Article
Radiology, Nuclear Medicine & Medical Imaging
Diana Paez, Mike M. Sathekge, Hassan Douis, Francesco Giammarile, Shazia Fatima, Anil Dhal, Sunil K. Puri, Paola A. Erba, Elena Lazzeri, Rodolfo Ferrando, Paulo Almeida Filho, Vincent Peter Magboo, Olga Morozova, Rodolfo Nunez, Olivier Pellet, Giuliano Mariani
Summary: This study aimed to assess the diagnostic performance of MRI, [F-18]FDG PET/CT, and SPECT/CT in patients with suspected postoperative spine infection. The results showed that MRI and [F-18]FDG PET/CT had similarly satisfactory diagnostic performance, with the best performance achieved by combining the results of both modalities. SPECT/CT with Tc-99m-UBI 29-41 performed suboptimally in this clinical setting.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Pharmacology & Pharmacy
Si'an Fang, Yuhao Jiang, Di Xiao, Xuran Zhang, Qianqian Gan, Qing Ruan, Junbo Zhang
Summary: By synthesizing and labeling novel norfloxacin isonitrile derivatives CN4NF and CN5NF, it was found that [Tc-99m]Tc-CN5NF showed high specificity to bacteria, could differentiate bacterial infection from sterile inflammation in vivo, and had the potential to be a radiotracer for bacterial infection imaging.
Article
Chemistry, Medicinal
Anshul Gupta, Rashi Mathur, Sweta Singh, Narmada Bag, Urooj A. Khan, Farhan J. Ahmad, Gamal A. Gabr, Prashant Kesharwani, Gaurav K. Jain
Summary: The methionine-gold nanoparticles (MGNs) showed excellent tumor targeting ability and has promising prospects as a SPECT radiopharmaceutical for imaging tumors.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yuhao Jiang, Si'an Fang, Junhong Feng, Qing Ruan, Junbo Zhang
Summary: To find a new radiotracer for SPECT imaging of bacterial infection with reduced uptake in non-target organs, a novel norfloxacin derivative (HYNICNF) was synthesized and labeled with 99mTc using different coligands. The labeled complexes showed good stability, hydrophilicity, and specific binding to Staphylococcus aureus in vitro. In vivo biodistribution studies in mice with bacterial infection demonstrated that [99mTc]Tc-EDDA-HYNICNF exhibited higher abscess uptake, lower nontarget organ uptake, and the ability to differentiate bacterial infection from sterile inflammation. SPECT imaging in bacterial infection mice confirmed visible accumulation at the infection site, suggesting that [99mTc]Tc-EDDA-HYNICNF is a potential radiotracer for bacterial infection imaging.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Nara Caroline Pereira, Juliana de Oliveira Silva, Frederico B. De Sousa, Sued Eustaquio Mendes Miranda, Daniel Cristian Ferreira Soares, Andre Luis Branco de Barros
Summary: The study successfully radiolabeled phosphate-buffered saline solution with technetium-99m, demonstrating excellent stability and specific bone accumulation, making it a potential selective agent for bone imaging.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Jyotsna Bhatt Mitra, Archana Mukherjee, Anuj Kumar, Ashok Chandak, Sutapa Rakshit, Hansa D. Yadav, Badri Narain Pandey, Haladhar Dev Sarma
Summary: Noninvasive imaging techniques using [Ga-68]Ga-NODAGA-UBI (31-38) have shown promise for early detection of bacterial infections caused by S. aureus. The radiotracer demonstrated high stability and specificity, with targeted localization observed in PET and CLI imaging. This imaging agent holds potential for clinical applications in infection detection.
DRUG DEVELOPMENT RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Christine Farrell, Aparna Balasubramanian, Allison G. Hays, Steven Hsu, Steven Rowe, Stefan L. Zimmerman, Paul M. Hassoun, Stephen C. Mathai, Monica Mukherjee
Summary: Pulmonary hypertension is a serious condition with high morbidity and mortality. Early identification and monitoring of the disease using multimodality imaging can improve outcomes and assess the severity of right ventricular dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Health Care Sciences & Services
Jordy P. Pijl, Thomas C. Kwee, Riemer H. J. A. Slart, Andor W. J. M. Glaudemans
Summary: PET/CT is increasingly used in infectious diseases for its ability to diagnose infections based on glucose consumption. Advances in PET/CT technology, such as total body scanning and new radiotracers, are expected to enhance personalized treatment capabilities for infectious diseases in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yu Zhang, Zhiyi Lin, Tao Li, Yongbao Wei, Mingdian Yu, Liefu Ye, Yuqing Cai, Shengping Yang, Yanmin Zhang, Yuanying Shi, Wenxin Chen
Summary: According to a prospective study, Tc-99m-PSMA SPECT/CT is superior to Tc-99m-MDP SPECT/CT in detecting bone metastases in prostate cancer, especially for small lesions and patients with low PSA levels, and provides additional information on extraskeletal metastases.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Emma J. Laws, Lluis Sanchez, Elsa Beltran, Elisabet Dominguez, Abel B. Ekiri, Josep Brocal, Luisa De Risio
Summary: This multicenter retrospective study aimed to describe the clinical presentation and outcome of dogs undergoing spinal surgery or conservative management for canine spinal epidural empyema (SEE). The study found that there was no significant difference in long-term outcome between conservatively and surgically treated dogs, although more surgically treated dogs were non-ambulatory at presentation. Age may serve as a negative prognostic indicator for long-term outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Oncology
Saskia Litiere, Jan Bogaerts
Summary: The translation article introduces the importance and challenges of the Response Evaluation Criteria in Solid Tumors (RECIST) in clinical trials, as well as attempts to update and replace the criteria. The article emphasizes the value and goals of RECIST as a standardized tool, mentions issues in immunotherapy and PET imaging, and states that efforts are being made to address these issues.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cardiac & Cardiovascular Systems
Nobuhiro Tahara, Olivier Lairez, Jin Endo, Atsushi Okada, Mitsuharu Ueda, Tomonori Ishii, Yoshinobu Kitano, Hahn-Ey Lee, Eleonora Russo, Toru Kubo
Summary: The Tc-99m-labelled bone radiotracer scintigraphy is an effective diagnostic method for early detection of ATTR-CM, with high sensitivity and specificity. However, the adoption of this technique for early diagnosis in daily clinical practice by general cardiologists is still limited, highlighting the need for guidance and education in this area.
Article
Biochemistry & Molecular Biology
Yongkyoung Kweon, Ji-Yong Park, Young-Joo Kim, Yun-Sang Lee, Jae-Min Jeong
Summary: This study demonstrates the detection of endogenous hydrogen sulfide generated in hypoxic tissue using [Tc-99m]Tc-gluconate, a novel imaging agent that can be used both in vitro and in vivo.
Article
Surgery
Sheila Stallard, Francesca Savioli, Alex McConnachie, John Norrie, Katie Dudman, Elizabeth S. Morrow, Laszlo Romics
Summary: This study found that a single dose of prophylactic antibiotic in breast cancer surgery did not show any benefit, indicating that antibiotics may not be necessary for these surgeries.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Ayman Abouzayed, Jesper Borin, Fanny Lundmark, Anastasiya Rybina, Sophia Hober, Roman Zelchan, Vladimir Tolmachev, Vladimir Chernov, Anna Orlova
Summary: A kit was successfully prepared for prospective use in an early-phase clinical study, allowing for one-pot single-step radiolabeling with technetium-99m. The radiolabeled peptide maintained its binding properties and showed good safety in animal models after 18 months of storage. Therefore, the prepared kit can be further evaluated for clinical application.