Article
Radiology, Nuclear Medicine & Medical Imaging
D. Mazzucconi, D. Bortot, A. Pola, A. Fazzi, L. Cazzola, V Conte, G. A. P. Cirrone, G. Petringa, G. Cuttone, L. Manti, S. Agosteo
Summary: The NEPTUNE project aims to investigate the increase of proton-induced cytogenetic effects in cells irradiated in the presence of an agent containing natural boron. Experimental results show the presence of alpha particles from both boron neutron capture and proton boron fusion reactions. The study demonstrates that low energy and high-linear energy transfer particles from these reactions can be measured, although a reliable quantitative study of the alpha production rate has not been achieved yet.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Biology
Sergey Taskaev, Evgenii Berendeev, Marina Bikchurina, Timofey Bykov, Dmitrii Kasatov, Iaroslav Kolesnikov, Alexey Koshkarev, Aleksandr Makarov, Georgii Ostreinov, Vyacheslav Porosev, Sergey Savinov, Ivan Shchudlo, Evgeniia Sokolova, Igor Sorokin, Tatiana Sycheva, Gleb Verkhovod
Summary: A compact neutron source has been proposed and created at the Budker Institute of Nuclear Physics in Novosibirsk, Russia, capable of producing high neutron flux for boron neutron capture therapy. Several scientific research activities, including BNCT technique testing and dosimetry method development, have been conducted at the facility. Future plans include certification of the neutron source and clinical trials, with the prototype serving as a basis for a facility in Xiamen (China).
Article
Instruments & Instrumentation
Shogo Honda, Sachiko Yoshihashi, Seinosuke Tomita, Kazuki Tsuchida, Yoshiaki Kiyanagi, Yukio Tsurita, Kenichi Watanabe, Atsushi Yamazaki, Akira Uritani
Summary: Nagoya University is developing a new concept of sealed lithium target for an accelerator-driven neutron source for Boron neutron capture therapy. Test samples were prepared to evaluate the performance of the sealed Li target in the study.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Nuclear Science & Technology
Ezddin Hutli, Peter Zagyvai
Summary: This article presents experiments on Boron Neutron Capture Therapy (BNCT) conducted at the Institute of Nuclear Techniques (INT), Budapest University of Technology and Economics (TUB). The investigations were aimed at designing BNCT for vivo applications and included studying the properties of boron compounds and neutron beams. Various carrier materials and detection methods were employed to measure particle attenuation and emitted charged particles. The results suggest that a new approach is needed to accurately determine the radiation dose from the 10B (n,a) reaction.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Oncology
Liisa Porra, Lauri Wendland, Tiina Seppala, Hanna Koivunoro, Hannu Revitzer, Jussi Tervonen, Leena Kankaanranta, Anu Anttonen, Mikko Tenhunen, Heikki Joensuu
Summary: The authors reviewed the results of 249 patients treated with boron neutron capture therapy (BNCT) at Helsinki University Hospital, Finland. They found that BNCT using l-boronophenylalanine-fructose (l-BPA-F) as the boron delivery agent was well tolerated and showed efficacy in the treatment of head and neck cancer and malignant glioma. They also described a new hospital BNCT facility that integrates a proton accelerator-based neutron source for treatment planning and positioning.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Instruments & Instrumentation
Shogo Honda, Sachiko Yoshihashi, Yukinori Hamaji, Jingjie Shen, Kazuki Tsuchida, Takeo Nishitani, Yoshiaki Kiyanagi, Yukio Tsurita, Kenichi Watanabe, Atsushi Yamazaki, Akira Uritani
Summary: An accelerator-driven neutron source using a thick lithium target and copper-lithium alloy to improve heat removal performance has been developed. Experimental results confirmed the contribution of the copper-lithium alloy and indicated that stopping protons in the lithium layer does not cause degradation in performance.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Chemistry, Inorganic & Nuclear
Shunsuke Suzuki, Kazunori Nitta, Takayuki Yagihashi, Paul Eide, Hanna Koivunoro, Naoki Sato, Shinichi Gotoh, Shintaro Shiba, Motoko Omura, Hironori Nagata, Hiroki Tanaka
Summary: An accelerator-based boron neutron capture therapy (AB-BNCT) system was successfully installed at Shonan Kamakura General Hospital (SKGH), which demonstrated stable operation for 1 hour at a current of 30 mA. The measured thermal neutron flux of 2.8 x 109 cm-2 s-1 agreed well with the calculated values, within a deviation of ±5%. The ambient dose rate due to residual radioactivity after irradiation was approximately 5 μSv/h with the use of a lead shutter.
