Article
Nutrition & Dietetics
Mahasin Abdel Rhman, Nikita Devnarain, Rene Khan, Peter M. O. Owira
Summary: This study reveals that the combination of quercetin and naringenin in citrus fruits and vegetables can synergistically induce oxidative stress and apoptosis, and reduce cell proliferation in breast cancer cells.
Article
Environmental Sciences
Seonggyu Bang, Ahmad Yar Qamar, Bereket Molla Tanga, Xun Fang, Gyeonghwan Seong, Abdelbagi Hamad Talha Nabeel, Il-Jeoung Yu, Islam M. Saadeldin, Jongki Cho
Summary: The study found that the addition of 50 μM QRN can reduce oxidative damage to ejaculated sperm in dogs and improve their quality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Amarjot Kaur Grewal, Thakur Gurjeet Singh, Deepak Sharma, Veerta Sharma, Manjinder Singh, Md. Habibur Rahman, Agnieszka Najda, Magdalena Walasek-Janusz, Mohamed Kamel, Ghadeer M. Albadrani, Muhammad Furqan Akhtar, Ammara Saleem, Mohamed M. Abdel-Daim
Summary: Quercetin, a flavonoid widely distributed among plants, has significant pharmacological effects and therapeutic potential, showing neuroprotection by modulating and inhibiting a wide range of pathways. Its exact mechanisms of action remain a mystery, but studies have explored its role in enhancing neuronal longevity and neurogenesis in the context of neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Michael A. Fawzy, Gehad Nasr, Fares E. M. Ali, Moustafa Fathy
Summary: This study aimed to investigate the regulatory effects of quercetin (QU) on selected phosphodiesterase inhibitors against alpha-naphthyl isothiocyanate (ANIT)-induced acute intrahepatic cholestasis. The combination treatment of QU with sildenafil (Sild) or pentoxifylline (PTX) showed promising hepatoprotective effects and anti-cholestatic properties in improving ANIT-induced liver injury.
Article
Environmental Sciences
Diogo Ferreira Bicca, Cristiano Chiapinotto Spiazzi, Juliana Bernera Ramalho, Melina Bucco Soares, Francielli Weber Santos Cibin
Summary: The study revealed that subchronic low dose of GBH could affect behavior and oxidative stress in mouse hippocampus. Quercetin treatment partly or fully improved these effects, but caution is needed regarding the potential independent effects of continuous quercetin supplementation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Plant Sciences
Arash Karimi, Fatemeh Naeini, Vahid Asghari Azar, Malihe Hasanzadeh, Alireza Ostadrahimi, Hamid Reza Niazkar, Majid Mobasseri, Helda Tutunchi
Summary: Quercetin supplementation shows potential therapeutic effects on sepsis by attenuating inflammation and oxidative stress, downregulating toll-like receptors (TLRs), modulating immune response, and alleviating organ dysfunction. Future human randomized clinical trials are needed to further explore its clinical benefits.
Article
Horticulture
Muhammad Waqas, Li Wang, Jeffrey J. Jones, Reinhard Josef Turetschek, Doris Engelmeier, Christoph-Martin Geilfus, Mirjam Koch
Summary: Plants suffering from phosphorus deficiency produce flavonoids to adapt to the conditions, which provide antioxidative properties and protect the chloroplasts from excessive light energy. A study aimed to induce the accumulation of flavonoids in pak choi before harvest by subjecting it to a short P deficiency. The experiment resulted in increased flavonoid content in the harvested leaf but also caused water loss in the entire shoot, leading to reduced marketable yield.
SCIENTIA HORTICULTURAE
(2023)
Article
Environmental Sciences
Xia Wu, Li-Jun Wang, Yu Hou, Rui-Ying Guo, Min Liu, Li Yang, Ji-Liang Zhang
Summary: The study suggests that low-level quercetin may be beneficial for the nervous system, while high-level quercetin could be harmful. Different levels of quercetin have different mechanisms of action, which require further attention. High-level quercetin may increase the risk of neurodegenerative diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Integrative & Complementary Medicine
Damilare E. Rotimi, Tomilola D. Olaolu, Oluyomi S. Adeyemi
Summary: The testis is susceptible to oxidative stress and inflammation, which are major factors in male infertility. Quercetin, with its antioxidant and anti-inflammatory properties, has been shown to improve male reproductive function by ameliorating altered sperm function, reproductive hormone dysfunction, dysregulated testicular apoptosis, oxidative stress, and inflammation.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Health Care Sciences & Services
Francesca Carriero, Carolina Martinelli, Fabio Gabriele, Giulia Barbieri, Lisa Zanoletti, Gloria Milanesi, Claudio Casali, Alberto Azzalin, Federico Manai, Mayra Paolillo, Sergio Comincini
Summary: The combination of the plant alkaloid berberine with photodynamic therapy has shown a potential anticancer strategy for high malignant gliomas by inducing apoptosis pathway through massive ROS production, mitochondria depolarization, and activation of caspases.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jianhao Peng, Siyuan Wang, Yunlong Wang, Wanchao Yu, Yejun Zha, Shuxin Gao
Summary: Ozone pollution is a significant environmental concern and exposure to ozone increases the risk of metabolic liver disease. However, there is limited research on the mechanisms underlying the effects of ozone exposure on liver oxidative damage and lipid metabolism. In this study, human hepatocellular carcinoma cells were exposed to 200 ppb ozone for various durations. The results showed elevated levels of oxidative stress and disrupted lipid metabolism in the cells, leading to intracellular lipid accumulation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Eva Tvrda, Jan Kovac, Kristina Ferenczyova, Barbora Kalocayova, Michal Duracka, Filip Benko, Viera Almasiova, Monika Bartekova
Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ashraf Albrakati
Summary: This study showed that apigenin, a flavonoid, has neuroprotective effects against neural damage caused by MSG in rats. Apigenin increased the activity of acetylcholinesterase and levels of brain monoamines, while decreasing the activity of monoamine oxidase. It also reduced oxidative stress and inflammation, and restored the cytoarchitecture of the brain cortex.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Sanchaita Mondal, Sujata Das, Pradip Kumar Mahapatra, Krishna Das Saha
Summary: In this study, we investigated the effectiveness of morin encapsulated chitosan nanoparticles (MCNPs) against arsenic induced liver damage in mice. The results showed that MCNPs significantly reduced the liver function indicators, improved hematological and serum biochemical parameters, and decreased arsenic deposition in mice treated with arsenic. In addition, MCNPs demonstrated antioxidant, antiapoptotic, and anti-inflammatory effects.
NANOSCALE ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Ewa Mlyczynska, Malgorzata Myszka, Patrycja Kurowska, Monika Dawid, Tomasz Milewicz, Marta Balajewicz-Nowak, Pawel Kowalczyk, Agnieszka Rak
Summary: The study demonstrated the antiapoptotic effect of apelin on trophoblast cells by regulating the expression of pro-survival and proapoptotic factors, as well as attenuating oxidative stress. This effect was mediated by the APJ receptor and specific signaling pathways like mitogen-activated protein kinase (ERK1/2/MAP3/1) and protein kinase B (AKT), suggesting the potential role of apelin in placental development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
