Article
Biochemistry & Molecular Biology
Andrea Ferrigno, Marta Cagna, Oriana Bosco, Michelangelo Trucchi, Clarissa Berardo, Ferdinando Nicoletti, Mariapia Vairetti, Laura G. Di Pasqua
Summary: In this study, the effects of mGluR5 blockade were evaluated in a mouse model of steatosis. It was found that MPEP can reduce fat accumulation and oxidative stress. This study provides the first in vivo evidence of the beneficial effects of MPEP in a murine model of steatosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Francesco Campa, Tindaro Bongiovanni, Alessio Rossi, Giuseppe Cerullo, Andrea Casolo, Giulia Martera, Athos Trecroci, Tatiana Moro, Antonio Paoli
Summary: New predictive models were developed to estimate fat-free mass (FFM) components in male elite soccer players, showing higher accuracy than existing generalized formulas. The newly developed soccer-specific formulas enable valid estimations of body composition, avoiding underestimation issues seen with generalized equations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Georgios-Ioannis Verras, Francesk Mulita, Sjaak Pouwels, Chetan Parmar, Nikolas Drakos, Konstantinos Bouchagier, Charalampos Kaplanis, George Skroubis
Summary: Morbid obesity is a chronic disease with a rising incidence, and surgical treatment has shown superior outcomes compared to conventional weight loss measures. This study evaluated the long-term weight loss outcomes, comorbidity reduction, and adverse effects of Roux-en-Y Gastric Bypass (RYGB), Biliopancreatic Diversion (BPD), and Sleeve Gastrectomy (SG) at 10 years. RYGB and BPD resulted in significant weight loss, with no observed differences in diabetes resolution and adverse outcomes. Longer follow-up reports are important for comparing the outcomes of different bariatric operations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaojing Wei, Chuanfei Wei, Yutian Tan, Ximing Dong, Zhao Yang, Jianqun Yan, Xiao Luo
Summary: This study aimed to determine the regulation of NAD+-related enzymes in the liver and their relationships with glucose and lipid metabolism. It was found that both high-fat diet feeding and calorie restriction increased hepatic NAD+ levels and the expression of related genes. In addition, high-fat diet feeding and calorie restriction had different effects on hepatic lipogenesis and gluconeogenesis. These findings highlight the importance of hepatic NAD+ metabolism in maintaining metabolic flexibility.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Silvia Ferro, Viola Zulian, Massimiliano De Palma, Andrea Sartori, Anamaria Andreica, Marius Nedelcu, Sergio Carandina
Summary: This study retrospectively reviewed patients who underwent laparoscopic resizing of the gastric pouch (LPR) after weight regain (WR) following gastric bypass procedures. The results showed that LPR had good outcomes in terms of weight loss and improvement of comorbidities, with an acceptable rate of complications and operative time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Jan O. Aaseth, Helge Rootwelt, Kjetil Retterstol, Knut Hestad, Per G. Farup
Summary: This study compared the efficacy of two commonly used bariatric procedures and found that gastric bypass was more effective in mitigating dyslipidemia caused by obesity.
Article
Surgery
B. K. Wolnerhanssen, R. Peterli, S. Hurme, M. Bueter, M. Helmio, A. Juuti, A. C. Meyer-Gerspach, M. Slawik, P. Peromaa-Haavisto, P. Nuutila, P. Salminen
Summary: After 5 years of follow-up, it was found that LRYGB resulted in greater weight loss and better improvement in hypertension compared to LSG, but there was no significant difference in remission of T2DM, obstructive sleep apnoea, or quality of life. The complication rate was higher after LRYGB, but the individual burden for patients with complications was similar after both operations.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Nutrition & Dietetics
Emanuele Cereda, Paolo Pedrazzoli, Federica Lobascio, Sara Masi, Silvia Crotti, Catherine Klersy, Annalisa Turri, Nicole Stobaus, Maja Tank, Kristina Franz, Sara Cutti, Ester Giaquinto, Andrea Riccardo Filippi, Kristina Norman, Riccardo Caccialanza
Summary: This study investigated the impact of reduced muscle mass on the prognosis of cancer patients and found that decreased FFMI independently predicted survival and was associated with impaired quality of life.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Qian Liu, Jie Fang, Wenqi Huang, Sining Liu, Xueting Zhang, Guiping Gong, Linjuan Huang, Xiaoliang Lin, Zhongfu Wang
