Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 41, Issue 1, Pages 102-105Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2013.08.008
Keywords
Dosimetry; Positron emission tomography; [C-11]FLB 457; Dopamine D-2 receptors
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Health Labour Sciences Research grant from the Ministry of Health, Labour and Welfare, Japanese government
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Purpose: [C-11]FLB 457, a radioligand with very high affinity and selectivity for dopamine D-2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [C-11]FLB 457 in healthy human subjects. Methods: Whole-body images were acquired for 2 h after an injection of [C-11]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software. Results: Organs with the longest residence time were the liver, lungs, and brain. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [C-11]FLB 457 is 5.9 mu Sv/MBq, similar to those of other C-11-labeled tracers. Conclusions: This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended-dose guidelines in the USA and Europe. (C) 2014 Elsevier Inc. All rights reserved.
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