Journal
SYNLETT
Volume 27, Issue 4, Pages 599-603Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1560976
Keywords
gold; hydroamination; heterocyclization; 2-alkynylanilines; indole
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Funding
- Polish-Singapore Grant 'Green and Sustainable Catalysts for Chemical, Agrochemical and Pharmaceutical Industry' NCBiR [3/3 / ENG-SIN / 2012]
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An efficient heterocyclization of 2-alkynylanilines to indole derivatives has been developed. The reaction proceeds under very mild conditions using small amounts of a gold precatalyst. A range of substrates possessing various functional groups were employed, and the substituted indoles were obtained in very good yields.
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