APPLIED RADIATION AND ISOTOPES
(2023)
Article
Pharmacology & Pharmacy
Alexander Zaboronok, Polina Khaptakhanova, Sergey Uspenskii, Raman Bekarevich, Ludmila Mechetina, Olga Volkova, Bryan J. Mathis, Vladimir Kanygin, Eiichi Ishikawa, Anna Kasatova, Dmitrii Kasatov, Ivan Shchudlo, Tatiana Sycheva, Sergey Taskaev, Akira Matsumura
Summary: This article introduces the use of boron nanoparticles as a core component of a novel boron drug for boron neutron capture therapy (BNCT) and compares its effectiveness with the clinically registered drug, borophenylalanine (BPA), on tumor cells. The study shows that the boron nanoparticles significantly reduce the colony-forming capacity of tumor cells in BNCT experiments. Further research is needed to optimize the tumor-targeting properties of these nanoparticles and conduct in vivo experiments.
Article
Instruments & Instrumentation
Zhaopeng Qiao, Baolong Ma, Bo Rong, Quanxu Jiang, Sheng Wang
Summary: This paper presents the design and parameter calculation of an AB-BNCT facility based on the Li(p,n) reaction. The effects of reflector materials, rotation gap, and moderator in the beam shaping assembly (BSA) are discussed. The influence of the density of magnesium fluoride blocks on the outgoing neutron beam is analyzed in detail, and the therapeutic potential of the epithermal neutron beam is evaluated using water and Snyder phantom. It is concluded that a 20 cm lead reflector, a 6 cm rotation gap, and a density of magnesium fluoride blocks above 2.5 g/cm3 can meet the treatment needs, while a density of 2.8 g/cm3 is a compromise choice considering processing difficulty and cost.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2023)
Article
Instruments & Instrumentation
R. Nakamura, M. Hino, H. Tanaka, Y. Kuriyama, Y. Iwashita
Summary: This article introduces a new target station based on a 30-MeV proton accelerator, designed to generate a thermal neutron field for basic study of boron neutron capture therapy (BNCT). The station has high thermal neutron fluxes, characteristics similar to the Kyoto University Research Reactor facility, and realistic shielding size estimation for long-term beam operation.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Biology
Marina Bikchurina, Timofey Bykov, Dmitrii Kasatov, Iaroslav Kolesnikov, Aleksandr Makarov, Ivan Shchudlo, Evgeniia Sokolova, Sergey Taskaev
Summary: A compact neutron source has been proposed and created at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. The source is capable of producing high neutron flux for boron neutron capture therapy (BNCT). BNCT technique has entered clinical practice worldwide, with two clinics in Japan treating patients and four more ready to operate.
Article
Pharmacology & Pharmacy
Alexander Zaboronok, Sergey Taskaev, Olga Volkova, Ludmila Mechetina, Anna Kasatova, Tatiana Sycheva, Kei Nakai, Dmitrii Kasatov, Aleksandr Makarov, Iaroslav Kolesnikov, Ivan Shchudlo, Timofey Bykov, Evgeniia Sokolova, Alexey Koshkarev, Vladimir Kanygin, Aleksandr Kichigin, Bryan J. Mathis, Eiichi Ishikawa, Akira Matsumura
Summary: Boron neutron capture therapy (BNCT) is an anticancer modality that works by accumulating B-10 in tumor cells, irradiating them with neutrons, and damaging tumor cell DNA with the release of alpha-particles and lithium nuclei. Gold nanoparticles placed inside tumor cells saturated with boron were used to accurately measure the absorbed dose, without affecting the efficiency of BNCT.
