Review
Biochemistry & Molecular Biology
Kheerthana Duraivelan, Dibyendu Samanta
Summary: This review provides a detailed account of the roles of nectin family members in various tumors, highlighting the seemingly opposing roles of some members in tumor-associated pathways where they function as both tumor suppressors and oncogenes. Understanding the functional duality of nectin family in tumors can advance our knowledge of molecular mechanisms regulating tumor development and progression, leading to improved tumor diagnosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Oncology
Pengbo Wang, Zengkuan Zhu
Summary: Expression of E-cadherin is closely associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting it may serve as an effective biomarker for clinical assessments and predicting prognosis in patients with pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Li, Wang Jiang, Shi-Rong Zhang, Peng-Cheng Li, Tian-Jiao Li, Wei Jin, Hua-Xiang Xu, Xian-Jun Yu, Liang Liu
Summary: This study found that CD41+/CD62P+ platelets are closely associated with the prognosis of pancreatic ductal adenocarcinoma (PDAC). High levels of CD41+/CD62P+ platelets were correlated with microvascular invasion, advanced AJCC stage, and high CA19-9 level, and independently predicted a poor prognosis for resectable PDAC. Mechanistically, Panx1 in CD41+/CD62P+ platelets promotes PDAC cell invasion and metastasis by enhancing IL-1 beta secretion through the phosphorylation of p38 MAPK. In addition, a novel compound named PC63435 was synthesized, which blocked the Panx1/IL-1 beta pathway and reduced the proportion of CD41+/CD62P+ platelets, leading to the suppression of PDAC tumor invasion and metastasis.
Article
Cell Biology
Francesca Bianchi, Michele Sommariva, Laura Brigida Cornaghi, Luca Denti, Ambra Nava, Francesca Arnaboldi, Claudia Moscheni, Nicoletta Gagliano
Summary: This study aimed to investigate the relationship between YAP and mechanical cues in pancreatic ductal adenocarcinoma (PDAC) cell lines. It was found that the YAP/p-YAP ratio decreased in PDAC cell lines cultured in a 3D environment, and the expression of CTGF and CYR61 genes was down-regulated. However, inhibition of actin cytoskeleton did not have a significant effect on CTGF and CYR61 expression.
Review
Biochemistry & Molecular Biology
Qianjiang Hu, Komal Saleem, Jyotsana Pandey, Arzoo N. N. Charania, Yong Zhou, Chao He
Summary: The mechanisms of tissue fibrosis pathogenesis are not completely understood. Cell adhesion molecules (CAMs) play critical roles in fibrotic progression in various organs. Dysregulated expression and function of CAMs can lead to chronic inflammation and tissue fibrosis. The major families of CAMs include integrins, cadherins, selectins, and immunoglobulins. In this review, we focus on the role of CAMs, particularly integrins and cadherins, in the development of pulmonary fibrosis.
Review
Oncology
Briana E. Heinly, Christa N. Grant
Summary: Neuroblastoma is a biologically heterogeneous tumor derived from neural crest cells, and its treatment remains challenging. The expression of cell adhesion molecules in neuroblastoma is closely associated with clinical prognosis, and targeted therapies against cell adhesion molecules may represent an innovative treatment strategy in the future.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Supriya Bajpai, Raghunath Chelakkot, Ranganathan Prabhakar, Mandar M. Inamdar
Summary: Cell mechanics and motility, along with contact-dependent cell-cell signalling, are responsible for the collective movement and spatial organization of signalling molecules in epithelial tissues. The coupling between chemical signalling and cell mechanics leads to diverse mechanochemical patterns, with potential applications in understanding cancer and sensory tissues.
