The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing

The multiple facets of the intra-S checkpoint

(2014) Beáta Grallert et al.   CELL CYCLE

In focus: MLL-rearranged leukemia

(2013) J de Boer et al.   LEUKEMIA

Gli1 Mediates Lung Cancer Cell Proliferation and Sonic Hedgehog-Dependent Mesenchymal Cell Activation

(2013) Olga Bermudez et al.   PLoS One

Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

(2012) S Singh et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

(2012) Andres J. López-Contreras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA replication in early S phase pauses near newly activated origins

(2011) Rebecca A. Frum et al.   CELL CYCLE

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

Distinct proliferative and transcriptional effects of the D-type cyclins in vivo

(2010) Lisa K. Mullany et al.   CELL CYCLE

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

(2010) Han Liu et al.   NATURE

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The S-phase checkpoint: targeting the replication fork

(2009) Mónica Segurado et al.   BIOLOGY OF THE CELL

Chk1–cyclin A/Cdk1 axis regulates origin firing programs in mammals

(2009) Makoto Nakanishi et al.   CHROMOSOME RESEARCH

MDM2 Controls the Timely Expression of Cyclin A to Regulate the Cell Cycle

(2009) R. Frum et al.   MOLECULAR CANCER RESEARCH

Regulation of DNA replication by the S-phase DNA damage checkpoint

(2009) Nicholas Willis et al.   Cell Division

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology