Article
Biochemistry & Molecular Biology
Miao-Fen Chen, Yu-Yen Chen, Wen-Cheng Chen, Ching-Chuan Hsieh
Summary: Malnutrition is associated with reduced survival and deficient anticancer immunity in head and neck cancer patients. This study evaluated the relationship between nutritional status and immunologic factors, and its prognostic value for HNC. The results showed that malnutrition was significantly associated with advanced disease, lower BMI, lower RT completion rates, and reduced survival.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, General & Internal
Yuhong Li, Shijun Tong, Xueyuan Hu, Yuanjun Wang, Ronghua Lv, Shaozheng Ai, Ming Hou, Haining Fan, Youlu Shen
Summary: Maintaining good nutritional status is important for improving immune function and prognosis in COVID-19 patients, and poor nutritional status may be associated with disease severity and prognosis.
Article
Oncology
Giovanni D'Arena, Candida Vitale, Marta Coscia, Daniela Lamorte, Giuseppe Pietrantuono, Francesca Perutelli, Fiorella D'Auria, Teodora Statuto, Luciana Valvano, Annamaria Tomasso, Valentina Griggio, Rebecca Jones, Giovanna Mansueto, Oreste Villani, Simona D'Agostino, Vito Viglioglia, Vincenzo De Feo, Fabrizio Calapai, Carmen Mannucci, Alessandro Sgambato, Dimitar G. Efremov, Luca Laurenti
Summary: This study found that higher baseline serum levels of soluble CD200 in patients with chronic lymphocytic leukemia (CLL) were associated with more aggressive features and a worse prognosis. While soluble CD200 could predict a worse prognosis and response to chemotherapy, it did not have a significant impact on overall survival in multivariate analysis. The findings support the role of CD200 as a diagnostic tool, prognostic indicator, and potential therapeutic target in CLL.
Article
Clinical Neurology
Maelys Teng, Djamel Bensmail, Mouna Hanachi, Rebecca Haddad, Caroline Hugeron, Thibaud Lansaman, Jonathan Levy
Summary: This study aims to describe the nutritional status of patients with advanced-stage multiple sclerosis (MS). The study found that malnutrition is common in these patients and is associated with disease severity, MS subtype, and swallowing disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Oncology
Busra Gul, Selma Metintas, Guntulu Ak, Senay Yilmaz, Muzaffer Metintas
Summary: The study aimed to identify factors related to poor nutritional status and its impact on the prognosis of patients with locally advanced and advanced stage lung cancer. Poor nutritional status was associated with age, gender, performance status, and BMI for NSCLC, and performance status for SCLC. Poor nutritional status significantly decreased overall survival in both NSCLC and SCLC populations.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Nutrition & Dietetics
Arnav Mehta, Lorenzo De Paola, Tiberiu A. Pana, Ben Carter, Roy L. Soiza, Mohannad W. Kafri, John F. Potter, Mamas A. Mamas, Phyo K. Myint
Summary: This study systematically reviewed several prospective cohort studies and found that the nutritional status of stroke patients is associated with their outcomes. Underweight and low serum albumin levels increase the risk of death, while overweight and obesity reduce the risk of death.
Article
Nutrition & Dietetics
Miao-Fen Chen, Ching-Chuan Hsieh, Ping-Tsung Chen, Ming-Shian Lu
Summary: Malnutrition is associated with poor prognosis in esophageal-SCC patients, and nutritional status evaluated by PGSGA may be useful to guide treatment decisions in clinical practice. Nutritional supplementation is suggested to improve prognosis, and it might be related to augmented anticancer immune response.
Article
Multidisciplinary Sciences
Qi Xiao, Xiaoqing Li, Baojun Duan, Xiaofan Li, Sida Liu, Boyu Xu, Shuai Shi, Jin Zhang, Haoyuan Qin, Xianglong Duan, Yansong Pu
Summary: The stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. This study found that the CONUT score is related to postoperative complications, psychological status, and quality of life in patients with gastric cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yaning He, Yingbo Shao, Qi Chen, Chaojun Liu, Fangyuan Zhu, Hui Liu
Summary: This study retrospectively analyzed the clinical and survival information of de novo stage IV breast cancer patients with brain metastasis (BM) using the SEER database. The incidence and prognosis of BM were found to be closely associated with subtype and metastatic burden, which may help in developing diagnostic strategies.
