Synthesis of Novel Nucleoside Analogue Phosphorothioamidate Prodrugs and in vitro Anticancer Evaluation Against RKO Human Colon Carcinoma Cells

Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

(2011) Maurizio Quintiliani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents

(2011) Christine Mara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside

(2011) Christopher McGuigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

(2010) Marco Derudas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

(2010) Youcef Mehellou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties

(2010) Christopher McGuigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4′-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside

(2009) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)

(2009) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

(2009) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

(2009) Youcef Mehellou et al.   ChemMedChem

The Application of Phosphoramidate Protide Technology to Acyclovir Confers Anti-HIV Inhibition

(2009) Marco Derudas et al.   JOURNAL OF MEDICINAL CHEMISTRY