Review
Pharmacology & Pharmacy
Bayan Sailike, Zhannur Omarova, Janar Jenis, Altynay Adilbayev, Burkitkan Akbay, Sholpan Askarova, Wei-Lin Jin, Tursonjan Tokay
Summary: This review gathers detailed information on the neuroprotective and antiepileptic properties of the genus Artemisia and its potential underlying mechanisms. The extracts from Artemisia species possess antioxidant, anti-inflammatory, anti-apoptotic, anticonvulsant, and pro-cognitive properties, possibly through modulation of mitochondrial ROS production, upregulation of receptor activities, and interference with anti-inflammatory and anti-apoptotic signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Alyson Katz, Shari B. Brosnahan, John Papadopoulos, Sam Parnia, Jason Q. Lam
Summary: Cardiac arrest leads to an imbalance between oxygen supply and demand, resulting in various post-arrest events such as excitotoxicity, mitochondrial dysfunction, oxidative stress, and inflammation. Understanding the complex pathophysiology underlying global brain hypoxic ischemia is crucial in developing neuroprotective strategies to reduce secondary neuronal injury and improve outcomes. Pharmacologic agents like memantine, perampanel, and others may have a potential role in mitigating these injurious pathways post-cardiac arrest.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sakshi Tyagi, Nikhila Shekhar, Ajit Kumar Thakur
Summary: Various pathological conditions lead to protein misfolding, causing loss of neurons and synapses. Capsaicin has been shown to have neuroprotective effects and may be a potential constituent for neuro-pharmacotherapeutics.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Viswanthram Palanivel, Vivek Gupta, Seyed Shahab Oddin Mirshahvaladi, Samridhi Sharma, Veer Gupta, Nitin Chitranshi, Mehdi Mirzaei, Stuart L. Graham, Devaraj Basavarajappa
Summary: This study aimed to investigate the protective effects of Neuropeptide Y (NPY) against glutamate toxicity and ER stress. The results showed that NPY treatment significantly increased cell viability and suppressed apoptosis-related pathways.
Review
Nutrition & Dietetics
Fahimeh Martami, Kathleen F. Holton
Summary: Glutamate plays a significant role in migraines, with excessive levels contributing to excitotoxicity and neuronal injury. Certain nutrients have protective effects against excitotoxicity and can restore glutamate homeostasis.
Article
Agriculture, Multidisciplinary
Rosario Cazares-Camacho, J. Abraham Dominguez-Avila, Humberto Astiazaran-Garcia, Marcelino Montiel-Herrera, Gustavo A. Gonzalez-Aguilar
Summary: The study suggests that mango has potent neuroprotective properties against diabetes-induced oxidative stress, and can be an alternative to prevent and treat biochemical alterations caused by diabetes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Urszula Hohmann, Chalid Ghadban, Tim Hohmann, Joshua Kleine, Miriam Schmidt, Christian Scheller, Christian Strauss, Faramarz Dehghani
Summary: During injuries in the central nervous system, nimodipine, a lipophilic L-type calcium channel blocking agent, has neuroprotective effects on neurons and affects the survival of glia cells. The protective actions of nimodipine are time-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Davoud Malekzadeh, Asadollah Asadi, Arash Abdolmaleki, Gholamreza Dehghan
Summary: This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: This study investigated the potential enhancement of choline activity through association with adaptogen plant extracts. The results showed that the combination of choline with adaptogens can attenuate the effects of oxidative stress and improve memory in chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Miroslaw Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski, Marta Andres-Mach
Summary: This study evaluated the effect of umbelliferone on various antiepileptic drugs and its potential in neuroprotection. The results showed that umbelliferone enhanced the antiepileptic effects of phenobarbital and valproate, and improved the neuroprotective abilities of all the drugs tested.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qi Wang, Dong Lin, Xue-Feng Liu, Fang Dai, Xiao-Jie Jin, Bo Zhou