Article
Endocrinology & Metabolism
Takayoshi Akimoto, Makoto Hara, Akihiko Morita, Shuichiro Uehara, Hideto Nakajima
Summary: This study found a significant correlation between UNR-GNRI and UND-CONUT scores after acute ischemic stroke. The presence of undernutrition based on UND-CONUT scores was associated with poor prognosis after AIS.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Oncology
Aneta Jachnis, Maciej Tomasz Slodkowski
Summary: Recent studies have obtained inadequate data on the association between nutritional status, body composition, clinical parameters and tumor stage in patients with pancreatic and periampullary tumors. The study assessed the relationship between nutritional status, body composition, and selected clinical parameters in patients with pancreatic and periampullary cancer, as well as described differences between resection and non-resection groups.
Article
Multidisciplinary Sciences
Francesco Vladimiro Segala, Emanuele Rando, Federica J. Salvati, Marcantonio Negri, Francesca Catania, Flavia Sanmartin, Rita Murri, Evangelos Giamarellos-Bourboulis, Massimo Fantoni
Summary: A retrospective cohort study found that early administration of anakinra, an interleukin-1 receptor antagonist, guided by baseline suPAR levels, can prevent disease progression and death in COVID-19 patients. In the absence of suPAR testing, the SCOPE score can be used as an alternative for treatment decisions.
Article
Health Care Sciences & Services
Vanitha Krishnan, Rafdzah Ahmad Zaki, Azmi Mohamed Nahar, Muhammad Yazid Jalaludin, Hazreen Abdul Majid
Summary: The study revealed an increasing trend of anaemia prevalence among Malaysian adolescents, particularly more common in females. Not meeting the Recommended Nutrient Intake (RNI) for total iron intake per day showed a significant association with anaemia and iron deficiency anaemia.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Oncology
Marie Metairie, Louise Benoit, Meriem Koual, Enrica Bentivegna, Henri Wohrer, Pierre-Adrien Bolze, Yohan Kerbage, Emilie Raimond, Cherif Akladios, Xavier Carcopino, Geoffroy Canlorbe, Jennifer Uzan, Vincent Lavoue, Camille Mimoun, Cyrille Huchon, Martin Koskas, Helene Costaz, Francois Margueritte, Yohann Dabi, Cyril Touboul, Sofiane Bendifallah, Lobna Ouldamer, Nicolas Delanoy, Huyen-Thu Nguyen-Xuan, Anne-Sophie Bats, Henri Azais
Summary: This retrospective multicenter study assessed the prognostic impact of the FIGO staging classification and the initial metastatic location on survival in patients with ovarian cancer. The study found that patients with FIGO stage IVA had a worse prognosis than those with stage IVB, and initial pleural involvement was a poor prognostic factor. The researchers suggested modifying the current FIGO staging classification.
Article
Oncology
Jin Qian, Jing Wang, Feng Cheng, Hong-feng Guo, Jun Xia, Xin Zhou
Summary: The prognostic value of the controlling nutritional status score (CONUT) in patients with myelodysplastic syndrome (MDS) was evaluated. The results showed that high CONUT score was significantly associated with low hemoglobin levels and indicated poor overall survival. Thrombocytopenia, high CONUT score, and medium and high risk IPSS-R score were identified as independent prognostic factors in MDS patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Environmental Sciences
Foteini Doukalianou, Gavriil Spyroglou, Michail Orfanoudakis, Kalliopi Radoglou, Stefanos Stefanou, Kyriaki Kitikidou, Elias Milios, Alessandra Lagomarsino
Summary: Litterfall and forest floor contribute significantly to the sustainability of forest ecosystems and the exchange of greenhouse gases between soil and the atmosphere. Thinning treatments have a significant impact on litterfall, forest floor nutrients, and soil greenhouse gas fluxes. Selective thinning reduces litterfall production and conifer fractions, while increasing iron and zinc concentrations in the forest floor.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Endocrinology & Metabolism
Christopher T. Su, Emily Nizialek, Jacob E. Berchuck, Panagiotis J. Vlachostergios, Ryan Ashkar, Alexandra Sokolova, Pedro C. Barata, Rahul R. Aggarwal, Rana R. McKay, Neeraj Agarwal, Heather M. McClure, Nellie Nafissi, Alan H. Bryce, Oliver Sartor, Nicolas Sayegh, Heather H. Cheng, Nabil Adra, Cora N. Sternberg, Mary-Ellen Taplin, Marcin Cieslik, Ajjai S. Alva, Emmanuel S. Antonarakis
Summary: PARP inhibitors (PARPi) are standard treatment for mCRPC patients with specific mutations, but response may differ in patients with ATM and BRCA2 mutations. We investigated differences in response to taxanes, which may inform treatment sequencing decisions.
