Article
Clinical Neurology
Sanjiban Chakrabarty, Periyasamy Govindaraj, Bindu Parayil Sankaran, Madhu Nagappa, Shama Prasada Kabekkodu, Pradyumna Jayaram, Sandeep Mallya, Sekar Deepha, J. N. Jessiena Ponmalar, Hanumanthapura R. Arivinda, Angamuthu Kanikannan Meena, Rajan Kumar Jha, Sanjib Sinha, Narayanappa Gayathri, Arun B. Taly, Kumarasamy Thangaraj, Kapaettu Satyamoorthy
Summary: The study conducted comprehensive clinical, pathological, biochemical, and genetic analysis on 11 patients with MELAS syndrome, revealing the classical pathogenic mutation m.3243A > G and mutations in nuclear genes associated with MELAS clinical manifestations.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Tomer Shpilka, YunGuang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, Cole M. Haynes
Summary: The research in C. elegans shows that reduced import of ATFS-1 into mitochondria occurs when mitochondrial proteins are highly expressed, activating the unfolded protein response and causing mitochondrial network expansion.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Katiuska Gonzalez-Arzola, Antonio Diaz-Quintana
Summary: The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Mitochondrial performance relies on a mosaic of nuclear gene products, and their synthesis is regulated by crosstalk between mitochondrial, cytoplasmic, and nuclear factors. Mitochondrial metabolites and proteins can target the cell nucleus and modulate gene expression, chromatin state, and even cause DNA fragmentation in response to stress conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Liying Xue, Jesse D. Moreira, Karan K. Smith, Jessica L. Fetterman
Summary: Nuclear-mitochondrial DNA segments (NUMTs) are fragments of mtDNA that have been inserted into the nuclear genome. They can contaminate mtDNA sequencing results and introduce false positive variants. This review discusses their prevalence, mechanisms of de novo insertion, and approaches for minimizing contamination. Both wet lab-based and computational methods can be used to filter NUMTs, and multiple approaches should be applied for effective identification.
Article
Cell Biology
Rendan Yang, Yamei Li, Yanli Wang, Jingjing Zhang, Qijing Fan, Jianlin Tan, Weizhen Li, Xiaoju Zou, Bin Liang
Summary: This study reveals the role of the DVE-1-NHR-80-lipogenesis axis in mediating the transmission of mitochondrial stress signal to lipid metabolism, highlighting its importance in cellular homeostasis.
Article
Endocrinology & Metabolism
Yuichiro Arima, Yoshiko Nakagawa, Toru Takeo, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda, Tetsushi Sakuma, Takashi Yamamoto, Takehisa Watanabe, Katsuya Nagaoka, Yasuhito Tanaka, Yumiko K. Kawamura, Kazuo Tonami, Hiroki Kurihara, Yoshifumi Sato, Kazuya Yamagata, Taishi Nakamura, Satoshi Araki, Eiichiro Yamamoto, Yasuhiro Izumiya, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Koichi Nishiyama, Naomi Nakagata, Kenichi Tsujita
Summary: Ketogenesis plays a protective role in mitochondrial function during the perinatal period, critical for survival of neonates and infants.
Article
Plant Sciences
Jeffrey P. Mower, Lilly Hanley, Kirsten Wolff, Natalia Pabon-Mora, Favio Gonzalez
Summary: Aragoa, a genus of North Andean plants, is closely related to Littorella and Plantago within the Plantagineae family. Analysis of mitochondrial genomes revealed the sister relationship between Aragoa and Littorella + Plantago. However, conflicting results were found in the placement of P. nubicola within the Plantago genus based on mitochondrial and nuclear data. Extensive substitution rate variation among lineages hindered the resolution of phylogenetic relationships using mitochondrial data.
Article
Plant Sciences
Qing Liu, Hongyu Yuan, Jiaxin Xu, Dongli Cui, Gui Xiong, Trude Schwarzacher, John Seymour Heslop-Harrison
Summary: The study sequenced and analyzed the mitochondrial genome of wild oat, finding complex organization and repeats, as well as homologous sequences with nuclear and chloroplast genomes. This research lays the foundation for oat breeding and exploiting biodiversity within the genus.
