Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 35, Issue 2, Pages 239-244Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2007.11.003
Keywords
[F-18]FDG; CIDG; 1-phenyl-3-methyl-5-pyrazolone (PMP); quality control; Kryptofix 2.2.2
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A practical, sensitive and rapid analytical method was established and validated for chemical impurity tests of 2-deoxy-2-fluoro-D-glucose (FDG), 2-deoxy-2-chloro-D-glucose (CIDG) and Kryptofix 2.2.2 (K-222) in [F-18]FDG. This method was based on precolumn derivatization with ultraviolet (UV) detection. FDG and CIDG were rapidly derivatized with 1-phenyl-3-methyl-5-pyrazolone in the presence of borate buffer at 40 degrees C, and the labeled derivatives and K-222 were separated by reversed-phase high-performance liquid chromatography and monitored by IN absorbance at 210 nm. After optimization of the conditions, FDG, CIDG and K-222 could be determined within 15 min and showed good performance in terms of sensitivity, linearity and reproducibility. This method could be successfully applied to the quality control test of [F-18]FDG produced by a commercially available apparatus. (c) 2008 Elsevier Inc. All rights reserved.
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