Summary: This study investigated the effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-induced obese mice. The results showed that konjac glucomannan with higher molecular weight reduced body weight and improved insulin resistance. It also inhibited lipid accumulation in the liver by regulating gene expression. Furthermore, konjac glucomannan at different molecular weights caused changes in gut microbial diversity. These findings provide a scientific basis for the development and utilization of konjac resources.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Dag Hofso, Thor Olav Wideroe Hillestad, Erling Halvorsen, Farhat Fatima, Line Kristin Johnson, Morten Lindberg, Marius Svanevik, Rune Sandbu, Joran Hjelmesaeth
Summary: Results of the study showed that bone mineral density decreased significantly more after RYGB compared to SG at the femoral neck, total hip, and lumbar spine. Additionally, markers of bone turnover were approximately 100% higher after RYGB than after SG. These changes were independently associated with the surgical procedure and not weight change.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Physiology
Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton
Summary: This study on zebrafish shows that a high-calorie diet, regardless of fat content, can lead to kidney pathology, but these changes can be reversed after 4 weeks of calorie restriction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michiel Bronswijk, Giuseppe Vanella, Hannah Van Malenstein, Wim Laleman, Joris Jaekers, Baki Topal, Freek Daams, Marc G. Besselink, Paolo Giorgio Arcidiacono, Rogier P. Voermans, Paul Fockens, Alberto Larghi, Roy L. J. van Wanrooij, Schalk W. Van der Merwe
Summary: This study compared the efficacy of EUS-guided gastroenterostomy (EUS-GE) and laparoscopic gastroenterostomy (L-GE) in gastric outlet obstruction management, finding similar technical and clinical success rates between the two. However, EUS-GE showed shorter time to oral intake, shorter hospital stay, and lower rate of severe adverse events compared to L-GE.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Mehran Sohrabi Maralani, Sina Azadnajafabad, Fezzeh Elyasinia, Maryam Abolhasani, Mohammadjavad Bagheri, Farhad Kor, Amir Ashrafi, Mohammad Talebpour
Summary: This study evaluated the outcomes of hand-sewn OAGB and found it to be an efficient and safe technique in managing patients undergoing OAGB surgery, with acceptable results and rare adverse complications. Over a 5-year follow-up, patients experienced weight loss and improvements in BMI, with an increase in excess weight loss rate.
Article
Surgery
Jeremy Jen, Hau Phan, Brett Johnson, Corliann Blyn, Janet Lavrich, Krishna Mallem, Priya Kalsank Pai, Piotr Krecioch
Summary: Revisional surgery to convert sleeve gastrectomy (SG) to either Roux-en-Y gastric bypass (RYGB) or duodenal switch (DS) can lead to significant and sustained weight loss in the first 12 months. There was no significant difference in excess body weight loss between RYGB and DS patients at 6, 12, and 24 months, except for greater weight loss in RYGB patients at 3 months. Procedure length was significantly longer for DS compared to RYGB, with no significant differences in length of stay and 30-day readmission rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
David Sien Chin Soon, Xavier Moar, Dewei Jordan Lee, Patrick Moore, Anthony Clough
Summary: This study reported the first high-volume experience of robotic-assisted Roux-en-Y gastric bypass surgery in Australia and compared outcomes with a similar laparoscopic group. The robotic group had longer operating times but lower complication rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Microbiology
Jorik M. van Rijn, Jens Eriksson, Jana Gruttner, Magnus Sundbom, Dominic-Luc Webb, Per M. Hellstrom, Staffan G. Svard, Mikael E. Sellin
Summary: Understanding the dynamic interactions between individual microbes and host cells is crucial for infectious disease research. A new method for live-cell imaging of microbial infection dynamics on human intestinal epithelial cell layers has been developed, providing insights into the behavior of Salmonella and Giardia pathogens.
Article
Surgery
Martin L. Skogar, Erik Stenberg, Magnus Sundbom
Summary: The aim of this study was to explore whether the weekday of surgery affects the 30-day complication risks after primary Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The study found that there was no significant increased risk of overall complications, severe complications, or readmission rates by weekday of surgery, except for a lower readmission rate in patients operated on Tuesdays.
