Article
Environmental Sciences
Hiroaki Itoh, Kouji H. Harada, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Kazuhito Yokoyama, Jing Zhu, Mariko Harada Sassa, Shoichiro Tsugane, Motoki Iwasaki
Summary: The study did not find an overall association between serum PFAS concentrations and an increased risk of breast cancer; instead, many inverse associations between serum PFAS concentrations and breast cancer risk were discovered.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Kyoko Kondo, Kanzo Suzuki, Masakazu Washio, Satoko Ohfuji, Satoru Adachi, Sakae Kan, Seiichiro Imai, Kunihiko Yoshimura, Naoyuki Miyashita, Nobumitsu Fujisawa, Akiko Maeda, Wakaba Fukushima, Yoshio Hirota
Summary: A large prospective cohort study in the United States found an inverse association between pneumonia and influenza deaths and coffee intake. In Japan, where the mortality rate of pneumonia in elderly people is high, a hospital-based case control study investigated the association between coffee and green tea intake and pneumonia among the elderly. The study suggested a preventive association between coffee intake over 2 cups per day and pneumonia in the elderly.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yichi Chen, Sarah K. Abe, Manami Inoue, Taiki Yamaji, Motoki Iwasaki, Shuhei Nomura, Masahiro Hashizume, Shoichiro Tsugane, Norie Sawada
Summary: This study used data from a large prospective cohort study in Japan to evaluate the association between green tea and coffee consumption and the risk of kidney cancer. The study found no significant association between green tea intake and kidney cancer risk in the total population. However, among women who consumed more than five cups of green tea per day, a significantly decreased risk was observed. The association between coffee consumption and kidney cancer risk was not statistically significant.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nobuhiro Narii, Kumiko Kito, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Yasuto Matsui, Tomonari Matsuda, Ayaka Kotemori, Misako Nakadate, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane, Junko Ishihara, Norie Sawada
Summary: In this nested case-control study, no association was observed between acrylamide (AA) and glycidamide (GA) hemoglobin adducts (HbAA and HbGA) and breast cancer, except for a positive association between the HbGA/HbAA ratio and breast cancer. The risk of breast cancer associated with acrylamide may need to be evaluated by considering not only the absolute amount of HbAA or HbGA but also the HbGA/HbAA ratio and the activity of metabolic genes.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Multidisciplinary Sciences
Somaye Rigi, Seyed Mohammad Mousavi, Sanaz Benisi-Kohansal, Leila Azadbakht, Ahmad Esmaillzadeh
Summary: Higher adherence to a plant-based diet index and a hypothesized healthful plant-based diet index was associated with a lower risk of breast cancer, while adherence to an unhealthful version of a plant-based diet index was linked to a higher risk.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fatemeh Hosseini, Sakineh Shab-Bidar, Mahtab Ghanbari, Maryam Majdi, Fatemeh Sheikhhossein, Hossein Imani
Summary: Adherence to food quality score (FQS) may be associated with an increased risk of breast cancer in overall and premenopausal women, but no association was observed in postmenopausal women. Prospective cohort studies are needed to confirm these findings.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Elodie Jobard, Laure Dossus, Laura Baglietto, Marco Fornili, Lucie Lecuyer, Francesca Romana Mancini, Marc J. Gunter, Olivier Tredan, Marie-Christine Boutron-Ruault, Benedicte Elena-Herrmann, Gianluca Severi, Joseph A. Rothwell
Summary: Perturbations in circulating metabolites were observed in premenopausal but not postmenopausal breast cancer cases. Metabolites such as histidine, N-acetyl glycoproteins, glycerol, and ethanol were associated with breast cancer risk, particularly in the premenopausal subgroup.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Jihye Choi, Tae-Woong Ha, Hye-Mi Choi, Han-Byoel Lee, Hee-Chul Shin, Woosung Chung, Wonshik Han
Summary: A breast cancer prediction model for Korean women was developed using published polygenic risk scores (PRS) combined with nongenetic risk factors (NGRF). The study found that the combined Asian and European PRSs were predictive of breast cancer in Korean women, supporting the use of these models for personalized screening and prevention.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Environmental Sciences
Milena Andelkovic, Aleksandra Buha Djordjevic, Evica Antonijevic Miljakovic, Dragana Javorac, Natasa Colakovic, Svetlana Opric, Simona Petricevic, Miroslav Granic, Jelena Kotur-Stevuljevic, Biljana Antonijevic, Zorica Bulat
Summary: Breast cancer is strongly associated with factors such as gender, age, hormone therapy, smoking, exposure to endocrine disruptors, and family history. This study found significantly higher cadmium concentration in tumor tissue of breast cancer patients compared to healthy tissue, indicating a potential link between cadmium exposure and cancer development. Additionally, the study highlighted the role of oxidative stress as a critical mechanism in cadmium toxicity and its implications in breast cancer onset.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Emma Fontvieille, Mathilde His, Carine Biessy, Anne-Sophie Navionis, Gabriela Torres-Mejia, Angelica Angeles-Llerenas, Isabel Alvarado-Cabrero, Gloria Ines Sanchez, Edgar Navarro, Yorlany Rodas Cortes, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, Jose Luis Soto, Leonor Moyano, Peggy L. Porter, Ming Gang Lin, Jamie Guenthoer, Isabelle Romieu, Sabina Rinaldi
Summary: This study supports the association between chronic inflammation and breast cancer risk in young women in Latin America. Larger prospective studies are needed to confirm these findings in premenopausal women.
