Article
Medicine, General & Internal
Malene Martini Clausen, Esben Andreas Carlsen, Camilla Christensen, Jacob Madsen, Malene Brandt-Larsen, Thomas Levin Klausen, Soren Holm, Annika Loft, Anne Kiil Berthelsen, Niels Kroman, Ulrich Knigge, Andreas Kjaer
Summary: Arginine-Glycine-Aspartate (RGD)-recognizing cell surface integrins play important roles in tumor growth and angiogenesis. Positron emission tomography (PET) allows evaluation of integrin α(v)β(3) expression in tumors. In this first-in-human phase I study, researchers assessed the use of [Ga-68]Ga-NODAGA-E[c(RGDyK)](2) PET in patients with neuroendocrine neoplasms and breast cancer, and found it to be safe and effective for imaging integrin α(v)β(3) with low radiation exposure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Esben Andreas Carlsen, Mathias Loft, Annika Loft, Dorota Czyzewska, Mikkel Andreassen, Seppo W. Langer, Ulrich Knigge, Andreas Kjaer
Summary: In this study, 68Ga-NODAGA-E[c(RGDyK)]2 PET/CT was used to image integrin av33 in patients with neuroendocrine neoplasms (NENs). It was found that high uptake was associated with a poorer prognosis. This suggests that 68Ga-NODAGA-E[c(RGDyK)]2 PET/CT may serve as a tool for predicting patients eligible for treatments targeting integrin av33.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Barbara Gyuricza, Judit P. Szabo, Viktoria Arato, Daniel Szucs, Adrienn Vagner, Dezso Szikra, Aniko Fekete
Summary: A novel radiotracer for cancer diagnosis containing lactosamine was successfully synthesized, showing high affinity and stability. The compound was labeled with a Ga-68 isotope with high radiochemical purity. This radiopharmaceutical has potential applications in tumor imaging in the future.
Article
Medicine, General & Internal
Arghavan Jahandideh, Mia Stahle, Jenni Virta, Xiang-Guo Li, Heidi Liljenbaeck, Olli Moisio, Juhani Knuuti, Anne Roivainen, Antti Saraste
Summary: The study demonstrated the potential of using alpha(v)beta(3)-targeting PET imaging with [Ga-68]Ga-NODAGA-RGD to specifically detect myocardial inflammation in a rat model of autoimmune myocarditis. The results showed higher accumulation of the tracer in inflamed myocardium compared to non-inflamed tissue, indicating its efficacy in identifying active inflammatory lesions.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sona Krajcovicova, Andrea Daniskova, Katerina Bendova, Zbynek Novy, Miroslav Soural, Milos Petrik
Summary: The study synthesized DFO-c(RGD) peptide conjugate for radiolabeling with gallium-68 and demonstrated its high stability and tumor-targeting properties. The radiolabeled peptide showed hydrophilic properties, high stability, and specific uptake in tumor cell lines both in vitro and in vivo, making it a promising tool for imaging tumor-induced angiogenesis by positron emission tomography.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Wang, Chao Wang, Minzhou Huang, Songbing Qin, Jun Zhao, Shibiao Sang, Meng Zheng, Yicong Bian, Chenrong Huang, Hua Zhang, Lingchuan Guo, Jiwei Jiang, Chun Xu, Na Dai, Yushuang Zheng, Jiajun Han, Min Yang, Tao Xu, Liyan Miao
Summary: In this study, a novel probe, (68) Ga-NODAGA-SNA006, was developed and evaluated for instant PET imaging of CD8(+) T cells. The results showed specific uptake of (68) Ga-NODAGA-SNA006 in CD8-rich tissues and CD8(+) tumor lesions, indicating its potential for tracking CD8(+) T cells and monitoring immune responses for individualized cancer immunotherapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Medicinal
Theodora Chatzisideri, Panagiotis Dalezis, George Leonidis, Spyridon Bousis, Dimitrios Trafalis, Francesca Bianchini, Vasiliki Sarli
Summary: This study developed c(RGDyK)-CUCU conjugates for selective delivery of CUCUs to integrin-overexpressing cancer cells, showing activity against these cancer cells. The conjugates were approximately three times more active than free CUCU-D in MCF-7 cells.
