Article
Multidisciplinary Sciences
Yong-Jin Park, Ji Won Lee, Hee Won Cho, Yearn Seong Choe, Kyung-Han Lee, Joon Young Choi, Ki Woong Sung, Seung Hwan Moon
Summary: The study aimed to investigate the value of C-11 methionine positron emission tomography/computed tomography (MET PET/CT) in patients with intracranial germinoma (IG). The findings showed that MET PET/CT could be a useful diagnostic tool for IGs and that tumor MET avidity may serve as a potential surrogate biomarker for HCG.
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Biochemistry & Molecular Biology
Rongmei Tang, Yongkang Gai, Kun Li, Fan Hu, Chengpeng Gong, Sheng Wang, Fei Feng, Bouhari Altine, Jia Hu, Xiaoli Lan
Summary: A novel carbon-11 radiolabeled molecular probe C-11-methoxy-OTSSP167 was successfully synthesized and exhibited elevated uptake in MELK overexpressed tumors, showing potential for noninvasive imaging of TNBC. This tracer had high radiochemical purity and specifically targeted triple-negative breast cancers.
BIOORGANIC CHEMISTRY
(2021)
Article
Neurosciences
Raphael Sura Daveau, Ian Law, Otto Molby Henriksen, Steen Gregers Hasselbalch, Ulrik Bjorn Andersen, Lasse Anderberg, Liselotte Hojgaard, Flemming Littrup Andersen, Claes Nohr Ladefoged
Summary: The study demonstrates that using activity reduction and AI-assisted denoising in PET scans can successfully reduce image noise, improve visual quality, and maintain stability of clinical metrics.
Article
Oncology
Matteo Donadon, Egesta Lopci, Jacopo Galvanin, Simone Giudici, Daniele Del Fabbro, Ezio Lanza, Vittorio Pedicini, Arturo Chiti, Guido Torzilli
Summary: The study investigates the clinical impact of C-11-choline positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC) patients undergoing hepatectomy. Results show that Barcelona stages and metabolic tumor volume (MTV) are independently associated with overall survival. Incorporating C-11-choline PET/CT into the HCC staging system may provide better prognostic refinement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Jannusch, Nils Martin Bruckmann, Janna Morawitz, Matthias Boschheidgen, Harald H. Quick, Ken Herrmann, Wolfgang P. Fendler, Lale Umutlu, Martin Stuschke, Boris Hadaschik, Gerald Antoch, Lars Schimmoeller, Julian Kirchner
Summary: Combined assessment of Ga-68-PSMA-11 PET/MRI improves tumor localization in men with biochemical recurrence. The MRI detected local recurrence of PCa more often whereas (68) Ga-PSMA-11 PET detected lymph node metastases more often, especially for PSA < 1.69 ng/mL.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Dawei Sun, Juan Liu, Yunfang Wang, Jiahong Dong
Summary: This study investigates the mechanism and novel treatments of lenvatinib resistance in hepatocellular carcinoma (HCC). It shows that inhibiting MDR1 and BCRP transporters or targeting the EGFR/PI3K pathway can overcome lenvatinib resistance in HCC. Additionally, lenvatinib plays an important role in inhibiting tumor growth and angiogenesis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Fabio Bioletto, Marco Barale, Mirko Parasiliti-Caprino, Nunzia Prencipe, Alessandro Maria Berton, Massimo Procopio, Desiree Deandreis, Ezio Ghigo
Summary: This study compared the diagnostic accuracy of C-11-Methionine and F-18-Fluorocholine PET for parathyroid localization in primary hyperparathyroidism patients for the first time. The findings suggested that F-18-Fluorocholine had superior sensitivity compared to C-11-Methionine, while both tracers had similar positive predictive value.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Birgit Pernthaler, Tina Nazerani Hooshmand, Jasminka Igrec, Herbert Kvaternik, Reingard M. Aigner