Article
Multidisciplinary Sciences
Debanjan Barua, Martina Nagel, Rudolf Winklbauer
Summary: This study comprehensively analyzes cell-cell contacts in multilayered tissues of the Xenopus gastrula model, identifying varying roles of different factors in intercellular contacts, with Syndecan-4 playing a dominant role. By systematically examining the contributions of adhesion factors to intercellular contacts, the study sheds light on the complexity of cell-cell interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jay Rollins, Tyler Worthington, Allison Dransfield, Jordan Whitney, Jordan Stanford, Emily Hooke, Joseph Hobson, Jacob Wengler, Sandra Hope, Dario Mizrachi
Summary: Cell-adhesion molecules (CAMs) are responsible for various cell interactions. In this study, the expression of CLDN proteins in E. coli is investigated and its consequences are discussed. The iCLASP method is introduced as a high-throughput screening approach for identifying paracellular modulators for CLDN2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhi-gang Chen, Yun Wang, William Pat Fong, Ming-tao Hu, Jie-ying Liang, Lingyun Wang, Yu-hong Li
Summary: Utilizing a computational algorithm to estimate immune cell infiltration patterns, two ICI phenotypes were identified in PDAC patients, and an ICIscore was constructed to predict prognosis and chemotherapy benefit. The high ICIscore subtype was associated with immune-active signaling pathways and anti-tumor immunity, while the low ICIscore subtype was linked to tumor progressive signaling pathways. The ICIscore may serve as a prognostic biomarker for patients receiving immune checkpoint inhibitors in various cancer types, highlighting the relationship between the ICI environment and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Hui Zhou, Xiao-xue Li, Yun-peng Huang, Yong-xiang Wang, Heng Zou, Li Xiong, Zhong-tao Liu, Yu Wen, Zi-jian Zhang
Summary: This study compared the clinical features, treatment, and prognosis of PSRCC and PDAC, and established predictive models. The results showed that PSRCC patients were more likely to be male, aged between 58-72 years, have larger tumor masses, and less likely to undergo chemotherapy. After propensity score matching, there was no difference in the prognosis of the two groups. LNR, LODDS, tumor size, age, T-stage, marital status, and summary stage were found to be independent prognostic factors for PSRCC. Prediction models and nomograms based on these factors accurately predicted survival outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Marina Roy-Luzarraga, Louise E. Reynolds, Beatriz de Luxan-Delgado, Oscar Maiques, Laura Wisniewski, Emma Newport, Vinothini Rajeeve, Rebecca J. G. Drake, Jesus Gomez-Escudero, Frances M. Richards, Celine Weller, Christof Dormann, Ya-Ming Meng, Peter B. Vermeulen, Dieter Saur, Victoria Sanz-Moreno, Ping-Pui Wong, Cyrill Geraud, Pedro R. Cutillas, Kairbaan Hodivala-Dilke
Summary: This study reveals that endothelial cell focal adhesion kinase (FAK) plays a role in regulating pancreatic ductal adenocarcinoma (PDAC) metastasis and impacting the outcome of gemcitabine treatment. The findings suggest the potential clinical utility of combinatorial endothelial cell FAK targeting with gemcitabine in controlling metastasis in PDAC patients.
Article
Multidisciplinary Sciences
Bin Xie, Allison Maker, Andrew Priest, David M. Dranow, Jenny N. Phan, Thomas E. Edwards, Bart L. Staker, Peter J. Myler, Barry M. Gumbiner, Sanjeevi Sivasankar
Summary: The monoclonal antibody 19A11 can interact with Ecad in two distinct modes, one of which enhances the adhesion of Ecad. Adhesion is strengthened by the formation of a salt bridge.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Wenbin Kuang, Xiao Wang, Jiayu Ding, Jiaxing Li, Minghui Ji, Weijiao Chen, Liping Wang, Peng Yang
Summary: This study conducted a comprehensive analysis of the members of the PTPN family and emphasized the key role of PTPN2 as a potential therapeutic target and diagnostic biomarker in improving the survival rate of PAAD. The results showed that up-regulation of PTPN2 expression was associated with poor prognosis in PAAD and silencing of PTPN2 inhibited PAAD cell growth, migration, invasion, and induced cell cycle arrest and apoptosis. Furthermore, key factors and target genes related to PTPN2 were identified.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li, Sheng Yan
Summary: The study showed that high vimentin expression with loss of E-cadherin expression in patients with grade 1 and 2 pNETs undergoing resection was correlated with risks of lymph node metastasis, distant metastasis, disease progression, and poor prognosis.
Article
Medicine, General & Internal
Mari Takahashi, Yukihiro Horio, Takahisa Takihara, Keito Enokida, Masashi Miyaoka, Kenichi Hirabayashi, Kana Ohshinden, Shigeaki Hattori, Fuminari Takahashi, Genki Takahashi, Jun Tanaka, Hiroto Takiguchi, Kyoko Niimi, Yoko Ito, Naoki Hayama, Tsuyoshi Oguma, Koichiro Asano
Summary: A 72-year-old man with idiopathic pulmonary fibrosis was diagnosed with lung squamous cell carcinoma in the right lung. The tumor responded positively to the discontinuation of immunosuppressants and remained regressed for 9 months without receiving anti-cancer treatments. This case suggests a potential new approach for non-hematologic solid organ tumors.
