Review
Radiology, Nuclear Medicine & Medical Imaging
Wenzhao Yuan, Qiuyi Yu, Zhen Wang, Jiang Huang, Jienan Wang, Liling Long
Summary: This study conducted a meta-analysis of 13 studies and found that the mean ADC values and ADC ratios before and after neoadjuvant chemotherapy for osteosarcoma were significantly higher in good responders than in poor responders.
ACADEMIC RADIOLOGY
(2022)
Article
Oncology
Wei Zhang, Emma Li, Lily Wang, Brian D. D. Lehmann, X. Steven Chen
Summary: This study aimed to identify genes associated with neoadjuvant chemotherapy (NAC) response and disease-free survival (DFS) of triple-negative breast cancer (TNBC) patients. Large-scale meta-analyses were conducted to identify genes associated with NAC response and survival outcomes. The integration and division of gene associations provided insights into potential NAC response mechanisms and biomarker discovery.
Article
Dermatology
Takeshi Namiki, Moe Makiguchi, Shogo Wada, Hind Al-Busani, Makiko Nishida, Tsukasa Ugajin, Keiko Miura, Kota Yokoyama, Naoko Okiyama
Summary: This article presents a case of squamous cell carcinoma (SCC) arising from extensive pyoderma, which was successfully diagnosed using thallium-201 scintigraphy. Thallium-201 scintigraphy was found to be useful for the diagnosis of SCC by excluding false-positive signals detected by other imaging technologies.
JOURNAL OF DERMATOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Giuseppe Genchi, Alessia Carocci, Graziantonio Lauria, Maria Stefania Sinicropi, Alessia Catalano
Summary: Thallium is a highly toxic heavy metal that can cause various diseases and even death. Its different isotopes have different uses, but due to its high toxicity, it has been used for criminal purposes such as poisoning. Plants and compounds can be used for remediation of thallium contamination in the environment.
APPLIED SCIENCES-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuewen Hao, Rui An, Yingsen Xue, Fan Li, Hong Wang, Jianmin Zheng, Linni Fan, Jixin Liu, Hongbin Fan, Hong Yin
Summary: In osteosarcoma, parameters of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in both tumoral and peritumoral areas can reflect the chemotherapy response and act as prognostic indicators for event-free survival (EFS) and overall survival.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Nicole Bodmer, Stefanie Hecker-Nolting, Godehard Friedel, Claudia Blattmann, Leo Kager, Torsten Kessler, Matthias Kevric Dok, Thomas Kuhne, Vanessa Mettmann, Peter Mueller-Abt, Benjamin Sorg, Matthias Theobald, Stefan S. Bielack
Summary: This study analyzed the clinical characteristics and optimal therapeutic strategies for primary rib osteosarcoma. The results showed that surgery and chemotherapy played a key role in treatment, but negative prognostic factors included incomplete tumor surgery, osteoblastic histology, and poor response to chemotherapy. Early diagnosis and effective local control are crucial for better outcomes.
Review
Medicine, General & Internal
Jun-Ping Yan, Rong-Mei Xiang
Summary: This study investigates the clinical therapeutic effects of combining methotrexate with other chemotherapeutic agents for treating osteosarcoma in children, providing substantial quality evidence for this treatment approach.
Article
Oncology
Stefan S. Bielack, Beate Kempf-Bielack, Guenter Delling, G. Ulrich Exner, Silke Flege, Knut Helmke, Rainer Kotz, Mechthild Salzer-Kuntschik, Matthias Werner, Winfried Winkelmann, Andreas Zoubek, Heribert Juergens, Kurt Winkler
Summary: The study aims to identify prognostic factors for a wide range of osteosarcomas, beyond those typically seen in young patients with localized extremity disease. The analysis of demographic, tumor-related, and treatment-related variables, response, and survival of 1,702 newly diagnosed patients revealed that tumor location and size, primary metastases, response to chemotherapy, and surgical remission are important independent prognostic factors for osteosarcoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Wei Zhong, Wei Luo, Zili Lin, Ziyi Wu, Yuhao Yuan, Yizhe He
Summary: This study compared different surgical and adjuvant treatments for telangiectatic osteosarcoma (TOS) and found that distant metastasis and regional lymph node dissection are associated with poorer outcomes. Limb salvage surgery has similar prognosis to amputation. Neoadjuvant chemotherapy did not significantly improve the prognosis of TOS compared to conventional chemotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Louise Marchandet, Morgane Lallier, Celine Charrier, Marc Baud'huin, Benjamin Ory, Francois Lamoureux
Summary: Osteosarcoma is the most common primary bone tumor affecting children and adolescents, with resistance being one of the reasons for treatment failure. Understanding the molecular mechanisms of resistance is key to developing new strategies to improve patient outcomes.
Article
Biophysics
Esha Baidya Kayal, Devasenathipathy Kandasamy, Kedar Khare, Sameer Bakhshi, Raju Sharma, Amit Mehndiratta
Summary: The study assessed the efficacy of MRI-based statistical texture analysis in predicting chemotherapy response among patients with osteosarcoma. NGTDM features were found to be useful markers in identifying non-survivors, while GLCM, NGTDM, and RLM features were effective markers for predicting chemotherapeutic response.
NMR IN BIOMEDICINE
(2021)
Review
Oncology
L. M. Janssen, B. M. den Dekker, K. G. A. Gilhuijs, P. J. van Diest, E. van der Wall, S. G. Elias
Summary: This meta-analysis demonstrates that the accuracy of MRI for predicting pCR in early-stage breast cancer patients after NAC is influenced by the molecular subtype and MRI field strength.
Article
Endocrinology & Metabolism
Shuier Zheng, Fenglin Wang, Jin Huang, Yan Zhou, Quanjun Yang, Guowei Qian, Chenliang Zhou, Daliu Min, Lele Song, Zan Shen
Summary: The study demonstrated that surgery with sequential chemotherapy and maintenance immunotherapy had a good response for osteosarcoma patients, especially those with high tumor mutation burden lesions and good tolerance for chemotherapy and immunotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Cheng Peng, Zhinan Ren, Jian Zhu, Panke Zhang, Shuyan Cao, Yingjie Hao
Summary: The study aims to examine the clinical therapeutic impacts of combined methotrexate along with other chemotherapeutic agents for treating osteosarcoma in children and young adults. The research will analyze literature from English and Chinese databases, assess bias risks, and evaluate heterogeneity among studies. The results are expected to provide significant evidence and clinical recommendations for the treatment of osteosarcoma.
Article
Multidisciplinary Sciences
Ka Yaw Teo, Ovidiu Daescu, Kevin Cederberg, Anita Sengupta, Patrick J. Leavey
Summary: This study developed a novel classification model for predicting tumor response to neoadjuvant chemotherapy in pediatric patients with osteosarcoma using multi-modal MRI. Different MR image features from different MRI modalities were shown to be significant in distinguishing necrosis from viable tumor. Conventional MRI was effective in differentiating necrosis from viable tumor, with an accuracy averaging above 90%.
