Article
Chemistry, Multidisciplinary
Fatemeh Mohajer, Ghodsi Mohammadi Ziarani, Alireza Badiei, Leonid G. Voskressensky, Rafael Luque
Summary: Novel sulfonated mesoporous hybrid organic-inorganic catalyst SBA@Pr-3AP-SO3H, anchored to the pore walls of SBA-15, was synthesized through a series of reactions. It exhibited efficient performance in the synthesis of phenyl-[1,2,4]-triazolidines.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Priyanka Kalal, Nusrat Sahiba, Ayushi Sethiya, Pankaj Teli, Deepkumar Joshi, Shikha Agarwal
Summary: A facile approach for the synthesis of bioactive acridinedione analogs using dimedone, aryl aldehydes, and ammonium acetate was developed. The method is efficient, simple, environmentally friendly, and has a short reaction time with high yields. The synthesized derivatives exhibit significant activity against various bacterial and fungal strains.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Inorganic & Nuclear
Ghodsi Mohammadi Ziarani, Shima Roshankar, Fatemeh Mohajer, Alireza Badiei, Mika Sillanpaa
Summary: A fluorescent chemosensor based on isatin was synthesized by modifying and functionalizing mesoporous material SBA-15. The sensor showed high selectivity and low detection limit for Hg2+ ion in aqueous media.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhong Yan, Ying Zhou, Yuwei Liu, Chao Xue, Chenguang Yang, Junjie Wang, Wenwen Wang, Dong Wang
Summary: Using a facile photoinduced grafting strategy, a fabric nylon-supported poly (styrene sulfonic acid) brush catalyst was successfully developed, which can act as an efficient and recyclable Bronsted acid catalyst. The catalyst showed high catalytic activity for the condensation reaction of anthranilamide with aldehydes or ketones in ethanol, with yields ranging from 90% to 97% in 15 examples. It also demonstrated superior stability and catalytic activity even after 15 runs, making it easily recyclable and reusable.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Chemistry, Organic
Tran Quang Hung, Ban Van Phuc, Pham Thi Thanh Loan, Do Thi Lan Nhi, Hien Nguyen, Hoan Xuan Vu, Dang Van Do, Tuan Thanh Dang
Summary: The aim of this study was to explore new applications of non-metal heterogeneous catalysts in the synthesis of 1,4-DHP derivatives. A greener and more efficient method for the synthesis of 1,4-DHPs and asymmetric 1,4-DHP (Felodipine drug) was successfully developed using a heterogeneous SBA-15-SO3H catalyst. The catalyst exhibited efficient activity, stability, and could be recycled at least 5 times without losing catalytic activity.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Chemistry, Physical
Roya Mozafari, Zahra Gheisvandi, Mohammad Ghadermazi
Summary: In this research project, an environmentally friendly solid catalyst was synthesized from low-cost rice husk and applied to support cobalt ferrite. The modified nanoparticles were characterized, and the effect of the catalyst preparation method was extensively studied against the synthesis of specific compounds. The nontoxic nature, short reaction times, easy recovery, and efficient reusability of the catalyst are advantages of this approach.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Javad Safaei-Ghomi, Zahra Elyasi, Pouria Babaei
Summary: This study focused on the synthesis and catalytic performance of N-doped graphene quantum dots modified with CuO/ZnO nanoarrays in a one-pot synthesis of monospiro-2-amino-4H-pyrans. The CuO/ZnO@N-GQDs nanocomposite exhibited the highest catalytic activity compared to pure N-GQDs and CuO/ZnO, facilitating the formation of new sigma bonds in a multicomponent reaction. Additionally, the recoverability of the CuO/ZnO@N-GQDs heterogeneous nanocatalyst was demonstrated after multiple cycles with minimal loss of activity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Priyanka Yadav, Praachi Kakati, Preeti Singh, Satish K. Awasthi
Summary: The work involved the design and synthesis of an efficient sulfonated cobalt ferrite solid acid catalyst, which was used for the synthesis of biologically significant compounds with high yield, short reaction time, and excellent green chemistry metrics.
APPLIED CATALYSIS A-GENERAL
(2021)
Article
Chemistry, Multidisciplinary
Fatima Hajizadeh, Mohammad M. Mojtahedi, M. Saeed Abaee
Summary: An efficient metal-free four-component approach for synthesizing piperazine derivatives tethered to an isothiourea group via an ethylene link was developed. The method utilizes in situ generated DABCO salts and involves a two parallel nucleophilic paths to achieve the target products. The protocol exhibited good tolerance towards various DABCO salts and secondary amines, yielding the desired isothiourea-ethylene-tethered-piperazine compounds in high yields.