Review
Oncology
Akira Nakano, Kenichi Hirabayashi, Hiroshi Yamamuro, Taro Mashiko, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa, Toshio Nakagohri
Summary: The study presented a rare case of combined-type HCC-NEC tumor that was successfully treated surgically. Multidisciplinary collaboration is crucial for the accurate diagnosis of this disease, and further accumulation of cases is needed to understand its exact pathology, diagnosis, and treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoshiki Naito, Masayuki Tsuneki, Noriyoshi Fukushima, Yutaka Koga, Michiyo Higashi, Kenji Notohara, Shinichi Aishima, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Yuki Fukumura, Motohiro Kojima, Kenichi Hirabayashi, Yoshihiro Hamada, Tomoko Norose, Keita Kai, Yuko Omori, Aoi Sukeda, Hirotsugu Noguchi, Kaori Uchino, Junya Itakura, Yoshinobu Okabe, Yuichi Yamada, Jun Akiba, Fahdi Kanavati, Yoshinao Oda, Toru Furukawa, Hirohisa Yano
Summary: In this study, a deep learning model was trained to assess PDAC on EUS-FNB specimens of the pancreas in histopathological whole-slide images with high accuracy. The model was able to accurately detect isolated and low volume cancer cells, showing potential as a supportive system in routine diagnosis of pancreatic EUS-FNB specimens.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Masanao Yokohira, Minoru Oshima, Keiko Yamakawa, Juanjuan Ye, Yuko Nakano-Narusawa, Reiji Haba, Yuki Fukumura, Kenichi Hirabayashi, Hiroshi Yamaguchi, Motohiro Kojima, Keiichi Okano, Yasuyuki Suzuki, Yoko Matsuda
Summary: Standardized pathological evaluation is needed for the regression assessment of neoadjuvant pancreatic cancer to improve prognosis and compare treatment outcomes. Discrepancies were found between the largest cancer slides determined macroscopically and histologically, suggesting that obtaining the largest histological slides is necessary for adequate assessment in neoadjuvant-treated pancreatic cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ryuji Komine, Motohiro Kojima, Genichiro Ishi, Masashi Kudo, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Tatsushi Kobayashi, Tetsuo Akimoto, Ayumi Murakami, Motoko Sasaki, Mariko Tanaka, Akiko Matsuzaki, Nobuyuki Ohike, Katsunori Uchida, Tomoko Sugiyama, Kenichi Hirabayashi, Takuma Tajiri, Kazuyuki Ishida, Keita Kai, Yuko Omori, Kenji Notohara, Hiroshi Yamaguchi, Yoko Matsuda, Yoshiki Naito, Yuki Fukumura, Yoshihiro Hamada, Yumi Mihara, Yohei Masugi, Naoto Gotohda, Kenichi Harada, Noriyoshi Fukushima, Toru Furukawa
Summary: Determining the primary tumor in periampullary region carcinomas presents challenges, with many cases mistakenly diagnosed as pancreatic cancer. This study found that a portion of cases had tumors with an indeterminable origin. Histological studies showed these tumors spreading along both the bile duct and main pancreatic duct, indicating their unique characteristics.
Article
Pathology
Kenji Notohara, Terumi Kamisawa, Toru Furukawa, Noriyoshi Fukushima, Takeshi Uehara, Satomi Kasashima, Eisuke Iwasaki, Atsushi Kanno, Atsuhiro Kawashima, Kensuke Kubota, Yasuhiro Kuraishi, Masayo Motoya, Itaru Naitoh, Takayoshi Nishino, Junichi Sakagami, Kyoko Shimizu, Teruko Tomono, Shinichi Aishima, Yuki Fukumura, Kenichi Hirabayashi, Motohiro Kojima, Tomoko Mitsuhashi, Yoshiki Naito, Nobuyuki Ohike, Takuma Tajiri, Hiroshi Yamaguchi, Hideyo Fujiwara, Emi Ibuki, Shota Kobayashi, Masashi Miyaoka, Mamiko Nagase, Junko Nakashima, Masamichi Nakayama, Shinsuke Oda, Daiki Taniyama, Sho Tsuyama, Syunsuke Watanabe, Tsukasa Ikeura, Shigeyuki Kawa, Kazuichi Okazaki
Summary: Histological diagnosis of type 1 autoimmune pancreatitis (AIP) using endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) is feasible, but diagnostic consistency is not confirmed. Guidance is effective for improving accurate PDAC diagnoses and evaluating storiform fibrosis.
