Article
Oncology
Rieko Kanehara, Ryoko Katagiri, Atsushi Goto, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: This study examined the association between sugar intake and colorectal cancer risk in a Japanese population and found no clear association overall. However, among women, higher sugar intake may increase the risk of rectal cancer.
Article
Oncology
Kristina Vingrys, Michael L. Mathai, Andrew J. McAinch, Julie K. Bassett, Maximilian de Courten, Lily Stojanovska, Lynne Millar, Graham G. Giles, Allison M. Hodge, Vasso Apostolopoulos
Summary: The study investigated the association between cereal polyphenol intake and colorectal cancer risk, but found little evidence of a connection. Future research may be needed to understand the relationships between cereal-derived polyphenols and other cancers in diverse populations.
Article
Oncology
Linyun Fan, Yimin Cai, Haoxue Wang, Heng Zhang, Can Chen, Ming Zhang, Zequn Lu, Yanmin Li, Fuwei Zhang, Caibo Ning, Wenzhuo Wang, Yizhuo Liu, Hanting Li, Gaoyuan Li, Jingyi Peng, Kexin Hu, Bin Li, Chaoqun Huang, Xiaojun Yang, Yongchang Wei, Ying Zhu, Meng Jin, Xiaoping Miao, Jianbo Tian
Summary: Previous investigations mainly focused on the associations of dietary fatty acids with colorectal cancer risk, and this study explored the interactions between genetic risks, dietary fatty acids, and colorectal cancer. Results showed that high intake of saturated fatty acid (SFA) was associated with a higher risk of colorectal cancer, particularly among individuals with high genetic risk. The study also found that a multiplicative interaction between genetic risk and SFA intake increased the risk of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Elom K. Aglago, Amanda J. Cross, Elio Riboli, Veronika Fedirko, David J. Hughes, Agnes Fournier, Paula Jakszyn, Heinz Freisling, Marc J. Gunter, Christina C. Dahm, Kim Overvad, Anne Tjonneland, Cecilie Kyro, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Verena Katzke, Bernard Srour, Matthias B. Schulze, Clemens Wittenbecher, Domenico Palli, Sabina Sieri, Fabrizio Pasanisi, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Torill Enget Jensen, Marko Lukic, Maria-Jose Sanchez, Pilar Amiano, Sandra Colorado-Yohar, Aurelio Barricarte, Ulrika Ericson, Bethany van Guelpen, Keren Papier, Anika Knuppel, Corinne Casagrande, Inge Huybrechts, Alicia K. Heath, Konstantinos K. Tsilidis, Mazda Jenab
Summary: This study examined the association between dietary iron intake and colorectal cancer (CRC) risk. The results showed that in men, higher intake of non-heme iron was associated with a lower risk of CRC, while there was no significant association with total or heme iron intake. In women, there was no significant association between iron intake and CRC risk. Substituting heme iron with non-heme iron was associated with a lower risk of CRC in men.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Ulrik Deding, Gunnar Baatrup, Lasse Kaalby, Morten Kobaek-Larsen
Summary: A prospective study in Denmark found an association between regular consumption of raw carrots and reduced incidence of lung cancer, pancreatic cancer, and leukemia. The preventive effect may be attributed to the polyacetylenic compounds in carrots, while carotene may not have an effect.
Article
Oncology
Harindra Jayasekara, Allison M. Hodge, Andrew Haydon, Robin Room, John L. Hopper, Dallas R. English, Stephanie A. Smith-Warner, Graham G. Giles, Roger L. Milne, Robert J. MacInnis
Summary: The study revealed that long-term alcohol intake, especially heavy drinking, may increase the risk of metachronous cancer, particularly of the colorectum, upper aero-digestive tract, and kidney.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Mathematical & Computational Biology
Colinda C. J. M. Simons, Leo J. Schouten, Roger W. L. Godschalk, Frederik-Jan Van Schooten, Monika Stoll, Kristel Van Steen, Piet A. van den Brandt, Matty P. Weijenberg
Summary: This study investigates the relationship between polygenic risk scores, energy balance-related factors, and colorectal cancer risk. The results suggest that the mTOR-PI3K-Akt pathway may play a role in the development of colon cancer.