Article
Nutrition & Dietetics
Kexin Tu, Kaiyan Liu, Yifan Wang, Yiling Jiang, Caixia Zhang
Summary: This study aimed to investigate the relationship between dietary Zinc (Zn), Selenium (Se) intake and breast cancer risk in Chinese women. The results showed that Zn intake from white meat was inversely associated with breast cancer risk, while Se intake from red meat was positively associated with breast cancer risk. In conclusion, dietary Zn and Se intake were associated with breast cancer risk in Chinese women, and optimal zinc intake may be beneficial for breast cancer prevention.
Article
Oncology
Toshifumi Namba, Naoko Matsuda, Mahbubur Rahman, Naoki Kanomata, Hideko Yamauchi, Hiroko Tsunoda
Summary: This study compared the risk of developing breast cancer between women with dense breasts and non-dense breasts. It found that dense breasts at baseline are a risk factor for breast cancer development in Japanese women, especially in those aged 50 years or younger.
Article
Multidisciplinary Sciences
Kota Fukai, Yuko Furuya, Shoko Nakazawa, Noriko Kojimahara, Keika Hoshi, Akihiro Toyota, Masayuki Tatemichi
Summary: This study investigated the risks of cardiovascular diseases associated with specific occupations using a nation-wide, multicentre, hospital-based registry data. The analysis found that different occupations were associated with different risks of cardiovascular diseases in men and women, suggesting that the risk may vary by occupation. The study highlights the importance of considering occupational factors in assessing cardiovascular disease risks.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Yurii B. Shvetsov, Lynne R. Wilkens, Kami K. White, Marie Chong, Arielle Buyum, Grazyna Badowski, Rachael T. Leon Guerrero, Rachel Novotny
Summary: This study aimed to develop a breast cancer risk prediction model for Chamorro and Filipino women in the Mariana Islands and compared its performance to that of the Breast Cancer Risk Assessment Tool (BCRAT). The study found that the ability to develop breast cancer risk models for Mariana Islands women is constrained by the small population size and limited availability of health services and data. However, it demonstrated that breast cancer risk prediction models with adequate discriminatory performance can still be built for small populations like in the Mariana Islands.
Article
Biochemistry & Molecular Biology
Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia N. Antonenkova, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Marinus J. Blok, Natalia Bogdanova, Bernardo Bonanni, Barbara Burwinkel, Nicola J. Camp, Archie Campbell, Jose E. Castelao, Melissa H. Cessna, Stephen J. Chanock, Kamila Czene, Peter Devilee, Thilo Doerk, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anna Gonzalez-Neira, Felix Grassmann, Pascal Guenel, Melanie Gundert, Andreas Hadjisavvas, Eric Hahnen, Per Hall, Ute Hamann, Patricia A. Harrington, Wei He, Peter Hillemanns, Antoinette Hollestelle, Maartje J. Hooning, Reiner Hoppe, Anthony Howell, Keith Humphreys, Agnes Jager, Anna Jakubowska, Elza K. Khusnutdinova, Yon-Dschun Ko, Vessela N. Kristensen, Annika Lindblom, Jolanta Lissowska, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, William G. Newman, Nadia Obi, Mihalis Panayiotidis, Muhammad U. Rashid, Valerie Rhenius, Matti A. Rookus, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Mitul Shah, Reijo Sironen, Melissa C. Southey, Maija Suvanto, Rob A. E. M. Tollenaar, Ian Tomlinson, Therese Truong, Lizet E. van der Kolk, Elke M. van Veen, Barbara Wappenschmidt, Xiaohong R. Yang, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Michael Lush, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Muriel A. Adank, Marjanka K. Schmidt, Irene L. Andrulis, Jenny Chang-Claude, Heli Nevanlinna, Georgia Chenevix-Trench, D. Gareth Evans, Roger L. Milne, Paolo Radice, Paolo Peterlongo