Article
Surgery
Martin L. Skogar, Magnus Sundbom
Summary: This study investigated the association between NSAID exposure and peptic ulcers after laparoscopic RYGB and SG surgeries. The results showed that long-term NSAID use (>=30 days) after RYGB was a significant risk factor for the development of peptic ulcers, while no association was found between NSAID exposure and peptic ulcers after SG.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Surgery
Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Naslund
Summary: This study aimed to assess the short-term and long-term outcomes of metabolic and bariatric surgery in patients with attention deficit hyperactivity disorder (ADHD). The results showed that patients with ADHD treated pharmacologically for ADHD experienced similar weight loss and remission of obesity-related diseases compared to patients without ADHD. However, they reported a lower health-related quality of life and had an increased risk of substance abuse and self-harm.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Anna Laurenius, Magnus Sundbom, Johan Ottosson, Erik Näslund, Erik Stenberg
Summary: Obesity is associated with an increased risk of kidney stones, especially after metabolic and bariatric surgery. However, there is a lack of reports on baseline risk factors and larger population-based cohorts. This study aimed to evaluate the incidence and risk factors for postoperative kidney stones after bariatric surgery by comparing them to a matched control group from the normal population.
Article
Surgery
Magnus Sundbom, Eladio Cabrera, Rickard Nyman, Charlotte Ebeling Barbier, Ulf Johnson, Mikael Ljungdahl
Summary: This study compared percutaneous endoscopic gastrostomy (PEG) with radiologically inserted gastrostomy (RIG) in adults and found that PEG had shorter operative time, lower rate of adverse events, and lower 30-day mortality, making it the recommended primary procedure. However, RIG is also a valid alternative method.
SCANDINAVIAN JOURNAL OF SURGERY
(2023)
Article
Microbiology
Jana Gruttner, Jorik M. van Rijn, Petra Geiser, Alexandra Florbrant, Dominic-Luc Webb, Per M. Hellstrom, Magnus Sundbom, Mikael E. Sellin, Staffan G. Svard
Summary: Giardia intestinalis is a parasite that infects the upper small intestine of mammals. It can cause diarrhoeal disease in humans, but many infections do not cause symptoms. The molecular mechanisms behind these different outcomes are still unclear.
Article
Surgery
Filip Moller, Jakob Hedberg, Martin Skogar, Magnus Sundbom
Summary: In super obesity, biliopancreatic diversion with duodenal switch (BPD/DS) is advocated by some surgeons as a more effective procedure compared to Roux-en-Y gastric bypass (RYGB). However, there is limited evidence on long-term outcomes beyond 10 years. This study compared the long-term outcome of BPD/DS and RYGB in patients with super obesity and found that BPD/DS resulted in superior weight loss, metabolic control, and BAROS score, but with more adverse events.
Editorial Material
Respiratory System
Magnus Sundbom
JOURNAL OF THORACIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Eva Randell, Petros Katsogiannos, Janeth Leksell, Jan W. W. Eriksson, Magnus Sundbom, Maria Svedbo Engstrom
Summary: This qualitative study examined how adults with previous type 2 diabetes perceived different sources of support two years after bariatric surgery. The findings revealed that support needs changed over time and that long-term professional and day-to-day support from family and other networks were essential and complementary.
Article
Endocrinology & Metabolism
Giovanni Fanni, Christakis Kagios, Erika Roman, Magnus Sundbom, Johan Wikstrom, Sven Haller, Jan W. Eriksson
Summary: This study aimed to investigate the effect of Roux-en-Y gastric bypass (RYGB) on brain connectivity, and found that RYGB can alter the connectivity of neural pathways related to reward, inhibitory control, and energy homeostasis. These changes are associated with alterations in hypoglycemic responses and may contribute to the glucose metabolic outcomes of RYGB.
Review
Endocrinology & Metabolism
Magnus Sundbom, Ingmar Naslund, Johan Ottosson, Erik Stenberg, Erik Naslund
Summary: The Scandinavian Obesity Surgery Registry (SOReg) is a high-quality database used to monitor the results of bariatric surgery and conduct research. Swedish bariatric surgery has low mortality rates compared to other countries, and gastric bypass surgery significantly improves obesity-related diseases and quality of life while reducing the risk of cardiac failure and major adverse cardiovascular events. Additionally, the database reveals a correlation between low socioeconomic status and reduced opportunities for surgery and inferior outcomes.
Meeting Abstract
Gastroenterology & Hepatology
Lars Johansson, Magnus Sundbom, Edvin Johansson, Joel Kullberg
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Khalid Elias, Dominic-Luc Webb, Hetzel O. Diaz Tartera, Per M. Hellstrom, Magnus Sundbom
Article
Surgery
Johanna Fall, Magnus Sundbom, Erik Stenberg
Summary: This study examines the impact of summer closure on the incidence of serious postoperative complications in bariatric surgery using a large cohort. The results indicate that summer closure increases the risk of serious complications in gastric bypass surgery, while no statistically significant association was found in sleeve gastrectomy surgery or overall complication rate.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