Article
Gastroenterology & Hepatology
Ellis L. Eikenbooth, Sarah Moen, Monique E. van Leerdam, Grigorios Papageorgiou, Michail Doukas, Pieter J. Tanis, Evelien Dekker, Anja Wagner, Manon C. W. Spaander
Summary: The risk of metachronous colorectal cancer after partial colectomy in carriers of low-risk variants is similar to the risk after extensive colectomy in carriers of high-risk variants. Partial colectomy followed by endoscopic surveillance is suggested as an appropriate management approach for colorectal cancer in carriers of low-risk Lynch syndrome variants.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Colinda C. J. M. Simons, Nadine S. M. Offermans, Monika Stoll, Piet A. van den Brandt, Matty P. Weijenberg
Summary: Through the Netherlands Cohort Study, researchers identified a chromosomal cluster on chromosome 10 that is associated with both height, postmenopausal breast cancer, and colorectal cancer risks in women, indicating a potential influence of hormone-related growth mechanisms on these phenotypes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Federica Turati, Federica Concina, Marta Rossi, Federica Fiori, Maria Parpinel, Martina Taborelli, Attilio Giacosa, Anna Crispo, Eleonora Pagan, Valentina Rosato, Eva Negri, Carlo La Vecchia
Summary: This study found an inverse association between the intake of galactooligosaccharides (GOSs) and colorectal cancer risk. No association was found with total inulin-type fructans (ITFs) and fructooligosaccharides (FOSs).
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Oncology
Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: Alcohol consumption and cigarette smoking are associated with increased risk of Cancer of Unknown Primary (CUP). Higher levels of alcohol intake and current smoking are linked to higher CUP risk, with a dose-response relationship observed for both factors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Landon T. Fike, Heather Munro, Danxia Yu, Qi Dai, Martha J. Shrubsole
Summary: This study demonstrated that increasing intakes of total polyphenols, tyrosols, and hydroxybenzoic acids were associated with decreased risk of colorectal cancer or rectal cancer, and these associations were consistent across subgroups based on sex, race, income, and BMI. Differences in polyphenol intakes may contribute to the increased incidence of colorectal cancer among Black individuals in the United States.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Oncology
Guoqiao Zheng, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: Individuals with a family history of both CRCa-1 and CRCa-2 have a lower risk of CRC compared to individuals with only CRCa-1, which is related to the age of diagnosis of CRC in FDR and family relationships.
Article
Oncology
Mark A. Jenkins
Summary: The study identified significant familial risk factors affecting colorectal cancer risk for Lynch syndrome carriers, resulting in a wide variation in risk between carriers of the same gene. This highlights the importance of personalized risk assessments for precision prevention and early detection of colorectal cancer in individuals with Lynch syndrome.
Article
Nutrition & Dietetics
Xuechen Chen, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to assess the impact of high red and processed meat intake (RPMI) on colorectal cancer (CRC) risk and compare it with genetically determined risk. The study found that RPMI increases CRC risk regardless of genetic risk. Avoiding RPMI can compensate for a substantial proportion of polygenic risk for CRC.
Article
Nutrition & Dietetics
Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study examined the association between adherence to the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) recommendations and risk of Cancer of Unknown Primary (CUP). The findings suggest that highest adherence to the recommendations is not statistically significantly associated with decreased CUP risk after multivariable adjustment.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Iris W. A. Boot, Anke Wesselius, Evan Y. W. Yu, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Pietro Ferrari, Matthias B. Schulze, Bas Bueno-de-Mesquita, Maria Jose-Sanchez, Bjorn Gylling, Maurice P. Zeegers
Summary: This study found that B group vitamins may play a role in preventing bladder cancer, and different genders have different associations between the intake of various vitamins and bladder cancer risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pathology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study found that CRC patients with Warburg-high subtype had the poorest survival rates, especially for those with TNM stage III CRC and cancers located in the rectum. Further research is needed to confirm the findings and explore the potential clinical utility of Warburg subtypes in CRC.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Oncology
Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study investigated the association between vegetable and fruit intake and the risk of Cancer of Unknown Primary (CUP). The results showed that overall, vegetable and fruit consumption was not associated with CUP incidence.