Summary: Oxidative stress plays a significant role in neurodegenerative diseases. Therefore, developing Nrf2-dependent neuroprotectors is crucial for prevention and treatment. This study utilized an electrophilicity-based strategy to find more active neuroprotectors than natural piperlongumine (PL).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Chunshuai Wu, Jiajia Chen, Chu Chen, Jinlong Zhang, Chao Huang, Zhiming Cui
Summary: Paeoniflorin, a compound extracted from Paeonia lactiflora Pall, has shown preventive and therapeutic effects in various types of nervous system disorders. However, comprehensive knowledge about the pharmacological effects of paeoniflorin on the nervous system is currently not available online. This review summarizes the pharmacological aspects of paeoniflorin and its possible mechanisms, highlighting its potential in the prevention and treatment of disorders like cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, post-traumatic syndrome disorder, and epilepsy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Fahadul Islam, Md Mohaimenul Islam, Atkia Farzana Khan Meem, Mohamed H. Nafady, Md Rezaul Islam, Aklima Akter, Saikat Mitra, Fahad A. Alhumaydhi, Talha Bin Emran, Ameer Khusro, Jesus Simal-Gandara, Aziz Eftekhari, Fatemeh Karimi, Mehdi Baghayeri
Summary: Neurodegenerative diseases (NDDs) are conditions in which the structure and function of neurons deteriorate over time. While genetic alterations can cause NDDs, there are various physiological systems that can trigger neurodegeneration. Oxidative stress has been linked to several NDDs such as Huntington's, Parkinson's, and Alzheimer's. Synthetic drugs are commonly used to treat NDDs but can have side effects. Studies have discovered natural components in plants that can treat NDDs with lesser side effects, such as polyphenols.
Article
Biochemistry & Molecular Biology
Elisa Landucci, Costanza Mazzantini, Daniela Buonvicino, Domenico E. Pellegrini-Giampietro, Maria Camilla Bergonzi
Summary: Experimental evidence shows that TQ can improve cell death induced by KA, reduce excitotoxic injury, and partially rescue the decrease in apoptotic pathways.
Article
Biochemistry & Molecular Biology
Angel Cores, Noelia Carmona-Zafra, Olmo Martin-Camara, Juan Domingo Sanchez, Pablo Duarte, Mercedes Villacampa, Paloma Bermejo-Bescos, Sagrario Martin-Aragon, Rafael Leon, J. Carlos Menendez
Summary: Curcumin analogues with the fragment of piperlongumine showed broad-spectrum activity in the treatment of Alzheimer's disease, with good absorption, antioxidant properties, and the ability to inhibit inflammation.
Article
Ophthalmology
Morteza Seifi, Tim Footz, Sherry A. M. Taylor, Ghada M. Elhady, Ebtesam M. Abdalla, Michael A. Walter
ACTA OPHTHALMOLOGICA
(2016)
Review
Genetics & Heredity
Lance P. Doucette, Michael A. Walter
OPHTHALMIC GENETICS
(2017)
Article
Multidisciplinary Sciences
Morteza Seifi, Michael A. Walter
Article
Multidisciplinary Sciences
Alexandra Rasnitsyn, Lance Doucette, Morteza Seifi, Tim Footz, Vincent Raymond, Michael A. Walter
Article
Biochemistry & Molecular Biology
Lance P. Doucette, Nicole C. L. Noel, Yi Zhai, Manlong Xu, Oana Caluseriu, Stephanie C. Hoang, Alina J. Radziwon, Ian M. MacDonald
Summary: This study focused on inherited retinal dystrophies (IRDs) in ten families from Alberta, Canada, using novel gene discovery methods. The genetic causes of IRDs in three families were identified as variants in known disease-associated genes, while two potential new associations were also found. The research provided interesting insights into blinding conditions and unsolved cases, offering valuable information for further investigation.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Nelly Abdelfatah, Ahmed A. Mostafa, Curtis R. French, Lance P. Doucette, Cindy Penney, Matthew B. Lucas, Anne Griffin, Valerie Booth, Christopher Rowley, Jessica E. Besaw, Lisbeth Tranebjaerg, Nanna Dahl Rendtorff, Kathy A. Hodgkinson, Leichelle A. Little, Sumit Agrawal, Lorne Parnes, Tony Batten, Susan Moore, Pingzhao Hu, Justin A. Pater, Jim Houston, Dante Galutira, Tammy Benteau, Courtney MacDonald, Danielle French, Darren D. O'Rielly, Susan G. Stanton, Terry-Lynn Young
Summary: Otosclerosis is a common form of late-onset hearing impairment with little known about its pathogenesis. A new study identified a FOXL1 gene mutation as a potential cause of autosomal dominant otosclerosis, providing new insights for therapeutic interventions.
