Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xiyi Qin, Han Jiang, Yu Liu, Hong Zhang, Mei Tian
Summary: Apoptosis is a natural, non-inflammatory form of programmed cell death that can be detected through characteristic biochemical changes. Imaging with radionuclide tracers allows for selective detection of apoptotic cell death in vivo, potentially serving as diagnostic markers, early-response indicators, and prognostic predictors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Oncology
Huiling Li, Zhen Liu, Lujie Yuan, Kevin Fan, Yongxue Zhang, Weibo Cai, Xiaoli Lan
Summary: Breast cancer is a common malignant tumor that affects women globally, posing a significant threat to their health. Early detection of breast cancer can greatly improve patient prognosis and survival rates, with radionuclide molecular imaging techniques offering advantages in functional detection. Using radionuclide-labeled compounds for noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualizing overexpressed molecular markers in the disease, aiding in early diagnosis and improved patient care. Rapid developments in radionuclide probes are contributing to the diagnosis of breast cancer across various aspects, with promising tools being developed for early detection.
Article
Medicine, General & Internal
Mitchel R. Stacy
Summary: Peripheral arterial disease (PAD) is a non-coronary artery atherosclerotic disorder that affects the lower extremities and is associated with various health consequences. The diagnosis is typically made using non-invasive tests, but nuclear medicine techniques have recently emerged as a potential tool for assessing the functional consequences of PAD-related limb ischemia.
FRONTIERS IN MEDICINE
(2022)
Article
Computer Science, Information Systems
Maria Filomena Santarelli, Anna Mori, Michelangelo Bertasi, Vincenzo Positano, Alessia Gimelli, Michele Scipioni, Paolo Marzullo, Luigi Landini
Summary: A comparison was made between a dedicated cardiac SPECT system and a general-purpose SPECT system, evaluating their hardware differences and image quality through specific indices. The dedicated cardiac SPECT system showed superior performance in cardiac imaging, but was only suitable for patients with a low body mass index; whereas the general-purpose system could be used for various anatomical regions and patient types.
Article
Psychiatry
Daniel G. Amen, Theodore A. Henderson, Andrew Newberg
Summary: Brain perfusion SPECT imaging can distinguish between ADHD patients and healthy controls, with specific brain regions showing potential as biomarkers to reliably differentiate ADHD.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Mari Nakaie, Fumihiro Katayama, Takehiro Nakagaki, Sakura Yoshida, Masao Kawasaki, Kodai Nishi, Kazuma Ogawa, Akira Toriba, Noriyuki Nishida, Morio Nakayama, Takeshi Fuchigami
Summary: The researchers designed and synthesized a novel single-photon emission computed tomography probe for the detection of cerebral PrPSc deposits. The probe showed high binding affinity to PrPSc and remarkable selectivity against other aggregates. In vivo and in vitro experiments demonstrated its potential imaging applications.
ACS INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Atsushi Yagishita, Shin'ichiro Takeda, Kazunobu Ohnuki, Miho Katsuragawa, Oltea Sampetrean, Hirofumi Fujii, Tadayuki Takahashi
Summary: In this study, we developed a high-spatial-resolution and high-energy-resolution small animal SPECT scanner called CdTe-DSD SPECT-I. Using this scanner, we achieved successful multi-tracer SPECT imaging of submillimetre targets and dual-tracer in vivo imaging of submillimetre metastatic lesions, producing clear and quantitative images.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Wen, Hongming Zhuang, Jigang Yang
Summary: The purpose of this study was to determine if the image acquisition time for the salivagram can be shortened without significantly reducing the sensitivity in detecting aspiration. It was found that evidence of aspiration could be detected within the first 40 minutes of dynamic imaging, therefore the originally described 60-minute protocol can be safely shortened to 40 or even 30 minutes.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Oncology
Nasim Vahidfar, Saeed Farzanefar, Hojjat Ahmadzadehfar, Eoin N. Molloy, Elisabeth Eppard
Summary: This literature review provides a brief overview of the role of nuclear medicine in the diagnosis of obstetric and gynecological cancers. Nuclear medicine has proven to be reliable in diagnostic imaging in nuclear medicine and cancer treatment. [F-18]FDG PET/CT imaging plays a crucial role in investigating gynecological cancer.
Review
Biochemistry & Molecular Biology
Krystyna Pyrzynska, Krzysztof Kilian, Mateusz Pegier
Summary: This paper provides a brief overview of the application of porphyrin ligands in tumor diagnostics, including the chelation of metallic radioisotopes to form radiopharmaceuticals and the evaluation of metabolic changes in the human body through SPECT and PET. The chelation reactions are discussed in terms of the conditions, kinetics, and complex stability.
Review
Oncology
Liming Xiao, Jun Xin
Summary: This review provides an overview of the current clinical research progress and application value of (99m)-3PRGD2 SPECT imaging for tumor lesions, as well as discusses the future clinical application prospects and possibilities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Winn Aung, Atsushi B. Tsuji, Aya Sugyo, Masayuki Fujinaga, Ming-Rong Zhang, Tatsuya Higashi
Summary: Photoimmunotherapy (PIT) combined with chemotherapy shows improved efficacy in cancer treatment. By evaluating the super-enhanced permeability and retention effect of different molecular weight drugs, promising candidates for combined PIT treatment were identified, leading to increased drug accumulation in tumors. Further preclinical and clinical studies are encouraged to develop combination therapy of PIT with conventional anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuying Li, Kaixiang Zhou, Wentao Guo, Mengchao Cui
Summary: This study focused on designing 2-phenylbenzoheterocycles with chiral dihydroxyl side chains as beta-amyloid imaging probes, which exhibited good binding affinities and improved brain kinetics compared to existing derivatives. The (S, R)-[F-18]14 probe showed high affinity and specificity to A beta plaques, making it a promising potential PET imaging probe for early diagnosis of Alzheimer's disease.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Longfei Zhang, Xin Gong, Chuan Tian, Hualong Fu, Hongwei Tan, Jiapei Dai, Mengchao Cui
Summary: This study designed a new series of near-infrared probes with different numbers of conjugated triple bonds for efficient detection of A beta plaques.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Medicine, Research & Experimental
Kaixiang Zhou, Fan Yang, Yuying Li, Yimin Chen, Xiaojun Zhang, Jinming Zhang, Junfeng Wang, Jiapei Dai, Lisheng Cai, Mengchao Cui
Summary: This study evaluated three pairs of optically pure F-18-labeled 2-phenylquinoxaline derivatives as potential Tau imaging agents for AD diagnosis, showing high selectivity and affinity for Tau tangles over A beta. The PET probes (R)-[F-18]5 and (S)-[F-18]16 demonstrated promising brain penetration, kinetics, and stability, making them suitable candidates for Tau tangle imaging.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Xiaojun Zhang, Yitian Wu, Qi Zeng, Tianxin Xie, Shulin Yao, Jinming Zhang, Mengchao Cui
Summary: The study designed, synthesized, and evaluated three more lipophilic F-18-labeled PSMA tracers, investigating the effect of lipophilicity on their distribution and excretion in different species. Higher lipophilicity led to increased radioactivity accumulation in the liver of primates and humans, as well as reduced excretion to the bladder through urine. The screened tracer [F-18]8c showed low bladder retention and good imaging properties in patients with prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Longfei Zhang, Xiaojing Shi, Yuying Li, Xiaojiang Duan, Zeyu Zhang, Hualong Fu, Xing Yang, Jie Tian, Zhenhua Hu, Mengchao Cui
Summary: A novel probe PSMA-1092 with high affinity for PSMA was developed for precise tumor resection in radical prostatectomy, showing excellent performance in delineating tumor margin and detecting residual tumors in real-time NIR-II imaging, offering promising potential for clinical practice.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Tao Wang, Xiaojun Zhang, Winnie Deuther-Conrad, Hualong Fu, Mengchao Cui, Jinming Zhang, Peter Brust, Yiyun Huang, Hongmei Jia
Summary: In this study, a series of indole-based derivatives were synthesized as novel sigma-2 receptor ligands, and two ligands with high affinity and selectivity were radiolabeled with F-18. Biodistribution studies in rodents showed that the radioligand [F-18]9 displayed high brain uptake and brain-to-blood ratio. Pre-treatment experiments and ex vivo autoradiography confirmed the specific binding of [F-18]9 to sigma-2 receptors in the brain. Dynamic positron emission tomography imaging further confirmed the regional distribution and specific binding of [F-18]9 in the rat brain.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Wang, Li Cai, Kaixiang Zhou, Mengchao Cui, Shaobo Yao
Summary: This study reported a fully automated radiosynthetic procedure of a novel tau tracer [F-18]-S16 and evaluated its safety, biodistribution, and dosimetry in healthy volunteers as well as its potential utility in Alzheimer's disease (AD). The results showed that [F-18]-S16 could be synthesized automatically with favorable biodistribution and safety in humans. [F-18]-S16 PET demonstrated high image quality for imaging tau deposition in AD and distinguishing AD from healthy controls.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Wei Dong, Meng-Chao Cui, Wen-Zheng Hu, Qi Zeng, Yi-Long Wang, Wei Zhang, Yue Huang
Summary: SQSTM1/p62 plays an important role in the progression of Alzheimer's disease (AD) through its associations with A beta(42) levels in cerebrospinal fluid (CSF) and A beta deposition in the brain of AD patients, as revealed by genetic associations and immunoreactivity analysis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yuying Li, Tianqing Liu, Mengchao Cui
Summary: This review summarizes the latest development of Tau tracers and analyzes their chemical structures and biological properties. The limitations of current tracers and considerations for the development of new tracers are also discussed.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Qi Zeng, Yimin Chen, Yingying Yan, Rong Wan, Yanjing Li, Hualong Fu, Yu Liu, Sen Liu, Xiao-Xin Yan, Mengchao Cui
Summary: By rational design, a series of D-pi-A-based trisubstituted alkenes were developed, which showed high binding affinities to alpha-syn fibrils and promising potential for the in vitro neuropathological staining of Lewy pathologies.
ANALYTICAL CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Liping Fu, Jinming Zhang, Kaixiang Zhou, Xiaojun Zhang, Hengge Xie, Mingwei Zhu, Mengchao Cui, Ruimin Wang
Summary: This study evaluates the effectiveness of a new tracer, [F-18]-S16, in distinguishing patients with AD from HCs. The results show that [F-18]-S16 exhibits increased cortical uptake in AD patients, suggesting its potential for in vivo detection of tau protein.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Tianxin Xie, Yuying Li, Chuan Tian, Chang Yuan, Bin Dai, Shubo Wang, Kaixiang Zhou, Jiaqi Liu, Hongwei Tan, Yi Liang, Jiapei Dai, Baian Chen, Mengchao Cui
Summary: This study developed a novel probe TNIR7-1A that can selectively detect NFTs and clearly distinguish tauopathy from the control group in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
Summary: We have discovered and developed a class of diaryl-azine derivatives for detecting Afi plaques in the AD brain using PET imaging. After comprehensive assessments, we identified a promising Afi-PET tracer, [18F]92, with high binding affinity to Afi aggregates, significant binding ability with AD brain sections, and optimal brain pharmacokinetic properties. The first in-human PET study showed that [18F]92 displayed low white matter uptake and could bind to Afi pathology for distinguishing AD from healthy controls, making it a promising PET tracer for visualizing Afi pathology in AD patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xu Zhou, Lin-Lin Dong, Yuying Li, Meng-Chao Cui, Lang-Tao Shen
Summary: Prostate-specific membrane antigen (PSMA) is a significant target for prostate cancer diagnosis and therapy. The combination of DUPA with a multidentate bifunctional chelator successfully targets PSMA and forms a new precursor for gallium-68 radiopharmaceutical, DUPA beta-Ala-KC18. This novel compound displays binding affinity to PSMA.
RESULTS IN CHEMISTRY
(2021)