Summary: Prostate cancer is a common cancer in men with high recurrence rate, and Ga-68-PSMA-11 and F-18-fluciclovine are PET imaging tracers used to detect recurrence sites. In a case study, an 83-year-old man with known oligodendroglioma and biochemically recurrent PC showed high focal uptake of Ga-68-PSMA-11 and F-18-fluciclovine in the brain.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qian Zhao, Hui Dong, Aisheng Dong, Changjing Zuo
Summary: We present a case of rectal linitis plastica secondary to prostate adenocarcinoma, and describe the MRI, Ga-68-PSMA-11 PET/CT, and PET/MRI findings. The rectal linitis plastica was the initial manifestation of the prostate adenocarcinoma, with the rectum being the sole site of metastasis. Imaging showed circumferential thickening of the rectal wall on MRI, and intense Ga-68-PSMA-11 uptake on PET/CT and PET/MRI. Familiarity with these imaging features can aid in the recognition of this rare condition.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrei Gafita, Hui Wang, Andrew Robertson, Wesley R. Armstrong, Raphael Zaum, Manuel Weber, Farid Yagubbayli, Clemens Kratochwil, Tristan R. Grogan, Kathleen Nguyen, Fernando Navarro, Rouzbeh Esfandiari, Isabel Rauscher, Bjoern Menze, David Elashoff, Ebrahim S. Delpassand, Ken Herrmann, Johannes Czernin, Michael S. Hofman, Jeremie Calais, Wolfgang P. Fendler, Matthias Eiber
Summary: We systematically determined the impact of tumor burden on Ga-68-PSMA PET biodistribution using quantitative measurements. The study found that patients with a very high tumor load showed significantly lower uptake of Ga-68-PSMA in normal organs, which could have implications for PSMA-targeted radioligand therapy.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Plant Sciences
Mathiyazhagan Narayanan, Arivalagan Pugazhendhi, Ying Ma
Summary: The study explored the plant growth-promoting traits of metal-tolerant Bacillus cereus NDRMN001 and their impact on the physiology and phytoremediation potential of Cajanus cajan (L.) Millsp. on metal-polluted soil. It was found that the PGP activities of B. cereus NDRMN001 significantly enhanced plant growth and remediation efficiency in metal-polluted soil.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Oncology
P. A. Glemser, L. T. Rotkopf, C. H. Ziener, B. Beuthien-Baumann, V Weru, A. Kopp-Schneider, H. P. Schlemmer, A. Dimitrakopoulou-Strauss, C. Sachpekidis
Summary: [Ga-68]PSMA-11 PET-CT and PET-MRI provide equally good detection rates for prostate cancer recurrence, both outperforming stand-alone MRI. PET-MRI is particularly efficient in detecting local recurrences in the prostate bed, while there were no significant differences in lesion detection rate between PET-CT and PET-MRI. The probability of a positive scan significantly increased with increasing PSA levels for all imaging modalities.
Review
Oncology
Ruizhe Huang, Yizhen Li, Haowen Wu, Boyi Liu, Xuanjun Zhang, Zhongxi Zhang
Summary: The aim of this study was to compare the diagnostic efficacy of Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI in patients with biochemically recurrent prostate cancer. A meta-analysis and systematic review were conducted, analyzing 37 studies involving 8409 patients. The results showed that Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI had similar detection rates for biochemically recurrent prostate cancer. However, larger prospective studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Yuko Koshimori, Michael D. Cusimano, Erica L. Vieira, Pablo M. Rusjan, Stephen J. Kish, Neil Vasdev, Sho Moriguchi, Isabelle Boileau, Thomas Chao, Zahra Nasser, M. Ishrat Husain, Khunsa Faiz, Joeffre Braga, Jeffrey H. Meyer
Summary: Traumatic brain injury (TBI) is common, but the reason behind persisting symptoms in some patients is unknown. Astrogliosis, a response to brain injury, may be a potential therapeutic target, but its presence in TBI patients with persistent symptoms has not been confirmed.