Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer

(2013) Ken-ichi Takayama et al.   EMBO JOURNAL

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

(2013) P. Richard et al.   GENES & DEVELOPMENT

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA

(2013) Milena Preti et al.   NUCLEIC ACIDS RESEARCH

Differential Chemotherapeutic Sensitivity for Breast Tumors With "BRCAness": A Review

(2013) P. Chalasani et al.   ONCOLOGIST

The variety of UV-induced pyrimidine dimeric photoproducts in DNA as shown by chromatographic quantification methods

(2013) Thierry Douki   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

PTB-Associated Splicing Factor (PSF) Is a PPARγ-Binding Protein and Growth Regulator of Colon Cancer Cells

(2013) Tamotsu Tsukahara et al.   PLoS One

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy

(2013) Emil Mladenov et al.   Frontiers in Oncology

CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes

(2012) Dongdong Lu et al.   CANCER CELL

Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

(2012) Alexandre Wagschal et al.   CELL

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA Decapping Factors and the Exonuclease Xrn2 Function in Widespread Premature Termination of RNA Polymerase II Transcription

(2012) Kris Brannan et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Yeast Transcription Termination Factor Rtt103 Functions in DNA Damage Response

(2012) Indukuri Srividya et al.   PLoS One

p54nrb is a new regulator of progression of malignant melanoma

(2011) S. Schiffner et al.   CARCINOGENESIS

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

(2011) Maayan Salton et al.   CELL CYCLE

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

(2011) Lisa Woodbine et al.   NUCLEIC ACIDS RESEARCH

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

End-processing during non-homologous end-joining: a role for exonuclease 1

(2010) K. Bahmed et al.   NUCLEIC ACIDS RESEARCH

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

(2010) Farjana Fattah et al.   PLoS Genetics

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

The impact of heterochromatin on DSB repair

(2009) Aaron A. Goodarzi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

Transcription termination by nuclear RNA polymerases

(2009) P. Richard et al.   GENES & DEVELOPMENT

Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities

(2009) Y. Morozumi et al.   NUCLEIC ACIDS RESEARCH

Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance

(2009) Shuyi Li et al.   NUCLEIC ACIDS RESEARCH

Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor

(2009) Y Lu et al.   ONCOGENE