Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

SHIFTX2: significantly improved protein chemical shift prediction

(2011) Beomsoo Han et al.   JOURNAL OF BIOMOLECULAR NMR

Ethionamide Boosters: Synthesis, Biological Activity, and Structure−Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors

(2011) Marion Flipo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of the TetR-like Simocyclinone Efflux Pump Repressor, SimR, and the Mechanism of Ligand-Mediated Derepression

(2011) Tung B.K. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploring Drug Target Flexibility Usingin SituClick Chemistry: Application to a Mycobacterial Transcriptional Regulator

(2010) Nicolas Willand et al.   ACS Chemical Biology

Crystal Structures of the Multidrug Binding Repressor Corynebacterium glutamicum CgmR in Complex with Inducers and with an Operator

(2010) Hiroshi Itou et al.   JOURNAL OF MOLECULAR BIOLOGY

A Comprehensive Analysis of Structural and Sequence Conservation in the TetR Family Transcriptional Regulators

(2010) Zhou Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for the transcriptional regulation of membrane lipid homeostasis

(2010) Darcie J Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tuberculosis pharmacotherapy: strategies to optimize patient care

(2009) Carole D Mitnick et al.   EXPERT OPINION ON PHARMACOTHERAPY

Are we really that good at treating tuberculosis?

(2009) Helen S Cox et al.   LANCET INFECTIOUS DISEASES

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor

(2009) Sean E. Reichheld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA