Review
Plant Sciences
Yingqi Cai, Xiao-Hong Yu, John Shanklin
Summary: Plants convert carbohydrates into energy-dense lipids through photosynthesis, making plant oils an economically and sustainably attractive feedstock for biofuels and value-added bioproducts. Various strategies have been developed to enhance lipid accumulation and produce specialty lipids with increased uses and value. Successful metabolic engineering involves expression of lipogenic factors from other sources or with specialized functionality.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Zahra Shokravi, Hoofar Shokravi, A. E. Atabani, Woei Jye Lau, Ong Hwai Chyuan, Ahmad Fauzi Ismail
Summary: This paper provides a compilation of technical developments aimed at promoting fatty acid profile (FAP) and lipid yield (LY) during the harvesting process of microalgae. Co-cultivating specific microalgae with fungi, bacteria, or other microalgae strains was found to improve flocculation efficiency and FAP&LY. Proper wet storage conditions and stress induction strategies could enhance FAP&LY efficiency and reduce expenses associated with cell drying and related equipment. Enhancing FAP&LY through the harvesting process could be a breakthrough technology for cost-efficient microalgaebased biodiesel production.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Agriculture, Dairy & Animal Science
R. Rodriguez-Sanchez, A. Tres, R. Sala, M. D. Soler, F. Guardiola, A. C. Barroeta
Summary: The study demonstrates that the majority of fatty acids are absorbed in the jejunum regardless of dietary fat source, with higher absorption efficiency in broilers fed with unsaturated diets. Dietary FFA levels can affect the fatty acid absorption process, while including acid oils up to 35% in broiler diets does not have a negative impact on absorption.
Article
Biotechnology & Applied Microbiology
Shekhar Mishra, Ziyu Wang, Michael J. Volk, Huimin Zhao
Summary: This article reports the development of a kinetic metabolic model of lipid metabolism in Saccharomyces cerevisiae, which integrates various aspects of lipid biosynthesis and transport. The model was trained on lipidomic data and used to design mutant strains for overproduction of lipids. The model-guided experiments led to the discovery of a futile cycle in the triacylglycerol biosynthesis pathway and provided explanations for successful and unsuccessful mutant designs in metabolic engineering.
METABOLIC ENGINEERING
(2023)
Review
Plant Sciences
Changcheng Xu, Jilian Fan
Summary: This review discusses the metabolic interplay between autophagy and lipid droplet dynamics, mechanisms of lipophagy, and cellular management of lipotoxic stress during autophagy. Autophagy degrades membrane lipids to provide fatty acids for energy production, while lipid droplets can be degraded via lipophagy in times of energy scarcity. However, lipid droplets are also necessary for efficient autophagic processes, and cells must carefully manage the cytotoxic effects of free fatty acids during autophagy-mediated mobilization for energy generation.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Angela M. Gajda, Hiba R. Tawfeeq, Atreju I. Lackey, Yin Xiu Zhou, Hamzeh Kanaan, Arete Pappas, Heli Xu, Sarala Kodukula, Judith Storch
Summary: This study generated LFABP and IFABP double knockout mice and found that IFABP and LFABP have different functions in intestinal lipid assimilation and their absence leads to alterations in systemic energy metabolism, but the FABPs are not required for net intestinal uptake of dietary lipid.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Fisheries
Jiaxiang Luo, Qicun Zhou, Xiangsheng Zhang, Tingting Zhu, Yingying Zhang, Zheng Yang, Chen Guo, Shichao Xie, Jingjing Lu, Ye Yuan, Lefei Jiao, Min Jin
Summary: The study found that medium levels of dietary zinc were beneficial for growth and fatty acid metabolism of mud crab, while high levels of dietary zinc had adverse effects on lipid content and fatty acid accumulation in the hepatopancreas.
Article
Plant Sciences
Renato Crespo Pereira, Wladimir Costa Paradas, Rodrigo Tomazetto de Carvalho, Davyson de Lima Moreira, Alphonse Kelecom, Raoni Moreira Ferreira Passos, Georgia Correa Atella, Leonardo Tavares Salgado
Summary: The brown marine macroalga Padina gymnospora produces defensive chemicals and calcium carbonate on its surface as potential protections against herbivory. The chemical compounds extracted from P. gymnospora showed a significant reduction in consumption by the sea urchin Lytechinus variegatus, while the calcium carbonate did not provide physical protection. A specific hydrocarbon compound, 5Z,8Z,11Z,14Z-heneicosatetraene, exhibited a significant defensive property against the sea urchin.
Review
Pharmacology & Pharmacy
William George Warren, Myles Osborn, Andy Yates, Karen Wright, Saoirse E. O'Sullivan
Summary: Fatty acid binding protein 5 (FABP5) is an intracellular chaperone that regulates lipid metabolism and cell growth. Increased expression of FABP5 is associated with poor prognosis in tumors, and inhibiting FABP5 reduces protumoral markers, making it a potential therapeutic target. The strongest evidence base currently exists for liver, prostate, breast, brain cancers, and squamous cell carcinoma (SCC).
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Zoe Day, Alyce J. Mayfosh, Marie-Claire Giel, Yuning Hong, Scott A. Williams, Jascinta P. Santavanond, Thomas F. Rau, Ivan K. Poon, Mark D. Hulett
Summary: This study presents a novel platform for solubilizing fatty acids using amino acids and investigates the tumoricidal activity and mechanism of undecylenic acid. The results demonstrate that the GS-1 formulation, a combination of undecylenic acid and L-Arginine, induces concentration-dependent tumor cell death through a pro-apoptotic mechanism. GS-1 localizes to lipid droplets intracellularly and is taken up by cells via Fatty Acid Transport Protein 2 (FATP2). These findings contribute to the emerging field of fatty acids as potential anti-cancer therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Xiufen Zhang, Qilin Wu, Wenxuan Zheng, Chuang Liu, Liang Huang, Xin Zuo, Wenquan Xiao, Xiaofeng Han, Hui Ye, Wence Wang, Lin Yang, Yongwen Zhu
Summary: This study investigated the effects of exogenous fatty acid intervention on embryonic development in an avian embryo model. It was found that hepatic lipid and fatty acid metabolism play critical roles in embryogenesis. The intervention with oleic acid affected lipid metabolism and gene expression related to fatty acid uptake, synthesis, and oxidation in the embryos.
Article
Multidisciplinary Sciences
Wenyue Dong, Xiaoqun Nie, Hong Zhu, Qingyun Liu, Kunxiong Shi, Linlin You, Yu Zhang, Hongyan Fan, Bo Yan, Chen Niu, Liang-Dong Lyu, Guo-Ping Zhao, Chen Yang
Summary: FdmR is identified as a key regulator of fatty acid catabolism in Mycobacterium marinum, controlling the direction of fatty acid breakdown and the supply of long-chain acyl-CoAs to affect cell growth and pathogenicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Chadwick V. Jay, Sara J. Iverson, Anthony S. Fischbach
Summary: The study found that there was no difference in lipid content between the inner and outer blubber layers of walruses, but there were differences in fatty acid composition. The lipid content in the sternum of lactating females was higher than non-lactating females, and there were variations in lipid content and fatty acid composition among study years.
FRONTIERS IN MARINE SCIENCE
(2021)
Review
Veterinary Sciences
Einar Vargas-Bello-Perez, Babak Darabighane, Florencia E. Miccoli, Pilar Gomez-Cortes, Manuel Gonzalez-Ronquillo, Marcello Mele
Summary: Inclusion of dietary vegetable sources rich in UFA in sheep diets helps improve cheese composition by decreasing saturated FA content and increasing polyunsaturated FA content. However, the effects on milk yield, milk fat percentage, and milk protein percentage are not significant, with significant heterogeneity present.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Klaudia Sztolsztener, Ewa Harasim-Symbor, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Summary: The study evaluated the potential protective effects of dexamethasone on hepatocellular lipid metabolism and fatty acid transporters expression. The results showed that combined treatment of dexamethasone and palmitate could exacerbate lipotoxicity in HepG2 cells by altering lipid composition and increasing lipid deposition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)