Summary: Evidence from the BRIDGES study suggests that germline protein truncating variants (PTVs) in FANCM are associated with increased risk of ER-negative and triple-negative breast cancer (TNBC), particularly for those with a family history. This study further investigates the association between FANCM missense variants (MVs) and breast cancer risk using the BRIDGES study, analyzing a total of 689 MVs. The results indicate that FANCM MVs may be low/moderate risk factors for ER-negative and TNBC subtypes of breast cancer.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Nutrition & Dietetics
Miyuki Hori, Norie Sawada, Kumiko Kito, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: This study aimed to investigate the associations between vegetable and fruit intake and CRC risk by smoking status.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Paramita Khairan, Tomotaka Sobue, Ehab Salah Eshak, Tetsuhisa Kitamura, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada
Summary: This study aimed to investigate the association between consumption of sugary drinks and gastric cancer (GC) risk in a Japanese population. The study found no association between sugary drink consumption and GC risk.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Oncology
Tetsuro Toriumi, Masanori Terashima, Junki Mizusawa, Yuya Sato, Yukinori Kurokawa, Shuji Takiguchi, Yuichiro Doki, Hisashi Shinohara, Shin Teshima, Takushi Yasuda, Seiji Ito, Takaki Yoshikawa, Takeshi Sano, Mitsuru Sasako
Summary: Recurrence patterns after curative gastrectomy were studied, and clinicopathological characteristics associated with each type of recurrence were determined. Understanding these patterns can help with early detection and personalized follow-up plans.
Article
Public, Environmental & Occupational Health
Kenta Tanaka, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane
Summary: This study analyzed data from 30,381 middle-aged Japanese adults and found that fecal occult blood test (FOBT) and colonoscopy both reduced the risk of death and incidence of colorectal cancer (CRC).
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Masato Ozaka, Kohei Nakachi, Satoshi Kobayashi, Akihiro Ohba, Hiroshi Imaoka, Takeshi Terashima, Hiroshi Ishii, Junki Mizusawa, Hiroshi Katayama, Tomoko Kataoka, Takuji Okusaka, Masafumi Ikeda, Naoki Sasahira, Haruo Miwa, Eishiro Mizukoshi, Naohiro Okano, Nobumasa Mizuno, Tomohisa Yamamoto, Yoshito Komatsu, Akiko Todaka, Ken Kamata, Masayuki Furukawa, Nao Fujimori, Akio Katanuma, Yukiko Takayama, Hidetaka Tsumura, Haruhiko Fukuda, Makoto Ueno, Junji Furuse
Summary: The aim of this study was to compare the efficacy of mFOLFIRINOX with that of GnP for LAPC. The results showed that GnP had better response rate, CA19-9 response, and mild gastrointestinal toxicities, making it a candidate for a subsequent phase III trial.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Yoshinori Ito, Tetsuya Hamaguchi, Atsuo Takashima, Junki Mizusawa, Yasuhiro Shimada, Manabu Shiozawa, Nobutaka Mizoguchi, Takeshi Kodaira, Koji Komori, Masayuki Ohue, Koji Konishi, Fuminori Teraishi, Makoto Kinouchi, Kohei Murata, Fumihiko Fujita, Masahiko Watanabe, Gen Iinuma, Fumio Ishida, Yoshihisa Saida, Takahisa Matsuda, Hiroshi Katayama, Haruhiko Fukuda, Yukihide Kanemitsu, Japan Clinical Oncology Grp
Summary: This study evaluated the efficacy and safety of S-1 plus mitomycin-C chemoradiotherapy for locally advanced squamous cell carcinoma of the anal canal. It determined the recommended dose and found that it had an acceptable toxicity profile and favorable 3-year survival, making it a treatment option.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Mathematical & Computational Biology
Kanako Fuyama, Mitsunori Ogawa, Junki Mizusawa, Yukihide Kanemitsu, Shin Fujita, Takuya Kawahara, Kentaro Sakamaki, Koji Oba
Summary: This study examined the impact of correlations between variables on the net benefit values and estimates in clinical trials. The results showed that the correlations could affect the net benefit in either a positive or negative direction, and a corrective method was proposed to mitigate this bias.