Article
Oncology
Karlijn E. P. E. Hermans, Sharmi Haque, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten
Summary: This study examines the association between type 2 diabetes mellitus (T2DM) and cancer of unknown primary (CUP) in depth, and finds a nonsignificant positive association between T2DM and CUP risk. The association becomes stronger in women.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Alicia K. Heath, David C. Muller, Piet A. van den Brandt, Elena Critselis, Marc Gunter, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Pietro Ferrari, Melissa A. Merritt, Agnetha L. Rostgaard-Hansen, Anne Tjonneland, Kim Overvad, Verena Katzke, Bernard Srour, Giovanna Masala, Carlotta Sacerdote, Fulvio Ricceri, Fabrizio Pasanisi, Bas Bueno-de-Mesquita, George S. Downward, Guri Skeie, Torkjel M. Sandanger, Marta Crous-Bou, Miguel Rodriguez-Barranco, Pilar Amiano, Jose Maria Huerta, Eva Ardanaz, Isabel Drake, Mikael Johansson, Ingegerd Johansson, Tim Key, Nikos Papadimitriou, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Summary: The association between diet and lung cancer risk, particularly with specific foods or nutrients, remains unclear. This study found that higher intake of fiber, fruit, and vitamin C were associated with a lower risk of lung cancer, while higher intake of offal, retinol, and beer/cider were positively associated with lung cancer risk. The associations were not different between sexes and were less significant among never smokers. The associations found in this study were not replicated in a separate cohort study, except for the inverse associations of fruit and vitamin C with squamous cell carcinoma.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Chiara Stival, Alessandra Lugo, Anna Odone, Piet A. van den Brandt, Esteve Fernandez, Olena Tigova, Joan B. Soriano, Maria Jose Lopez, Silvia Scaglioni, Silvano Gallus
Summary: Based on the data from the TackSHS survey, this study provides updated estimates of the prevalence and determinants of overweight and obesity in Europe. The results show that overweight and obesity are highly prevalent in Europe, particularly in Eastern and Northern European countries. Moreover, there has been an increasing trend in obesity prevalence in these regions compared to 2010.
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the prognostic value of mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, MET, and mismatch repair (MMR) status in colorectal cancer (CRC) patients. The results showed that mutational subgroups were associated with survival differences in CRC patients, while Warburg-subtypes did not provide additional prognostic information within these mutational subgroups.
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van den Brandt
Summary: In this study, the authors found that metabolic Warburg-subtypes can predict the survival benefit from adjuvant therapy in colorectal cancer patients. Patients with moderate metabolic Warburg-subtype had a survival benefit from adjuvant therapy, while patients with low metabolic Warburg-subtype did not.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Romain Meer, Jeroen van de Pol, Piet A. van den Brandt, Leo J. J. Schouten
Summary: This study examined the association between a Healthy Lifestyle Index score and renal cell cancer risk using data from the Netherlands Cohort Study. The study found a weak, non-statistically significant association between adherence to a healthy lifestyle and a lower risk of renal cell cancer.
Article
Public, Environmental & Occupational Health
Silvano Gallus, Alessandra Lugo, Chiara Stival, Sonia Cerrai, Luke Clancy, Filippos T. Filippidis, Giuseppe Gorini, Maria Jose Lopez, Angel Lopez-Nicolas, Sabrina Molinaro, Anna Odone, Joan B. Soriano, Olena Tigova, Piet A. van den Brandt, Constantine I. Vardavas, Esteve Fernandez
Summary: According to the survey conducted by the TackSHS project, over 8.3 million adults in 12 European countries use electronic cigarettes. The majority of users are dual users, using both electronic and conventional cigarettes, using electronic cigarettes with nicotine, and using them in smoke-free indoor areas.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pathology
Bartholomeus G. H. Latten, Bela Kubat, Piet A. van den Brandt, Axel zur Hausen, Leo J. Schouten
Summary: The autopsy rate is declining while major discrepancies exist between autopsies and clinical diagnoses. This study aims to investigate the relationship between the cause of death, a history of cancer, and the autopsy rate. The findings of this study are important in understanding the impact of cancer on autopsies and can help counteract the decline in the medical autopsy.
Article
Oncology
Selena Odeh, Iryna V. Samarska, Andres Matoso, Jeroen A. A. Van De Pol, Marcella M. L. L. Baldewijns, Christina A. A. Hulsbergen-Van De Kaa, Jaleesa Van Der Meer, Guido Roemen, Erik Geelkens, Manon Van Engeland, Axel Zur Hausen, Leo J. Schouten, Kim M. Smits
Summary: The aim of this study was to re-evaluate renal cell carcinoma cases from a large population-based cohort in the Netherlands, using new classifications, in order to identify newly recognized subtypes. The cases were initially evaluated using previous classifications and data on clinicopathological characteristics were obtained. Two urogenital pathologists reviewed digital slides according to new grading and classification systems. No new RCC subtypes were identified in the cases. Restaging and regrading showed the possibility of reporting newer features in an old sample collection.