FUTURE MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jie Zang, Xuejun Wen, Rong Lin, Xinying Zeng, Chao Wang, Mengqi Shi, Xueyuan Zeng, Jiaying Zhang, Xiaoming Wu, Xianzhong Zhang, Weibing Miao, Pengfei Xu, Zhide Guo, Jingjing Zhang, Xiaoyuan Chen
Summary: In this study, the specificity, pharmacokinetics, and dosimetry of the dual targeting PET tracer [Ga-68]Ga-FAPI-RGD were evaluated through preclinical and preliminary clinical studies. The results showed that [Ga-68]Ga-FAPI-RGD had good stability and favorable binding affinity and specificity. It also exhibited significantly improved tumor uptake and retention compared to its monomeric counterparts.
Article
Biochemistry & Molecular Biology
Ibolya Kalman-Szabo, Judit P. Szabo, Viktoria Arato, Noemi Denes, Gabor Opposits, Istvan Joszai, Istvan Kertesz, Zita Kepes, Aniko Fekete, Dezso Szikra, Istvan Hajdu, Gyorgy Trencsenyi
Summary: This study investigated the GRPR specificity of the newly synthesized [Sc-44]Sc-NODAGA-AMBA and its potential as a valuable radiotracer in the imaging of GRPR-positive PCa through in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
George Leonidis, Anastasia Koukiali, Ioanna Sigala, Katerina Tsimaratou, Dimitris Beis, Thomas Giannakouros, Eleni Nikolakaki, Vasiliki Sarli
Summary: This study presents the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates, and investigates their chemostability, cytotoxic and antiangiogenic properties. Most conjugates retained mid nanomolar-level inhibitory activity against SRPK1 kinase, and two conjugates showed antiproliferative effects against multiple cancer cells. In vivo zebrafish screening assays demonstrated the ability of the synthesized conjugates to inhibit intersegmental vessels. Additionally, flow cytometry experiments revealed receptor-mediated endocytosis of the conjugates in specific cancer cells.
Article
Pharmacology & Pharmacy
Kohta Mohri, Kim Phuong Huynh Nhat, Maki Zouda, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Shunsuke Tagami, Hidefumi Mukai
Summary: In this study, we generated a PET probe based on MccJ25 analog with an RGD motif and investigated its utility for tumor imaging. The probe showed high accumulation in tumors with integrin alpha v beta 3 expression and low non-specific accumulation in other tissues. These results suggest that MccJ25 variants can be useful tools for cancer molecular imaging.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pathology
M. Dietz, M. Nicod Lalonde, P. Omoumi, N. Testart Dardel, T. Huegle, J. O. Prior
Summary: In a 65-year-old female with squamous cell carcinoma of the tongue, Ga-68 Ga-NODAGA-RGDyk PET/CT and F-18 FDG PET/CT scans revealed interesting findings regarding the uptake of tracers in the primary tumor, lymph nodes, and joints affected by rheumatoid arthritis. The study suggests that Ga-68 Ga-NODAGA-RGDyk PET/CT may provide a better imaging of integrins expression in rheumatoid arthritis compared to F-18 FDG PET/CT.
MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE
(2021)
Review
Biochemistry & Molecular Biology
Christos Liolios, Christos Sachpekidis, Antonios Kolocouris, Antonia Dimitrakopoulou-Strauss, Penelope Bouziotis
Summary: Multimeric ligands consisting of multiple pharmacophores connected to a single backbone have been widely studied for diagnostic and therapeutic purposes. In targeting integrin alpha(v)beta(3) receptors on cancer cells for molecular imaging and diagnostic applications, multimeric radioligands have shown superiority over monomers. Structural characteristics, binding avidity, pharmacodynamic properties, and PET imaging features of these multimeric ligands have been comprehensively analyzed and discussed in this review.
Article
Medicine, Research & Experimental
Rongxi Wang, Vivianne Jakobsson, Jiarou Wang, Tianzhi Zhao, Xingtong Peng, Bowen Li, Jianchao Xue, Naixin Liang, Zhaohui Zhu, Xiaoyuan Chen, Jingjing Zhang
Summary: This study evaluated the feasibility of using [Ga-68]Ga-FAPI-RGD PET/CT for the detection of lung cancer. The results showed that this method can accurately detect primary lesions with a higher detection rate and improved ability to detect metastases.