Article
Oncology
Reiko Doi, Yuki Fukumura, Rong Lu, Kenichi Hirabayashi, Yuko Kinowaki, Yasuni Nakanuma, Yoshiakira Kanai, Jun Nakahodo, Noriko Sasahara, Tsuyoshi Saito, Takashi Yao
Summary: This study identified differences between type 1 and type 2 intraductal papillary neoplasms of the bile duct (IPNB) using multiple gene expression analysis and immunohistochemistry. Type 2 IPNB showed increased expression of DNMT1 protein and DNA methylation frequency compared to type 1. DNMT1 IHC may be useful in distinguishing between these two types.
ANTICANCER RESEARCH
(2022)
Article
Pathology
Yifare Maimaitiaili, Yuki Fukumura, Kenichi Hirabayashi, Yuko Kinowaki, Yoshiki Naito, Akira Saito, Lu Rong, Jun Nakahodo, Takashi Yao
Summary: The study confirmed the sensitivity and specificity of fusion genes in relation to IOPNs, and investigated their role in combined IOPNs and the potential development of IOPNs through IPMNs/IPNBs.
Article
Multidisciplinary Sciences
Kenichi Hirabayashi, Masaki Miyazawa, Yumi Takanashi, Masashi Morimachi, Aya Kawanishi, Tsubasa Saika, Toshio Nakagohri, Naoya Nakamura
Summary: miR-4653-3p is associated with invasiveness, tumorigenesis, and prognosis of PDAC. High expression of miR-4653-3p is correlated with advanced clinical and pathological features and worse prognosis. HIPK2 has been identified as a target of miR-4653-3p, and miR-4653-3p participates in PDAC development and worse prognosis by reducing HIPK2 expression.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka, Christopher Wittwer, Kenta Kikuchi, Takatoshi Iijima, Yu Kakimoto, Kenichi Hirabayashi, Daisuke Kurotaki, Henning J. Jessen, Adolfo Saiardi, Eiichiro Nagata
Summary: Inositol pyrophosphates are highly active in regulating physiological processes, with the gastrointestinal tract showing the highest levels. The IP6K2-IP7 axis plays a critical role in the developmental and functional regulation of the enteric nervous system.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Surgery
Taro Mashiko, Toshihito Ogasawara, Yoshihito Masuoka, Shigenori Ei, Shinichiro Takahashi, Kenichi Hirabayashi, Masaki Mori, Kazuo Koyanagi, Seiichiro Yamamoto, Toshio Nakagohri
Summary: Positive peritoneal lavage cytology has a poor prognostic impact on resectable pancreatic body and tail cancer patients and is associated with clinicopathological factors and recurrence.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Toshio Nakagohri, Shinichiro Takahashi, Shigenori Ei, Yoshihito Masuoka, Taro Mashiko, Toshihito Ogasawara, Kenichi Hirabayashi
Summary: Positive surgical margin and nodal involvement are the strongest predictors of poor survival in patients with distal cholangiocarcinoma. Patients with a positive radial margin have a significantly worse outcome than those with a positive ductal margin.
WORLD JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Yoshiki Naito, Kenji Notohara, Yuko Omori, Shinichi Aishima, Takao Itoi, Nobuyuki Ohike, Yoshinobu Okabe, Motohiro Kojima, Takuma Tajiri, Mariko Tanaka, Masayuki Tsuneki, Toshio Nakagohri, Tomoko Norose, Kenichi Hirabayashi, Yuki Fukumura, Tomoko Mitsuhashi, Hiroshi Yamaguchi, Noriyoshi Fukushima, Toru Furukawa
Summary: This study aimed to establish a reliable and reproducible categorized diagnostic classification system with identification of key features to achieve accurate pathological diagnosis of endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) samples of pancreatic lesions.
Review
Gastroenterology & Hepatology
Kenichi Hirabayashi, Tsubasa Saika, Naoya Nakamura
Summary: Cytology is a useful method for diagnosing pancreatic neoplasms, and the evaluation of both tumor cells and background features is important for accurate diagnosis. Different histological types of pancreatic neoplasms have their own characteristic background features, highlighting the need for comprehensive analysis.
Meeting Abstract
Gastroenterology & Hepatology
Nana Mamuro, Yoshihito Masuoka, Taro Mashiko, Akira Nakano, Kenichi Hirabayashi, Toshio Nakagohri
