Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue 17, Pages 5648-5656Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq287
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Funding
- National Institutes of Health [P41HG004118]
- Scientific and Technological Research Council of Turkey [104E049]
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Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes.
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