Article
Dentistry, Oral Surgery & Medicine
Xin Li, Xin-chan Liu, Xu Ding, Xiao-meng Liu, Niu-ben Cao, Yu Deng, Yu-bo Hou, Wei-xian Yu
Summary: Periodontitis is closely associated with kidney disease and reactive oxygen species involvement. This study found that resveratrol can prevent kidney injury and mitochondrial dysfunction caused by periodontitis.
Review
Biochemistry & Molecular Biology
Margarita A. Sazonova, Vasily V. Sinyov, Anastasia I. Ryzhkova, Marina D. Sazonova, Tatiana V. Kirichenko, Victoria A. Khotina, Zukhra B. Khasanova, Natalya A. Doroschuk, Vasily P. Karagodin, Alexander N. Orekhov, Igor A. Sobenin
Summary: Chronic stress is a combination of nonspecific adaptive reactions of the body to various adverse stress factors, potentially leading to the occurrence of molecular and cellular types of stress. Chronic stress can result in metabolic disturbance, oxidative stress, and mitochondrial dysfunction, which may ultimately lead to the development of neurodegenerative diseases and atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
InHyeok Chung, Han-A Park, Jun Kang, Heyyoung Kim, Su Min Hah, Juhee Lee, Hyeon Soo Kim, Won-Seok Choi, Ji Hyung Chung, Min-Jeong Shin
Summary: The treatment with ATPase inhibitory factor 1 (IF1) protects mitochondria from the effects of Parkinson's disease, showing neuroprotective effects in both cell and animal experiments.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yuting Ji, Dekui Jin, Jingyi Qi, Xuan Wang, Chengying Zhang, Peng An, Yongting Luo, Junjie Luo
Summary: Fucoidan has potent protective effects against DOXO-induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Darren J. Walsh, David J. Bernard, Faith Pangilinan, Madison Esposito, Denise Harold, Anne Parle-McDermott, Lawrence C. Brody
Summary: The analysis of somatic variation in the mitochondrial genome requires deep sequencing of mitochondrial DNA. This study presents a PCR-free method for ultra-deep sequencing coverage of the mitochondrial genome, using isolated intact mitochondria and a sequence-independent approach. The method avoids false-heteroplasmy calls caused by long-range PCR amplification and enables researchers to identify low frequency heteroplasmy without introducing PCR biases or NUMT contamination.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sivaranjani Namasivayam, Rodrigo P. Baptista, Wenyuan Xiao, Erica M. Hall, Joseph S. Doggett, Karin Troell, Jessica C. Kissinger
Summary: The content and structure of mitochondrial genomes vary widely across the eukaryotic tree of life, with protists showing extreme examples. Here, the independent evolution of fragmented cytochrome genes in Toxoplasma and related tissue coccidia, as well as the evolution of a novel genome architecture consisting minimally of 21 sequence blocks totaling 5.9 kb, have been reported. Single-molecule Nanopore reads reveal both whole and fragmented cytochrome genes, while a definitive genome architecture of the mtDNA sequence remains elusive.
Article
Biochemistry & Molecular Biology
Jianmei An, Xiaotian Yin, Ruru Chen, Christopher B. Boyko, Xinming Liu
Summary: Epicaridea is a group of isopods with diverse morphology, reduction and loss of characters, and strong sexual dimorphism. However, the systematic understanding of this group is still incomplete. In this study, mitochondrial and nuclear genes of nine orbionine species were sequenced to investigate their phylogeny. The results showed strong support for a monophyletic Orbioninae and suggested that Epicaridea should be classified as a suborder within Isopoda. The monophyly of Parapenaeon and Orbione is uncertain based on morphological and molecular data. Additionally, the genus Parapenaeon was revised and a new genus Aparapenaeon was established for Parapenaeon japonica and three closely related species.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Ming-Hsiang Lee, Benjamin Siddoway, Gwendolyn E. Kaeser, Igor Segota, Richard Rivera, William J. Romanow, Christine S. Liu, Chris Park, Grace Kennedy, Tao Long, Jerold Chun
Letter
Multidisciplinary Sciences
Ming-Hsiang Lee, Christine S. Liu, Yunjiao Zhu, Gwendolyn E. Kaeser, Richard Rivera, William J. Romanow, Yasuyuki Kihara, Jerold Chun