STATISTICS IN MEDICINE
(2023)
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Oncology
Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Manolis Kogevinas, Jose Maria Huerta, Jesus Vioque, Manoli Garcia de la Hera, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Zuo-Feng Zhang, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Carlo La Vecchia, Paolo Boffetta
Summary: The association between sleep duration and stress with gastric cancer (GC) was examined. Long sleep duration (=9 h) was found to be associated with GC, while stress was associated with noncardia GC.
Article
Public, Environmental & Occupational Health
Hiroshi Yatsuya, Kazumasa Yamagishi, Yuanying Li, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Manami Inoue, Shoichiro Tsugane, Hiroyasu Iso, Norie Sawada
Summary: This study examined the associations of major risk factors for stroke with different types of stroke and subtypes of ischemic stroke. The results showed that hypertension is the most crucial risk factor for stroke prevention in Japan.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Juan Xu, Atsushi Goto, Maki Konishi, Masayuki Kato, Tetsuya Mizoue, Yasuo Terauchi, Shoichiro Tsugane, Norie Sawada, Mitsuhiko Noda
Summary: This study aimed to develop and validate models to predict the 5-year incidence of T2DM in a Japanese population. The risk scores were developed using data from two different cohorts, and both non-invasive and invasive predictors were considered. The invasive model with HbA1c and FPG showed the highest discriminative ability.
JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Oncology
Hiroto Ishiki, Yuichiro Kikawa, Mitsumi Terada, Junki Mizusawa, Michitaka Honda, Tsuguo Iwatani, Tomonori Mizutani, Keita Mori, Naoki Nakamura, Tempei Miyaji, Takuhiro Yamaguchi, Masahiko Ando, Kenichi Nakamura, Haruhiko Fukuda, Naomi Kiyota
Summary: Assessing patient-reported outcomes and health-related quality of life in cancer clinical trials has become increasingly important due to the promotion of patient and public involvement in cancer treatment development. The Japan Clinical Oncology Group has seen growing demand for such assessments, but standardized methods for analyzing and interpreting the results are still lacking. To address this issue, the Japan Clinical Oncology Group has reorganized its patient-reported outcome/quality of life research committee and revised its research policy to promote the inclusion of patient-reported outcomes in future trials.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Correction
Oncology
Kazuhiko Mishima, Ryo Nishikawa, Yoshitaka Narita, Junki Mizusawa, Minako Sumi, Tomoyuki Koga, Nobuyoshi Sasaki, Manabu Kinoshita, Motoo Nagane, Yoshiki Arakawa, Koji Yoshimoto, Ichiyo Shibahara, Naoki Shinojima, Kenichiro Asano, Takao Tsurubuchi, Hikaru Sasaki, Akio Asai, Takashi Sasayama, Yasutomo Momii, Atsushi Sasaki, Shigeo Nakamura, Masaru Kojima, Jun-ichi Tamaru, Kazuhiro Tsuchiya, Miho Gomyo, Kayoko Abe, Manabu Natsumeda, Fumiyuki Yamasaki, Hiroshi Katayama, Haruhiko Fukuda
Article
Oncology
Junki Mizusawa, Masanori Tokunaga, Nozomu Machida, Hiroshi Yabusaki, Ryohei Kawabata, Hiroshi Imamura, Takahiro Kinoshita, Takashi Nomura, Souya Nunobe, Kunihiro Tsuji, Hiroshi Katayama, Haruhiko Fukuda, Narikazu Boku, Takaki Yoshikawa, Masanori Terashima
Summary: This study aims to investigate the difference in overall survival between preoperative chemotherapy with S-1 plus oxaliplatin followed by D2 gastrectomy and D2 gastrectomy with postoperative chemotherapy only in patients with clinical T3-4N1-3 M0 locally advanced gastric cancer.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Junki Mizusawa, Akihiro Ohba, Masato Ozaka, Hiroshi Katayama, Takuji Okusaka, Satoshi Kobayashi, Masafumi Ikeda, Takeshi Terashima, Naoki Sasahira, Naohiro Okano, Ikuya Miki, Takashi Kaneko, Nobumasa Mizuno, Akiko Todaka, Masayuki Furukawa, Shinya Kajiura, Tomoko Kataoka, Haruhiko Fukuda, Junji Furuse, Makoto Ueno
Summary: Gemcitabine plus nab-paclitaxel and combination chemotherapy with fluorouracil, leucovorin, irinotecan and oxaliplatin are standard treatments for metastatic or recurrent pancreatic cancer. Recent studies have shown promising results for modified fluorouracil, leucovorin, irinotecan and oxaliplatin and S-1, irinotecan and oxaliplatin.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)