Article
Chemistry, Multidisciplinary
Takahiro Nomoto, Ying Yao, Yukiya Inoue, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
Summary: In this study, a boron delivery system PEG-P[Lys/Lys(fructose)]-BPA was developed for selective accumulation within the tumor and quick clearance from normal organs and blood. The system showed efficient tumor accumulation and retention in tumor cells, with high accumulation contrast between the tumor and normal tissues. Upon thermal neutron irradiation, PEG-P[Lys/Lys(fructose)]-BPA significantly inhibited tumor growth in mice, suggesting its potential as a promising boron delivery system for BNCT.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biology
Yu Sanada, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga
Summary: The study revealed that hypoxia may reduce the effectiveness of boron neutron capture therapy (BNCT) with BPA in murine squamous cell carcinoma cells, while disruption of Hif-1 alpha increased sensitivity to BNCT.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Chemistry, Physical
Milan Stefanik, Eva Simeckova, Pavel Bem, Jan Stursa, Vaclav Zach, Jaromir Mrazek
Summary: A new neutron field based on a compact accelerator-driven fast neutron source was studied and developed, generating neutrons through ion bombardment of a beryllium layer. The neutron energy spectra were determined for different source-to-sample distances, showcasing the potential for various applications such as neutron activation analysis and radiation hardness tests.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Biology
Shin-ichiro Masunaga, Hitoshi Tatebe, Yasumasa Nishimura, Keizo Tano, Yu Sanada, Takahiro Moriwaki, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Natsuko Kondo, Akira Maruhashi, Koji Ono
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2016)
Article
Oncology
Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa, Shin-Ichi Miyatake
RADIATION ONCOLOGY
(2017)
Article
Instruments & Instrumentation
H. Tanaka, Y. Sakurai, T. Takata, T. Watanabe, S. Kawabata, M. Suzuki, S. -I. Masunaga, K. Taki, K. Akabori, K. Watanabe, K. Ono
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Clinical Neurology
Koji Takeuchi, Shinji Kawabata, Ryo Hiramatsu, Yoko Matsushita, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Koji Ono, Shin-Ichi Miyatake, Toshihiko Kuroiwa
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2018)
Article
Nuclear Science & Technology
Ryosuke Kurihara, Akihiro Nohtomi, Genichiro Wakabayashi, Yoshinori Sakurai, Hiroki Tanaka
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY
(2019)
Article
Biology
Shin-ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Yu Sanada, Keizo Tano, Akira Maruhashi, Koji Ono
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Biology
Koji Ono, Hiroki Tanaka, Yuki Tamari, Tsubasa Watanabe, Minoru Suzuki, Shin-ichiro Masunaga
JOURNAL OF RADIATION RESEARCH
(2019)
Article
Physics, Fluids & Plasmas
Atsushi Sunahara, Takashi Asahina, Hideo Nagatomo, Ryohei Hanayama, Kunioki Mima, Hiroki Tanaka, Yoshiaki Kato, Sadao Nakai
PLASMA PHYSICS AND CONTROLLED FUSION
(2019)
Article
Biology
Takuya Kanemitsu, Shinji Kawabata, Masao Fukumura, Gen Futamura, Ryo Hiramatsu, Naosuke Nonoguchi, Fumiko Nakagawa, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Shin-Ichiro Masunaga, Koji Ono, Shin-Ichi Miyatake, Hiroyuki Nakamura, Toshihiko Kuroiwa
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2019)
Article
Instruments & Instrumentation
H. Tanaka, T. Takata, Y. Ishi, T. Uesugi, Y. Kuriyama, T. Watanabe, Y. Sakurai, S. Kawabata, S- Masunag, M. Suzuki
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2019)
Article
Biology
Shin-ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Yu Sanada, Keizo Tano, Akira Maruhashi, Koji Ono
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Chemistry, Inorganic & Nuclear
Takahiro Kato, Katsumi Hirose, Hiroki Tanaka, Toshinori Mitsumoto, Tomoaki Motoyanagi, Kazuhiro Arai, Takaomi Harada, Akihiko Takeuchi, Ryohei Kato, Satoru Yajima, Yoshihiro Takai
APPLIED RADIATION AND ISOTOPES
(2020)
Article
Chemistry, Multidisciplinary
Changyuan Qin, Xuan Hou, Thahomina Khan, Nobuhiro Nitta, Masashi Yanagawa, Yuriko Sakurai, Minoru Suzuki, Shin-Ichiro Masunaga, Hiroki Tanaka, Yoshinori Sakurai, Hiroyuki Takahashi, Ichio Aoki, Hironobu Yanagie, Horacio Cabral
Article
Radiology, Nuclear Medicine & Medical Imaging