Article
Chemistry, Physical
Archana Yadav, Pradeep Patil, Dattatray Chandam, Sushilkumar Jadhav, Anil Ghule, Shankar Hangirgekar, Sandeep Sankpal
Summary: The study presents a novel method for synthesizing a magnetic separable nanocomposite catalyst, which efficiently catalyzes the synthesis of diheteroarylmethanes under environmentally friendly conditions. It offers advantages of multiple recyclability, mild reaction conditions, high yields, and ease of catalyst separation.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Tao Liu, Xiaoqiu Ju, Zhixin Hu, Rongrong Xie
Summary: The confinement effect of ordered mesoporous SiO2 was found to effectively inhibit the aggregation of CoOx, promoting the formation of Co(III) species and enhancing the catalytic activity for CO oxidation. Additionally, the pore size of the carrier SBA-15 played a significant role in the catalytic activity of CoOx.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Mina Keihanfar, Bi Bi Fatemeh Mirjalili
Summary: In this study, a novel catalyst based on natural material was designed and prepared. The properties of the catalyst were characterized using various analytical techniques, and its catalytic activity was evaluated in the synthesis of naphtho-1,3-oxazines. The protocol offers advantages such as solvent-free conditions, simplicity of operation, and the use of an eco-friendly catalyst.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Organic
Madhav J. Hebade, Tejshri R. Deshmukh, Sambhaji T. Dhumal
Summary: A simple method for synthesizing quinoxalines using DTP/SiO2 as a recyclable catalyst is proposed in this study, which offers advantages such as environmentally friendly, high yield, low cost, and recyclability, leading to improved affordability and efficiency.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Maryam Mehravar, Bi Bi Fatemeh Mirjalili, Elaheh Babaei, Abdolhamid Bamoniri
Summary: The nano-SiO2/1,5-diazabicyclo[4.3.0]non-5-en was synthesized and used as a heterogeneous nanocatalyst for the synthesis of tetrahydrobenzo[b]pyran derivatives. The results showed that tetrahydrobenzo[b]pyrans were synthesized in good to high yields and short reaction times, highlighting the efficiency and effectiveness of this method. Overall, the method offers advantages such as short reaction time, simplicity, catalyst recyclability, and high product yields.
Article
Nanoscience & Nanotechnology
Graziano Di Carmine, Costanza Leonardi, Luke Forster, Min Hu, Daniel Lee, Christopher M. A. Parlett, Olga Bortolini, Mark A. Isaacs, Alessandro Massi, Carmine D'Agostino
Summary: The alcoholysis of furfuryl alcohol in SBA-15-pr-SO3H catalysts with different pore sizes was studied. Results showed that changes in pore size have a significant effect on catalyst activity and durability, with larger-pore-size catalysts deactivating more rapidly. The presence of SO3H groups on the external surface and reduced pore clogging were identified as factors contributing to the increased reusability of smaller-pore-size catalysts.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Medicinal
Drashti G. Daraji, Dhanji P. Rajani, Smita D. Rajani, Edwin A. Pithawala, Sivaraman Jayanthi, Hitesh D. Patel
Summary: In this study, a series of new imidazole derivatives were synthesized and tested for their antibacterial activity. The 12l compound showed high potency against various bacterial strains including ESBL, VRE, and MRSA. Through ADME studies and molecular docking research, it was found that these synthetic compounds have good drug-likeness properties and promising binding modes with the protein.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Chemistry, Organic
Dhaval B. Patel, Jagruti A. Parmar, Siddharth S. Patel, Unnati J. Naik, Hitesh D. Patel
Summary: The synthesis of ester-containing heterocyclic compounds through multicomponent reaction is a preferable process in synthetic organic and medicinal chemistry. The development of new synthetic methods for ester synthesis is necessary, considering the drawbacks of some existing methods. Multicomponent reactions are a powerful tool for one-pot ester synthesis, and recent developments in this area have been reviewed in this article.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
H. P. Vankar, V. A. Rana, S. Dey, H. D. Patel, V. K. Jain
Summary: The study investigated the complex permittivity spectra of binary mixtures of 3-bromoanisole (3-BA) and methanol (MeOH) over a wide microwave frequency range, and analyzed molecular interactions using dielectric relaxation models. The temperature and concentration dependent static permittivity provided information about molecular alignment and cross-linkage in liquid mixtures.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Physical
Prachi T. Acharya, Zeel A. Bhavsar, Divya J. Jethava, Dhaval B. Patel, Hitesh D. Patel
Summary: This study focuses on the synthesis and biological activities of new thiosemicarbazide derivatives in recent years, highlighting highly effective and selective thiosemicarbazide analogues as well as structure-activity relationship studies.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Multidisciplinary
Siddharth S. Patel, Dhaval B. Patel, Hitesh D. Patel
Summary: Nitration of aromatic compounds is a powerful and widely used transformation that allows introducing nitro group into aromatic systems. New synthetic strategies for aromatic nitration are needed for producing important products such as dyes & intermediate compounds, drugs, and Agrochemicals. The main focus is on the most recent developments in methodologies for aromatic nitration from 2017-2020, highlighting their pros and cons and specific reaction mechanisms.
