Journal
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Volume 67, Issue 1, Pages 73-81Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/01635581.2015.965333
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Funding
- NIH [RO1 CA120381, P30 CA130810 S1]
- Cancer Center Support Grant [P30 CA046592]
- Clinical Translational Science Award, NIH [UL1RR024986]
- Michigan Diabetes Research and Training Center NIH [5P60 DK20572]
- Michigan Nutrition and Obesity Research Center NIH [P30 DK089503]
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The available evidence indicates that gamma-tocopherol has more potential for colon cancer prevention than alpha-tocopherol, but little is known about the effects of foods and supplements on tocopherol levels in human colon. This study randomized 120 subjects at increased colon cancer risk to either a Mediterranean or a Healthy Eating diet for 6 mo. Supplement use was reported by 39% of the subjects, and vitamin E intake from supplements was twofold higher than that from foods. Serum alpha-tocopherol at baseline was positively predicted by dietary intakes of synthetic vitamin E in foods and supplements but not by natural alpha-tocopherol from foods. For serum gamma-tocopherol, dietary gamma-tocopherol was not a predictor, but dietary alpha-tocopherol was a negative predictor. Unlike with serum, the data supported a role for metabolic factors, and not a direct effect of diet, in governing concentrations of both alpha- and gamma-tocopherol in colon. The Mediterranean intervention increased intakes of natural alpha-tocopherol, which is high in nuts, and decreased intakes of gamma-tocopherol, which is low in olive oil. These dietary changes had no significant effects on colon tocopherols. The impact of diet on colon tocopherols therefore appears to be limited.
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