Review
Pharmacology & Pharmacy
Jordan Cossu, Fabien Thoreau, Didier Boturyn
Summary: RGD peptides have gained significant attention in the past two decades for their potential in improving tumor therapy by targeting the alpha V beta 3 integrin receptor. This review focuses on the molecular design of multimeric RGD compounds and suitable linkers for drug delivery. The use of RGD constructs in enhancing binding affinity and drug uptake in tumor cells, as well as their potential as theranostic systems, is highlighted. Furthermore, ongoing and future development in comparison with large molecules like monoclonal antibodies is addressed.
Editorial Material
Cardiac & Cardiovascular Systems
Christina Corby-Zauner, Pierre Monney, Matthaios Papadimitriou-Olivgeris, John O. Prior, Christel H. Kamani
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Oncology
Bianca Gautron Moura, Camille L. Gerard, Nathalie Testart, Marian Caikovski, Alexandre Wicky, Veronica Aedo-Lopez, Gregoire Berthod, Krisztian Homicsko, John O. Prior, Clarisse Dromain, Lana E. Kandalaft, Michel A. Cuendet, Olivier Michielin
Summary: In stage IV melanoma, the combination of ipilimumab and nivolumab significantly improves outcomes but has a major financial impact on healthcare. This study analyzes the costs associated with ipilimumab-nivolumab combination, focusing on immune-related adverse events (irAE). Surprisingly, toxicity costs are insignificant compared to the total treatment costs, and patients with higher toxicity grades have lower costs and better outcomes. These findings provide important information for clinicians and healthcare organizations making treatment decisions in immunotherapy.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Joshua Schaefferkoetter, Vijay Shah, Charles Hayden, John O. Prior, Sven Zuehlsdorff
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joshua Schaefferkoetter, Vijay Shah, Charles Hayden, John O. Prior, Sven Zuehlsdorff
Summary: This study presents a deep learning technique for inter-modality, elastic registration of PET/CT images to improve PET attenuation correction. The results demonstrate that this method can effectively reduce artifacts in reconstructed images and has positive effects on applications such as cardiac myocardial perfusion imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior, Judith Anna Delage
Summary: The development of diagnostic and therapeutic radiopharmaceuticals is a hot topic in nuclear medicine. This study focuses on the mice-to-human dosimetry extrapolation of Cu-64/Lu-177 1C1m-Fc anti-TEM-1 for theranostic application in soft-tissue sarcomas. Different dosimetry extrapolation methods were adopted and provided significantly different absorbed doses in organs. The study suggests that further assessments in animal models such as dogs are needed for the therapeutic application before moving into the clinic.
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Lecoq, A. J. Gonzalez, E. Auffray, G. Konstantinou, J. Nuyts, J. O. Prior, R. M. Turtos, J. Varela
Summary: This article summarizes the Fast Timing in Medical Imaging workshop, held in Valencia on June 2, 2022. The workshop brought together 104 attendees from around the world, including representatives from academia and industry. Over the course of three days, medical professionals such as nuclear medicine physicians, radiologists, oncologists, immunologists, and biologists, along with physicists, engineers, technologists, and industry representatives, discussed the importance of improving the timing performance of medical imaging instrumentation. The focus was on positron emission tomography scanners and achieving a 10-ps coincidence time resolution through time-of-flight techniques.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Abler, Roger Schaer, Valentin Oreiller, Himanshu Verma, Julien Reichenbach, Orfeas Aidonopoulos, Florian Evequoz, Mario Jreige, John O. Prior, Adrien Depeursinge
Summary: Background radiomics, a field of image-based computational research, has the potential to revolutionize personalized decision support models. However, the translation of radiomics prediction models into clinical practice is progressing slowly due to the lack of physician involvement and insufficient integration in clinical workflow.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Article
Oncology
Heloise Smet, David Martin, Emilie Uldry, Rafael Duran, Raphael Girardet, Niklaus Schaefer, John O. Prior, Alban Denys, Nermin Halkic, Nicolas Demartines, Emmanuel Melloul
