Article
Multidisciplinary Sciences
Naowanit Nata, Nanthawut Ninwisut, Pitchamon Inkong, Ouppatham Supasyndh, Bancha Satirapoj
Summary: Febuxostat treatment effectively reduces serum uric acid levels in CKD patients and preserves renal function, but does not improve endothelial dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Katsunori Yanai, Keiji Hirai, Shohei Kaneko, Yuko Mutsuyoshi, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita
Summary: We retrospectively analyzed the efficacy and safety of dotinurad, a selective urate reabsorption inhibitor, in hyperuricemic patients with advanced CKD. The results showed that dotinurad was able to decrease uric acid levels and might attenuate renal function decline.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Seokwoo Park, Jung Pyo Lee, Dong Ki Kim, Yon Su Kim, Chun Soo Lim
Summary: This study compared the renoprotective effects of allopurinol and febuxostat on chronic kidney disease and found that allopurinol could slow down the progression of the disease and prevent hypouricemia.
Review
Urology & Nephrology
Hans-Joachim Anders, Qiubo Li, Stefanie Steiger
Summary: Asymptomatic hyperuricaemia (HU) is linked to multiple diseases, but only gouty arthritis and urate nephropathy have proven causative relationships with uric acid crystals. Epidemiological studies show a strong association between HU and hypertension, cardiovascular disease (CVD), and CKD progression, but impaired UA clearance and the use of diuretics likely contribute to these associations. This review provides new insights into the effects of soluble and crystalline UA, discusses the role of asymptomatic HU in CKD, CVD, and sterile inflammation, and identifies areas of research that require further investigation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Pediatrics
Jie Xu, Lingxiao Tong, Jianhua Mao
Summary: This study investigated the clinical characteristics and associated factors of hyperuricemia in Chinese children with chronic kidney disease (CKD). The results showed a significant association between hyperuricemia and kidney risk factors. Monitoring and controlling hyperuricemia, anemia, blood urea nitrogen, and serum creatinine levels in CKD children may help prevent disease progression.
Article
Cardiac & Cardiovascular Systems
Woohyeun Kim, Tae Hwa Go, Dong Oh Kang, Jieun Lee, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dae Ryong Kang, Jang-Young Kim, Eung Ju Kim
Summary: The study investigated the association between uric acid and incident hypertension with a focus on age and sex differences. It found that younger women are at the highest risk of developing uric acid-related incident hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Fengyu Han, Chao Yu, Feng Hu, Wei Zhou, Tao Wang, Linjuan Zhu, Xiao Huang, Huihui Bao, Xiaoshu Cheng
Summary: According to this cross-sectional study, higher SUA levels were positively associated with PAD in male hypertensive patients, while this positive relationship disappeared in female participants.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Fengqin Li, Hui Guo, Jianan Zou, Chensheng Fu, Song Liu, Jing Xiao, Zhibin Ye
Summary: The classification of hyperuricemia (HUA) with chronic kidney disease (CKD) can be varied significantly based on different combinations of parameters such as urinary uric acid excretion rate with uric acid clearance rate or 24-hour urinary uric acid with fractional excretion of uric acid. Further research is needed to determine the most applicable classification method for HUA patients with CKD.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Cheng-Wei Liu, Shin-Rong Ke, Guo-Shiang Tseng, Yen-Wen Wu, Juey-Jen Hwang
Summary: The study found a significant association between hyperuricemia (HUA) and incident hypertension, with each increase in SUA associated with an increased risk of incident hypertension. This association can be explained by a significant correlation of baseline SUA with blood pressure in the following year.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Hui Liu, XiaoLi Song, Jian Zhu, Wei Zhou, Tao Wang, Chao Yu, Lingjuan Zhu, Xiaoshu Cheng, Huihui Bao
Summary: This study found that visceral adiposity index (VAI) is an independent risk factor for hyperuricemia among hypertensive patients. Increased VAI is associated with an increased risk of hyperuricemia in both males and females.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Fuyin Kou, Shanshan Yang, Shengshu Wang, Miao Liu, Yao He
Summary: The average SUA level among centenarians was 329.0±97.75μmol/L, with a prevalence of hyperuricemia at 26.5%. While no significant association was found between SUA levels and hypertension/diabetes, there was an independent positive association with dyslipidemia, particularly with hypertriglyceridemia and low-density lipoprotein cholesterolemia.
Article
Urology & Nephrology
Nathalia Rabello Silva, Camila Evangelista Torres Goncalves, Danilo Lemes Naves Goncalves, Rosangela Minardi Mitre Cotta, Luciana Saraiva da Silva
Summary: Recent studies have found that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than isolated serum uric acid (SUA). In hypertensive patients, elevated levels of isolated SUA were associated with CKD and decreased estimated glomerular filtration rate (eGFR). However, the SUA/SCr was not found to be associated with CKD, indicating that it may not be a reliable predictor in this population.
Article
Biochemistry & Molecular Biology
Ye Chen, Chaoying Pei, Ying Chen, Xiaoyi Xiao, Xingyuan Zhang, Kaiwei Cai, Song Deng, Rongyao Liang, Zhiyong Xie, Pei Li, Qiongfeng Liao
Summary: Kidney tea, a Chinese herbal medicine, can lower uric acid levels and alleviate gout, but the mechanism is not clear. This study investigated the changes in intestinal flora and metabolome to explore the mechanism of kidney tea in lowering uric acid. The results showed that kidney tea significantly reduced serum uric acid levels and mitigated renal damage caused by hyperuricemia. Additionally, kidney tea improved the structure of the intestinal flora and regulated metabolic disorders. These findings provide a theoretical basis for the use of kidney tea as a uric acid-lowering drug.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Letizia Polito, Massimo Bortolotti, Maria Giulia Battelli, Andrea Bolognesi
Summary: This review explores the role of xanthine oxidoreductase (XOR) in the development and progression of chronic kidney disease (CKD). XOR dysregulation may lead to hyperuricemia and oxidative stress, which could have a pathogenic role in the initial phases of CKD. High XOR activity and hyperuricemia are also risk factors for obesity, insulin resistance, type 2 diabetes, and metabolic syndrome.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Hyo-Jung Lee, Ju-Young Choi, Jaeho Lee, Donghoon Kim, Jin-Young Min, Kyoung-Bok Min
Summary: This study revealed a negative association between serum uric acid and serum klotho levels, indicating that an increase in uric acid levels is associated with a decrease in klotho levels.