Article
Genetics & Heredity
Justin A. Pater, Cindy Penney, Darren D. O'Rielly, Anne Griffin, Lara Kamal, Zippora Brownstein, Barbara Vona, Chana Vinkler, Mordechai Shohat, Ortal Barel, Curtis R. French, Sushma Singh, Salem Werdyani, Taylor Burt, Nelly Abdelfatah, Jim Houston, Lance P. Doucette, Jessica Squires, Fabian Glaser, Nicole M. Roslin, Daniel Vincent, Pascale Marquis, Geoffrey Woodland, Touati Benoukraf, Alexia Hawkey-Noble, Karen B. Avraham, Susan G. Stanton, Terry-Lynn Young
Summary: A new DFNA gene, ATP11A, was identified in a Newfoundland family with bilateral sensorineural hearing loss (SNHL). Two additional families from Israel with similar hearing loss were also found to have a mutation in ATP11A. ATP11A is a type of P4-ATPase gene involved in phospholipid flipping in cell membranes.
Article
Multidisciplinary Sciences
Paul W. Chrystal, Nils J. Lambacher, Lance P. Doucette, James Bellingham, Elena R. Schiff, Nicole C. L. Noel, Chunmei Li, Sofia Tsiropoulou, Geoffrey A. Casey, Yi Zhai, Nathan J. Nadolski, Mohammed H. Majumder, Julia Tagoe, Fabiana D'Esposito, Maria Francesca Cordeiro, Susan Downes, Jill Clayton-Smith, Jamie Ellingford, Omar A. Mahroo, Jennifer C. Hockin, Michael E. Cheetham, Andrew R. Webster, Gert Jansen, Oliver E. Blacque, W. Ted Allison, Ping Yee Billie Au, Ian M. MacDonald, Gavin Arno, Michel R. Leroux
Summary: Motile and non-motile cilia have distinct functions and CFAP20 protein plays a critical role in both types. This study reveals the importance of CFAP20 in maintaining motile cilia function and the structural integrity of non-motile cilia inner junctions.
NATURE COMMUNICATIONS
(2022)
Article
Ophthalmology
Matthew D. Benson, Kimberly M. Papp, Geoffrey A. Casey, Alina Radziwon, Chris D. St Laurent, Lance P. Doucette, Ian M. MacDonald
Summary: This study investigated a patient with PBD caused by defects in PEX6, aiming to understand the disease mechanism and explore the potential therapeutic benefit of overexpressing PEX6. The results showed that mutations in PEX6 led to impaired peroxisomal protein import rather than reduction in peroxisome number, suggesting that introducing wild-type PEX6 into cells deficient in PEX6 protein could restore peroxisome function. Future studies using patient-specific induced pluripotent stem cells may provide more insights into the role of PEX6 in the retina and the potential for gene therapy in these patients.
OPHTHALMOLOGY SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Lance Patrick Doucette, Stephanie Hoang, Alina Radziwon, Ian M. MacDonald
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Lance P. Doucette, Alina Radziwon, Ian M. MacDonald
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Ophthalmology
Lance P. Doucette, Tim Footz, Michael A. Walter
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Ophthalmology
Lance Patrick Doucette, Tim Footz, Michael A. Walter
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2016)