo, Luca Mastracci, Serena Arrigo, Piero Cai, Sabrina Paolino, Martina Burlando, Livia Pisciotta, Elena Formisano, Giuseppe Cittadini, Francesco Copello, Sabrina Tuo, Giorgia Bodini
Summary: The establishment of an interdisciplinary IBD center is associated with improved healthcare utilization, including a decrease in hospitalizations per patient/year, a decrease in length of hospitalization, and an increase in patients on biologics.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Giorgia Bodini, Elisabetta Giuliana, Irene Giberti, Giulia Guarona, Federica Benvenuto, Elisa Ferretti, Maria Giulia Demarzo, Giorgio Da Rin, Giancarlo Icardi, Edoardo G. Giannini
Summary: The antibody response to COVID-19 vaccination in patients with inflammatory bowel disease (IBD) on biological drugs is optimal, regardless of the mechanism of action. Patients treated with anti-TNF seem to have an earlier response to vaccination, while concomitant low-dose corticosteroids and disease activity do not appear to affect the response.
GASTROINTESTINAL DISORDERS
(2022)