Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 31, Issue 5, Pages 401-410Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2012.665545
Keywords
Breast cancer; RAGE; polymorphism
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Funding
- Zahedan University of Medical Sciences
- Parker B Francis Fellowship in Respiratory Disease
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Several studies have focused on the RAGE genetic background and have demonstrated that its polymorphisms affect the receptor's activity, expression, and downstream signaling. However, there is only little information regarding RAGE polymorphism in breast cancer. In the present study, the authors studied RAGE polymorphisms in 71 patients with breast cancer and 93 healthy women. RAGE-374T/A, -429T/C, and 63 bp Ins/del polymorphisms were analyzed using a hexaprimer amplification refractory mutation system PCR (H-ARMS-PCR). The results showed that RAGE polymorphisms are not associated with breast cancer in the current study population. Larger studies are required to confirm these data in other populations.
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