Hironobu Yanagie, Novriana Dewi, Syushi Higashi, Ichiro Ikushima, Koji Seguchi, Ryoji Mizumachi, Yuji Murata, Yasuyuki Morishita, Atsuko Shinohara, Shoji Mikado, Nakahiro Yasuda, Mitsuteru Fujihara, Yuriko Sakurai, Kikue Mouri, Masashi Yanagawa, Tomoya Iizuka, Minoru Suzuki, Yoshinori Sakurai, Shin-Ichiro Masunaga, Hiroki Tanaka, Takehisa Matsukawa, Kazuhito Yokoyama, Takashi Fujino, Koichi Ogura, Yasumasa Nonaka, Hirotaka Sugiyama, Tetsuya Kajiyama, Sho Yui, Ryohei Nishimura, Koji Ono, Sinichi Takamoto, Jun Nakajima, Minoru Ono, Masazumi Eriguchi, Kenichiro Hasumi, Hiroyuki Takahashi
BRITISH JOURNAL OF RADIOLOGY
(2017)
Article
Chemistry, Inorganic & Nuclear
Kenichi Tanaka, Yoshinori Sakurai, Shin-ichiro Hayashi, Tsuyoshi Kajimoto, Ryohei Uchida, Hiroki Tanaka, Takushi Takata, Gerard Bengua, Satoru Endo
APPLIED RADIATION AND ISOTOPES
(2017)
Article
Instruments & Instrumentation
Taisei Hayashi, Kensei Ichiba, Daisuke Nakauchi, Takumi Kato, Noriaki Kawaguchi, Takayuki Yanagida
Summary: In this study, Cr-doped Mg4Ta2O9 single crystals with different doping levels were synthesized using the floating zone method, and their photoluminescence and scintillation properties were evaluated. The results showed that Cr-doped Mg4Ta2O9 single crystals exhibited broad emission bands in the near-infrared region and showed scintillation characteristics within specific wavelength ranges. Additionally, the samples with different Cr doping levels demonstrated different lower detection limits based on the dose rate response function.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
Article
Instruments & Instrumentation
S. Marouf, A. C. Chami, Y. Boudouma
Summary: This study develops a Monte Carlo simulation approach to describe proton-induced secondary electron emission in solids. Theoretical modeling based on the Mott's elastic scattering cross-section and Lindhard's dielectric function was used to calculate the double differential cross-section (DDCS) of excited electrons and describe electron transport in the medium. The results for aluminum show the angular and energy distributions of backscattered electrons for incident protons with energy below 25 keV at normal incidence, and the total electron emission yield also agrees well with available measurements.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
Article
Instruments & Instrumentation
Weipeng Yan, Baojun Duan, Zijian Zhu, Yan Song, Guzhou Song, Jiming Ma, Binkang Li, Yucheng Liu
Summary: This article reports on the scintillation performance of Lithium-doped 2D (PEA)2PbBr4 perovskite single crystals synthesized at room temperature. The crystals exhibit fast decay time, high light yield, and high spatial resolution, making them highly promising for medical diagnostic applications.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
Article
Instruments & Instrumentation
S. B. Vishwakarma, S. K. Dubey, R. L. Dubey, I. Sulania, D. Kanjilal
Summary: Investigations have been conducted on the implanted SiO2 thin film after thermal annealing using various analytical techniques. The results revealed the absence of vacancy defects, variations in vibrational modes and the formation of new structures. The photoluminescence intensity of the annealed SiO2 samples was higher, with a decrease in non-radiative defect centers and an increase in radiative Si:SiO2 interface states. Additionally, the presence of silicon nanoclusters formed after annealing resulted in an additional radiative recombination peak. Furthermore, the formation of new SiOx structures was observed after thermal annealing.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
Article
Instruments & Instrumentation
M. Koshimizu, S. Kurashima, A. Kimura, M. Taguchi
Summary: By observing the scintillation time profiles of CeF3 under irradiations of pulsed beams with different LETs, we found that the initial decay was faster for higher LET, which is consistent with previous studies on other self-activated scintillators. This faster decay at higher LET can be explained by the competition between the scintillation caused by 5d-4f transition of Ce3+ ions and quenching due to the interaction between excited Ce3+ ions close to each other.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
Article
Instruments & Instrumentation
Junjie Shi, Jianhong Hao, Fang Zhang, Qiang Zhao, Bixi Xue, Jieqing Fan, Zhiwei Dong
Summary: This study examined the neutralization process and beam quality of a hydrogen beam by emitting negative hydrogen ions to a hydrogen target. The findings showed that the neutralization efficiency was influenced by variables such as the transport distance, energy, and target gas density. However, the maximal neutralization efficiency was not affected by the density of the target gas or the energy of the negative hydrogen ions.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2024)