Article
Chemistry, Organic
Drashti G. Daraji, Dhanji P. Rajani, Sivaraman Jayanthi, Hitesh D. Patel
Summary: In recent years, the development of new drugs as antibacterial agents has been a crucial resolution to combat drug-resistant pathogens. Imidazole derivatives were synthesized and characterized for their antimicrobial activity, with some showing potential against clinically relevant strains. Additionally, these compounds were also evaluated for their antituberculosis and antimalarial activities.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Prachi T. Acharya, Zeel A. Bhavsar, Divya J. Jethava, Dhanji P. Rajani, Edwin Pithawala, Hitesh D. Patel
Summary: The antimicrobial, anti-tubercular, antimalarial, and antioxidant properties of a series of benzimidazole hybrid thiosemicarbazide derivatives were investigated in vitro. The majority of the compounds studied showed excellent antibacterial and antioxidant properties. In addition, an in silico investigation was conducted to assess the pharmacokinetic properties of the synthesized compounds, indicating their potential for developing novel active drugs.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Geochemistry & Geophysics
Bimalkumar Patel, R. K. Sarangi, Apurva Prajapati, Bhargav Devliya, Hitesh Patel
Summary: TSM is an essential parameter that impacts the biogeochemistry of the ocean. This study aims to develop a TSM algorithm using remote sensing to monitor TSM concentration in the coastal waters of Gujarat. The developed algorithm showed good performance and was successfully validated with in situ data.
Article
Chemistry, Physical
Siddharth S. Patel, Dhaval B. Patel, Akhil K. Poddar, Jitesh B. Patel, Dharmarajsinh N. Rana, Kirti P. Patel, Shweta P. Thakar, Hitesh D. Patel
Summary: Nitration of aromatic compounds is an important transformation in synthetic organic chemistry. We have developed copper phthalocyanine tetrasulfonic acid as a biodegradable and recyclable solid acid catalyst for aromatic nitration. This catalyst has excellent catalytic activity and can be recycled after completion of the reaction, making the method more efficient, greener, and safer than conventional methods.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Kajalben B. Patel, Dhanji Rajani, Iqrar Ahmad, Harun Patel, Hitesh D. Patel, Premlata Kumari
Summary: Ten chrysin-based pyrimidine-piperazine hybrids were evaluated for their antimicrobial activity against bacterial and fungal strains. The compounds exhibited moderate to good inhibition, with MIC values ranging from 6.25 to 250 ug/ml. Compounds 5b and 5h showed promising potency against E. coli, surpassing commonly used antibiotics. Compound 5g also displayed strong efficacy against a fungal strain.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Inorganic & Nuclear
Manoj N. Bhoi, Mayuri A. Borad, Ankita P. Solanki, Hitesh D. Patel
Summary: A highly efficient and convergent synthesis of fourteen single isomer derivatives of ethyl-2-methyl-4-(pyridin-2-yl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate has been developed via a one-pot, three-component reaction. The synthesis was catalyzed by D-(+)-10-camphorsulphonic acid (D-(+)-10-CSA) and achieved good yields (up to 82%) and excellent enantioselectivities (84-99%ee). The final compounds demonstrated enhanced antibacterial properties compared to the standard drug.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Marine & Freshwater Biology
Bimalkumar Patel, Apurva Prajapati, Ranjit Kumar Sarangi, Bhargav Devliya, Hitesh D. Patel
Summary: The nutrient concentrations in seawater from different locations along the Gujarat coast were analyzed. The results showed higher concentrations of nitrate, silicate, and orthophosphate in southern Gujarat, which could be attributed to nitrification and eutrophication caused by the gulf, estuary zone, heavy sedimentation, and industrial fluxes. Further research on eutrophication in the southern Gujarat coastal region is recommended.
Review
Pharmacology & Pharmacy
Dushyant D. Kotadiya, Piyushkumar Patel, Hitesh D. Patel
Summary: The cellular membrane poses a challenge to drug delivery, but cell-penetrating peptide (CPP) offers a promising solution with its efficient internalization and low toxicity. CPP-cargo complex effectively delivers chemotherapeutic agents and addresses limitations of current therapies. However, no CPP complex is approved by the US FDA. This review discusses CPP as a delivery vehicle, cellular uptake mechanism, design strategies, and recent market status.
CURRENT DRUG DELIVERY
(2023)
Article
Marine & Freshwater Biology
Ranjit Kumar Sarangi, S. N. N. Jaiganesh, Bimalkumar R. Patel, Apurva Prajapati, Hitesh D. Patel
Summary: In this study, in situ sampling and analysis were conducted in the northeast Arabian Sea, specifically in Diu and Daman coastal waters, to assess water quality and bio-optical parameters. The objective was to develop a particulate organic carbon (POC) algorithm using in situ and hyperspectral radiometer data. Correlation analyses and 3-dimensional correlations were performed to determine the relationship between POC and remote sensing reflectance (R-rs) measurements. The results showed the importance of regional POC algorithms based on sufficient in situ data points.
Article
Chemistry, Multidisciplinary
Siddharth S. Patel, Dhaval B. Patel, Akhil K. Poddar, Jitesh B. Patel, Dharmarajsinh N. Rana, Kirti P. Patel, Hitesh D. Patel
Summary: In this article, a new method for the selective reduction and esterification of aromatic carboxylic acids was introduced, utilizing a solid acid catalyst CuPcS and sodium borohydride in THF. This method offers advantages such as shortened reaction times, improved safety conditions, and easy recycling of CuPcS, contributing to increased efficiency and sustainability in the esterification process.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
