Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway
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Title
Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway
Authors
Keywords
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Journal
NUCLEIC ACIDS RESEARCH
Volume 40, Issue 22, Pages 11270-11280
Publisher
Oxford University Press (OUP)
Online
2012-10-06
DOI
10.1093/nar/gks907
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- (2012) Richard Grondin et al. BRAIN
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- (2011) David K. Stiles et al. EXPERIMENTAL NEUROLOGY
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- (2011) Aurélien Davranche et al. HUMAN MOLECULAR GENETICS
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- (2011) Agnieszka Fiszer et al. NUCLEIC ACIDS RESEARCH
- Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target
- (2011) W. J. Krzyzosiak et al. NUCLEIC ACIDS RESEARCH
- Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing
- (2011) J. A. Broderick et al. RNA
- Huntington's Disease
- (2011) S. Finkbeiner Cold Spring Harbor Perspectives in Biology
- Allele-Selective Inhibition of MutantHuntingtinExpression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat
- (2010) Keith T. Gagnon et al. BIOCHEMISTRY
- Allele-Selective Inhibition of Huntingtin Expression by Switching to an miRNA-like RNAi Mechanism
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- Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
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- Sustained effects of nonallele-specificHuntingtinsilencing
- (2009) Valérie Drouet et al. ANNALS OF NEUROLOGY
- Five siRNAs Targeting Three SNPs May Provide Therapy for Three-Quarters of Huntington's Disease Patients
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- (2009) K. Takimoto et al. RNA
- The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing
- (2009) A. Eulalio et al. RNA
- The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing
- (2009) S. L. Lian et al. RNA
- The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins
- (2009) D. Lazzaretti et al. RNA
- Getting to the Root of miRNA-Mediated Gene Silencing
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