Review
Medicine, General & Internal
Asimina Valsamaki, Maria Xanthoudaki, Katerina G. Oikonomou, Panagiotis J. Vlachostergios, Antonios Papadogoulas, Periklis Katsiafylloudis, Ioanna Voulgaridi, Apostolia-Lemonia Skoura, Apostolos Komnos, Panagiotis Papamichalis
Summary: COVID-19, caused by SARS-CoV-2, emerged in Wuhan, China in December 2019 and quickly spread worldwide, leading to the declaration of a global pandemic by the World Health Organization in March 2020. In addition to respiratory symptoms, the virus also significantly affects various organs, with an estimated 14.8%-53.0% of severe cases experiencing liver injury. Elevated levels of liver enzymes and bilirubin, as well as decreased levels of albumin and prealbumin, are the main laboratory findings. Patients with underlying liver disease are particularly prone to severe liver injury. This literature review provides insights into the pathophysiological mechanisms, drug interactions, early diagnostic tests, and the impact of COVID-19 on healthcare systems and liver transplant programs.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Oncology
Konstantinos Dimitropoulos, Louis L. Pisters, Christos N. Papandreou, Danai Daliani, Anastasios Karatzas, Argiro Petsiti, Vassilios Tassoudis, Eleni Arnaoutoglou, Panagiotis J. Vlachostergios, Vassilios Tzortzis
Summary: This study aimed to investigate whether the implementation of Enhanced Recovery After Surgery (ERAS) protocol in post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) patients could help reduce postoperative pain and opioid use. The results showed that implementing the ERAS protocol improved pain management, optimized patient recovery, and prevented over-prescription of opioid analgesics.
CURRENT CANCER DRUG TARGETS
(2023)
Review
Oncology
Konstantinos Evmorfopoulos, Panagiotis J. Vlachostergios, Petros Sountoulides, Vassilios Tzortzis
Summary: This review discusses the advances in understanding the biology of testicular germ cell tumors (TGCT) and the discovery of biomarkers for diagnosis and treatment evaluation. Serum biomarkers play a significant role in TGCT diagnosis and treatment response evaluation, while molecular biomarkers potentially have important implications for future disease diagnosis, treatment selection, and prognosis assessment.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Christos Tsatsanis, Angel Elenkov, Irene Leijonhufvud, Katerina Vaporidi, Asa Tivesten, Aleksander Giwercman
Summary: Sex hormones and sex chromosomes have different impacts on cytokines involved in sex-dependent inflammatory response. The concentration of BAFF and LPS-stimulated TNF secretion depends on sex hormone levels, while basal TNF is regulated by both sex hormone-dependent and -independent factors.
ENDOCRINE CONNECTIONS
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Evmorfopoulos, Lampros Mitrakas, Athanasios Karathanasis, Ioannis Zachos, Vassilios Tzortzis, Panagiotis J. Vlachostergios
Summary: Upper tract urothelial carcinoma (UTUC) is a rare malignancy involving the renal pelvis, calyces, or ureters. Therapeutic management is challenging and platinum-based chemotherapy has been the standard treatment. Recent advances in the genetic and immune aspects of UTUC have led to the development of precision-based therapeutic approaches, such as immune checkpoint inhibitors and FGFR-targeting agents, improving prognosis for patients.
Article
Forestry
Petros Petrou, Athanasios Stampoulidis, Kyriaki Kitikidou, Elias Milios
Summary: The goal of this study is to compare the diversity of the stand structure of open P. brutia forests in areas of different productivity at middle elevations in central Cyprus. Two plots were established, one in a medium productivity site and one in a bad productivity site. Dendrometrical data and hemispherical photographs were recorded. The results showed that the stand structure is more heterogeneous and complex in medium productivity sites, and P. brutia formations in these sites can support greater biodiversity.
Article
Agronomy
Elias Pipinis, Athanasios Stampoulidis, Aikaterini Angeliki Kotoula, Elias Milios, Stefanos Kostas, Stefanos Hatzilazarou, Evgenia Papaioannou, Alexandros Papaeirinaios, Kyriaki Kitikidou, Kalliopi Radoglou
Summary: Arbutus andrachne, a valuable phytogenetic resource, is an evergreen shrub or small tree native to the Mediterranean basin. This study provided a detailed germination protocol, molecular analysis, and cultivation practices for four Greek natural populations of A. andrachne. Cold stratification or gibberellic acid treatment resulted in similar germination patterns for all populations. Morphological traits showed differences among populations, and plastic bag cultivation showed superior growth rates. Fertilizer supplementation enhanced foliage mass for 2-year-old seedlings. Genetic variability was found within populations rather than among them.
Article
Oncology
Konstantinos Evmorfopoulos, Georgios Chasiotis, Alexandros Barbatis, Ioannis Zachos, George Kouvelos, Metaxia Bareka, Panagiotis J. Vlachostergios, Eleni Arnaoutoglou, Vassilios Tzortzis, Miltiadis Matsagkas
Summary: Testicular germ cell tumors (TGCTs) are a major cause of cancer-related death in males aged 20 to 40. Combination therapy involving cisplatin-based chemotherapy and surgical excision can effectively treat advanced stages of the disease. In some cases, vascular procedures may be necessary during retroperitoneal lymph node dissection (RPLND) to ensure complete removal of residual masses. This study highlights a successful case of post-chemotherapy RPLND with additional replacement of the infrarenal inferior vena cava (IVC) and abdominal aorta using synthetic grafts.
Article
Biochemistry & Molecular Biology
Maria Samara, Panagiotis J. Vlachostergios, Eleni Thodou, Ioannis Zachos, Lampros Mitrakas, Konstantinos Evmorfopoulos, Vassilios Tzortzis, Antonis Giakountis
Summary: This study designed a computational approach to identify a miRNA signature as a non-invasive method for early diagnosis and prognosis of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Panagiotis J. Vlachostergios, Ioannis A. Tamposis, Maria Anagnostou, Maria Papathanassiou, Lampros Mitrakas, Ioannis Zachos, Eleni Thodou, Maria Samara, Vassilios Tzortzis
Summary: This study investigated the clinical and molecular characteristics of HIF-2-altered urothelial carcinoma (UC). The results showed that UC with HIF-2 alterations is associated with higher tumor stage, grade, and lymph node metastasis, as well as shorter progression-free and overall survival. These tumors also exhibit a distinct genomic and immunogenomic profile enriched in genes promoting angiogenesis and immune evasion.
Article
Oncology
Neil J. Shah, Vaibhav G. Patel, Xiaobo Zhong, Luis Pina, Jessica E. Hawley, Emily Lin, Benjamin A. Gartrell, Victor Adorno Febles, David R. Wise, Qian Qin, George Mellgard, Himanshu Joshi, Jones T. Nauseef, David A. Green, Panagiotis J. Vlachostergios, Daniel H. Kwon, Franklin Huang, Bobby Liaw, Scott Tagawa, Philip Kantoff, Michael J. Morris, William K. Oh
Summary: In patients with prostate cancer, androgen deprivation therapy (ADT) does not affect severe COVID-19 outcomes. Age 70 years and older is significantly associated with a higher risk of developing severe COVID-19 disease.
JNCI CANCER SPECTRUM
(2022)
Article
Environmental Studies
Dimitrios Manolopoulos, Konstantinos Vasileioris, Elias Milios, Kyriaki Kitikidou, Gavriil Spyroglou, Kalliopi Radoglou
Summary: This study aimed to develop height growth models for black locust plantations in restoration plantations of former mining areas. The results showed that black locust plantations grow well and are an excellent species for restoring former mines. However, site quality and other factors were not taken into account in this study.
