4.4 Article

Ruthenium-Catalyzed Direct N-Formylation of Lactams with Paraformaldehyde

Journal

SYNLETT
Volume 26, Issue 8, Pages 1077-1080

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378689

Keywords

N-formylation; lactams; ruthenium; paraformaldehyde; N-formylimide; homogeneous catalysis

Funding

  1. professional researcher program through SK Innovation Co., Ltd.
  2. National Research Foundation of Korea (Center for New Directions in Organic Synthesis) [NRF-2014R1A2A1A11050028, 2014R1A5A1011165]

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Catalytic N-formylation of lactams was conducted with paraformaldehyde using Shvo's catalyst. Various lactams were smoothly converted into N-formylimides without the use of a stoichiometric activating reagent.

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