Summary: This study aimed to compare future liver remnant function (FLR-F) assessed by hepatobiliary scintigraphy (HBS) with FLR volume (FLR-V) in predicting posthepatectomy liver failure (PHLF). The study found that FLR function gain after portal vein embolization or liver venous deprivation could predict PHLF effectively.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Marie Nicod Lalonde, Ricardo Dias Correia, Gerasimos P. Syktiotis, Niklaus Schaefer, Maurice Matter, John O. Prior
Summary: Primary hyperparathyroidism (1°HPT) is caused by autonomous secretion of parathormone, which can be treated by parathyroidectomy. Localization of parathyroid adenomas is crucial for surgery planning, and techniques such as cervical ultrasonography and 99mTc-sestamibi scintigraphy are commonly used. 18F-fluoro-choline positron emission tomography/computed tomography (18F-FCH PET/CT) is the most sensitive method for parathyroid adenoma detection.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Rami Hajri, Marie Nicod-Lalonde, Andreas F. F. Hottinger, John O. O. Prior, Vincent Dunet
Summary: The study aimed to evaluate the value of F-18-FET PET/CT via dynamic and texture analyses in predicting the grade and IDH mutation status of untreated gliomas. The results showed that time-activity curve type and texture parameters derived from static analysis had satisfactory-to-good performance in predicting glioma grade, but limited predictive value for IDH status.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bianca Mazini, Matthieu Dietz, Benedicte Marechal, Ricardo Corredor-Jerez, John O. Prior, Vincent Dunet
Summary: This study retrospectively evaluated the interrelation between cardiac and cerebral small-vessel disease (SVD) in 370 patients. The results showed significant interrelations between cardiac and cerebral SVD markers, particularly in terms of deep gray matter alterations.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Jreige, Emeline Darcot, Alban Lovis, Julien Simons, Marie Nicod-Lalonde, Niklaus Schaefer, Flore Buela, Olivier Long, Catherine Beigelman-Aubry, John O. Prior
Summary: The use of high-frequency non-invasive ventilation (HF-NIV) and breath-hold (BH) techniques in PET/CT can improve the detection and texture assessment of lung nodules compared to free-breathing (FB) standard lung CT acquisition. BH and HF-NIV showed comparable performance in texture assessment and outperformed FB in assessing size and volume. BH had better performance in detecting sub-solid nodules compared to HF-NIV and FB.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)
Article
Urology & Nephrology
Marco Altarelli, Mario Jreige, John Olivier Prior, Marie Nicod Lalonde, Antoine Guillaume Schneider
Summary: This study assessed the diagnostic performance of renal scintigraphy (RS) in evaluating the risk of persistent renal failure (PRF) in patients with acute kidney disease (AKD). The results showed that RS-derived parameters had low diagnostic performance, while new parameters obtained within three minutes of injection had comparable diagnostic abilities and improved the performance of the clinical model.
JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Anne-Sophie Lacagne, Laurence May, Marie Nicod Lalonde, John O. Prior, Martin Broome
Summary: This study aims to present the experience with a new diagnostic tool for primary chronic sclerosing osteomyelitis. The combination of three-phase bone scintigraphy and anti-granulocyte antibody scintigraphy can provide a more accurate diagnosis, preventing unnecessary imaging and treatment, and enabling early detection.
Proceedings Paper
Computer Science, Information Systems
Himanshu Verma, Jakub Mlynar, Roger Schaer, Julien Reichenbach, Mario Jreige, John Prior, Florian Evequoz, Adrien Depeursinge
Summary: This study examines the relationship between physicians and artificial intelligence (AI) by interviewing medical imaging experts, and explores the future alignment of AI in clinical and research workflows. The results show that physicians' trust in AI depends not only on their acceptance of AI, but also on their contested experiences with it. The presence of controversy in clinical workflows is crucial for the personal supervision of AI outcomes and processes. Furthermore, tensions in the desired attributes of AI, such as explainability and control, are discussed in the context of divergent intentions and scopes of clinical and research workflows.
PROCEEDINGS OF THE 2023 CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS (CHI 2023)
(2023)
